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D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
12822
World Ranking
11954
National Ranking
5130

Overview

Xiongbin Lu is a researcher affiliated with Indiana University in the United States. Their work spans the fields of biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, oncology, immunology, cancer research, and biomedical engineering.

The scientist's research topics include:

  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • RNA modifications and cancer
  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • Cancer Research and Treatments
  • Cancer Cells and Metastasis

Xiongbin Lu has contributed to a substantial number of publications, with key papers including:

  • "Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation" (2021), Journal of Clinical Investigation
  • "MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation" (2020), Journal of Clinical Investigation
  • "RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer" (2020), Gut
  • "Loss-of-Function Genetic Screening Identifies Aldolase A as an Essential Driver for Liver Cancer Cell Growth Under Hypoxia" (2021), Hepatology
  • "An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity" (2021), Nature Biomedical Engineering

The scientist frequently publishes in the following venues:

  • Cancer Research
  • Journal of Clinical Investigation
  • Nature Communications
  • Advanced Science
  • Nature Biomedical Engineering

Co-authorship is a notable aspect of their research output, with frequent collaborators including:

  • Xinna Zhang
  • Xiaoming He
  • Kevin Van der Jeught
  • Zhuolong Zhou
  • Yujing Li

Best Publications

  • p53 mutant mice that display early ageing-associated phenotypes

    Stuart D. Tyner;Sundaresan Venkatachalam;Jene Choi;Stephen Jones

  • Drug resistance and new therapies in colorectal cancer

    Kevin Van Der Jeught;Han Chen Xu;Yu Jing Li;Xiong Bin Lu

  • PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

    Xiongbin Lu;Bonnie Nannenga;Lawrence A. Donehower

  • Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

    Lifeng Yang;Abhinav Achreja;Tsz Lun Yeung;Lingegowda S. Mangala

  • The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.

    Xiongbin Lu;Ou Ma;Thuy Ai Nguyen;Stephen N. Jones

  • Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance.

    Hai Wang;Zan Gao;Xuanyou Liu;Pranay Agarwal

  • Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells

    Wei Rao;Hai Wang;Jianfeng Han;Shuting Zhao

  • The type 2C phosphatase Wip1: An oncogenic regulator of tumor suppressor and DNA damage response pathways

    Xiongbin Lu;Thuy Ai Nguyen;Sung Hwan Moon;Yolanda Darlington

  • Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells.

    Hai Wang;Pranay Agarwal;Shuting Zhao;Ronald X. Xu

  • The ATM kinase induces microRNA biogenesis in the DNA damage response.

    Xinna Zhang;Guohui Wan;Guohui Wan;Franklin G. Berger;Xiaoming He

  • TP53 loss creates therapeutic vulnerability in colorectal cancer

    Yunhua Liu;Xinna Zhang;Cecil Han;Guohui Wan

  • Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway.

    Guohui Wan;Rohit Mathur;Xiaoxiao Hu;Yunhua Liu

  • USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

    Xinna Zhang;Franklin G Berger;Jianhua Yang;Xiongbin Lu

  • Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules.

    Wujie Zhang;Kyle Gilstrap;Laying Wu;K. C. Remant Bahadur

  • miR-203 Induces Oxaliplatin Resistance in Colorectal Cancer Cells by Negatively Regulating ATM Kinase

    Yunfei Zhou;Guohui Wan;Riccardo Spizzo;Cristina Ivan

  • Oncogenic Wip1 Phosphatase Is Inhibited by miR-16 in the DNA Damage Signaling Pathway

    Xinna Zhang;Guohui Wan;Sizolwenkosi Mlotshwa;Vicki Vance

  • miRNA response to DNA damage

    Guohui Wan;Rohit Mathur;Xiaoxiao Hu;Xinna Zhang

  • Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D

    Robert C. Castellino;Massimiliano De Bortoli;Xiongbin Lu;Sung Hwan Moon

  • A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation

    Guohui Wan;Xiaoxiao Hu;Yunhua Liu;Cecil Han

  • Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery.

    Pranay Agarwal;Hai Wang;Mingrui Sun;Jiangsheng Xu

Frequent Co-Authors

Lawrence A. Donehower
Lawrence A. Donehower Baylor College of Medicine
Jianhua Yu
Jianhua Yu City Of Hope National Medical Center
Yunlong Liu
Yunlong Liu Indiana University
Anil K. Sood
Anil K. Sood The University of Texas MD Anderson Cancer Center
Pulivarthi H. Rao
Pulivarthi H. Rao Baylor College of Medicine
John P. Fisher
John P. Fisher University of Maryland, College Park
Feng Guo
Feng Guo Pennsylvania State University
Lee M. Ellis
Lee M. Ellis The University of Texas MD Anderson Cancer Center
Stephen N. Jones
Stephen N. Jones University of Massachusetts Chan Medical School
George A. Calin
George A. Calin The University of Texas MD Anderson Cancer Center

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