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Molecular Biology
USA
2025

D-Index & Metrics

Molecular Biology

D-Index
127
Citations
57837
World Ranking
206
National Ranking
125

Research.com Recognitions

  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2020 - Fellow, National Academy of Inventors

Overview

Albert J. Fornace is affiliated with Georgetown University in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, focusing primarily on the effects of radiation exposure and related biological processes.

Their work extensively covers Molecular Biology, Radiology, Nuclear Medicine and Imaging, Pulmonary and Respiratory Medicine, Oncology, and Cancer Research.

Main topics explored in their publications include:

  • Effects of Radiation Exposure
  • Radiation Therapy and Dosimetry
  • Metabolomics and Mass Spectrometry Studies
  • DNA Repair Mechanisms
  • Carcinogens and Genotoxicity Assessment
  • Cancer, Stress, Anesthesia, and Immune Response
  • Mitochondrial Function and Pathology

Fornace has coauthored works with several researchers, frequently collaborating with Shubhankar Suman, Evagelia C. Laiakis, Kamal Datta, Evan L. Pannkuk, and Heng-Hong Li.

Their research has been published in various scientific journals, with frequent contributions to Radiation Research, Life Sciences in Space Research, Metabolites, Cancers, and Current Oncology.

Recent papers by Fornace include:

  • GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis, 2022, Advances in Experimental Medicine and Biology
  • Galactic cosmic ray simulation at the NASA space radiation laboratory - Progress, challenges and recommendations on mixed-field effects, 2022, Life Sciences in Space Research
  • High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer Development, 2023, Current Oncology
  • Crohn's disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome, 2022, Genome Medicine
  • Heavy ion space radiation triggers ongoing DNA base damage by downregulating DNA repair pathways, 2020, Life Sciences in Space Research

Albert J. Fornace was recognized as a Fellow of the National Academy of Inventors in 2020.

Best Publications

  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

    Michael B. Kastan;Qimin Zhan;Wafik S. El-Deiry

  • An Information-Intensive Approach to the Molecular Pharmacology of Cancer

    John N. Weinstein;Timothy G. Myers;Patrick M. O'Connor;Stephen H. Friend

  • Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents

    Patrick M. O'Connor;Joany Jackman;Insoo Bae;Timothy G. Myers

  • Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.

    ML Smith;IT Chen;Q Zhan;I Bae

  • DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

    Hien Tran;Anne Brunet;Jill M. Grenier;Sandeep R. Datta

  • Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

    A J Fornace;D W Nebert;M C Hollander;J D Luethy

  • Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

    Bulavin Dv;Saito S;Hollander Mc;Sakaguchi K;Sakaguchi K

  • GADD45 induction of a G2/M cell cycle checkpoint

    Xin Wei Wang;Qimin Zhan;J. D. Coursen;M. A. Khan

  • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

    T G Graeber;J F Peterson;M Tsai;K Monica

  • DNA damage-inducible transcripts in mammalian cells

    A J Fornace;I Alamo;M C Hollander

  • Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

    Dmitry V. Bulavin;Yuichiro Higashimoto;Ian J. Popoff;William A. Gaarde

  • Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45.

    Qimin Zhan;M. J. Antinore;Xin Wei Wang;F. Carrier;F. Carrier

  • Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline

    Fan S;Smith Ml;Rivet Dj nd;Duba D

  • Genomic instability in Gadd45a- deficient mice

    M. C. Hollander;M. S. Sheikh;D. V. Bulavin;K. Lundgren

  • Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

    Qimin Zhan;F. Carrier;A. J. Fornace

  • The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

    Q Zhan;K A Lord;I Alamo;M C Hollander

  • Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

    Sally A Amundson;Timothy G Myers;Albert J Fornace

  • p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes.

    Martin L. Smith;James M. Ford;M. Christine Hollander;Rachel A. Bortnick

  • p53 Gene Mutations Are Associated with Decreased Sensitivity of Human Lymphoma Cells to DNA Damaging Agents

    Saijun Fan;Wafik S. El-Deiry;Insoo Bae;Jim Freeman

  • Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

    Qimin Zhan;Sajan Fan;Insoo Bae;C. Guillouf

Frequent Co-Authors

Sally A. Amundson
Sally A. Amundson Columbia University
Qimin Zhan
Qimin Zhan Peking University Stomatological Hospital
David J. Brenner
David J. Brenner Columbia University
M. Saeed Sheikh
M. Saeed Sheikh SUNY Upstate Medical University
Patrick M. O'Connor
Patrick M. O'Connor National Institutes of Health
Andrew D. Patterson
Andrew D. Patterson Pennsylvania State University
Ettore Appella
Ettore Appella National Institutes of Health
Carole L. Yauk
Carole L. Yauk University of Ottawa
Paul S. Meltzer
Paul S. Meltzer National Institutes of Health
Jeffrey M. Trent
Jeffrey M. Trent Translational Genomics Research Institute

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