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D-Index & Metrics

Molecular Biology

D-Index
95
Citations
101435
World Ranking
618
National Ranking
339

Medicine

D-Index
96
Citations
101827
World Ranking
9448
National Ranking
4875

Overview

Lawrence A. Donehower is affiliated with Baylor College of Medicine in the United States. Their research primarily centers on biochemistry, genetics, and molecular biology, with a notable focus on cancer research, molecular biology techniques, genetics, and oncology.

Donehower's publication record spans several specialized subfields including molecular biology, cancer research, genetics, pulmonary and respiratory medicine, and oncology. Their work addresses topics such as cancer genomics and diagnostics, glioma diagnosis and treatment, epigenetics and DNA methylation, sarcoma diagnosis and treatment, virus-based gene therapy research, molecular biology techniques and applications, and evolution and genetic dynamics.

Recent papers authored or co-authored by Donehower include:

  • A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement, 2021, Nature Communications
  • K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications, 2022, Disease Models & Mechanisms
  • WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation, 2020, Cell Cycle
  • A general calculus of fitness landscapes finds genes under selection in cancers, 2022, Genome Research
  • EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants, 2022, Nucleic Acids Research

Frequent co-authors collaborating with Donehower include:

  • Chad J. Creighton
  • Teng-Kuei Hsu
  • Jennifer Asmussen
  • Byung-Kwon Choi
  • Panagiotis Katsonis

Donehower's research has been published across various venues, reflecting a multidisciplinary approach. These venues include:

  • UNC Libraries
  • Nature Communications
  • Disease Models & Mechanisms
  • Genome Research
  • Cell Cycle

Best Publications

  • Comprehensive molecular portraits of human breast tumours

    Daniel C. Koboldt;Robert S. Fulton;Michael D. McLellan;Heather Schmidt

  • The cancer genome atlas pan-cancer analysis project

    John N Weinstein;John N Weinstein;Eric A. Collisson;Gordon B Mills;Kenna R Mills Shaw;Kenna R Mills Shaw

  • Comprehensive molecular characterization of human colon and rectal cancer

    Donna M. Muzny;Matthew N. Bainbridge;Kyle Chang;Huyen H. Dinh

  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways

    Roger McLendon;Allan Friedman;Darrell Bigner;Erwin G. Van Meir

  • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

    Lawrence A. Donehower;Michele Harvey;Betty L. Slagle;Mark J. McArthur

  • The Immune Landscape of Cancer

    Vésteinn Thorsson;David L Gibbs;Scott D Brown;Denise Wolf

  • Comprehensive molecular characterization of urothelial bladder carcinoma

    John N Weinstein;Rehan Akbani;Bradley McIntosh Broom;Wenyi Wang

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas

    Francisco Sanchez-Vega;Marco Mina;Joshua Armenia;Walid K. Chatila

  • Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.

    Katherine A. Hoadley;Christina Yau;Christina Yau;Toshinori Hinoue;Denise M. Wolf

  • Comprehensive Characterization of Cancer Driver Genes and Mutations.

    Matthew H Bailey;Collin Tokheim;Eduard Porta-Pardo;Sohini Sengupta

  • Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

    Adrian Ally;Miruna Balasundaram;Rebecca Carlsen;Eric Chuah

  • Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint

    Qinghua Liu;Saritha Guntuku;Xian Shu Cui;Shuhei Matsuoka

  • p53 mutant mice that display early ageing-associated phenotypes

    Stuart D. Tyner;Sundaresan Venkatachalam;Jene Choi;Stephen Jones

  • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

    Stephen N. Jones;Amy E. Roe;Lawrence A. Donehower;Allan Bradley

  • Genomic and Functional Approaches to Understanding Cancer Aneuploidy

    Alison M. Taylor;Alison M. Taylor;Juliann Shih;Gavin Ha;Gavin Ha;Galen F. Gao

  • Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

    Theo A Knijnenburg;Linghua Wang;Michael T Zimmermann;Nyasha Chambwe

  • The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma

    Caleb F. Davis;Christopher J. Ricketts;Min Wang;Lixing Yang

  • Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.

    Stuart M Chambers;Chad A Shaw;Catherine Gatza;C. Joseph Fisk

  • Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

    Yasushi Totoki;Kenji Tatsuno;Kyle R. Covington;Hiroki Ueda

  • The Cancer Genome Atlas Pan-Cancer analysis project

    Kyle Chang;Chad J Creighton;Caleb Davis;Lawrence Donehower

Frequent Co-Authors

Allan Bradley
Allan Bradley University of Cambridge
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine
David A. Wheeler
David A. Wheeler Baylor College of Medicine
Chad J. Creighton
Chad J. Creighton Baylor College of Medicine
Xiongbin Lu
Xiongbin Lu Indiana University
John N. Weinstein
John N. Weinstein The University of Texas MD Anderson Cancer Center
Julie M. Gastier-Foster
Julie M. Gastier-Foster Baylor College of Medicine
Gad Getz
Gad Getz Broad Institute
Donna M. Muzny
Donna M. Muzny Baylor College of Medicine
Matthew Meyerson
Matthew Meyerson Harvard University

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