World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
8305
World Ranking
16336
National Ranking
6761

Overview

M. Saeed Sheikh is affiliated with SUNY Upstate Medical University in the United States, contributing to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans several subfields, including Molecular Biology, Oncology, Cell Biology, Epidemiology, and Cancer Research.

The main research topics addressed by Saeed Sheikh include:

  • Epigenetics and DNA Methylation
  • Cell death mechanisms and regulation
  • Autophagy in Disease and Therapy
  • Endoplasmic Reticulum Stress and Disease
  • Lung Cancer Treatments and Mutations
  • Cancer, Hypoxia, and Metabolism
  • HER2/EGFR in Cancer Research

The scientist has published several research papers in diverse peer-reviewed journals. Notably, the following papers are representative of their work:

  • Antibody-drug Conjugates for Breast Cancer Treatment, 2022, Recent Patents on Anti-Cancer Drug Discovery
  • ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage, 2020, Cell Death and Disease
  • Quinovic acid purified from medicinal plant Fagonia indica mediates anticancer effects via death receptor 5, 2020, Molecular and Cellular Biochemistry
  • Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein, 2020, Cell Death and Differentiation
  • The oncogenic potential of Rab-like protein 1A (RBEL1A) GTPase: The first review of RBEL1A research with future research directions and challenges, 2023, Journal of Cancer

Frequent co-authors contributing to collaborative publications include:

  • Ying Huang
  • Harsh Patel
  • H. P. Joshi
  • Asma Umer Khayam

Themost common publication venues where Saeed Sheikh's work appears are:

  • Recent Patents on Anti-Cancer Drug Discovery
  • Cell Death and Disease
  • Molecular and Cellular Biochemistry
  • Cell Death and Differentiation
  • Journal of Cancer

The scientist's research often focuses on mechanisms of cancer cell regulation, molecular pathways involving apoptosis and autophagy, and the development of therapeutic interventions, particularly in breast cancer. Molecular targets such as p53 and pathways related to death receptor 5 and tumor-suppressive effects form a recurring theme in published work.

Best Publications

  • p53-dependent and -independent Regulation of the Death Receptor KILLER/DR5 Gene Expression in Response to Genotoxic Stress and Tumor Necrosis Factor α

    M. Saeed Sheikh;Timothy F. Burns;Ying Huang;Gen Sheng Wu

  • Mechanisms of regulation of WAF1/Cip1 gene expression in human breast carcinoma: role of p53-dependent and independent signal transduction pathways.

    M. Saeed Sheikh;Xiao Su Li;Jian Chyi Chen;Zhi Ming Shao

  • Uniform nomenclature for the mitochondrial contact site and cristae organizing system

    Nikolaus Pfanner;Martin van der Laan;Paolo Amati;Roderick A. Capaldi

  • Role of Gadd45 in apoptosis.

    M.Saeed Sheikh;M.Christine Hollander;Albert J. Fornace

  • Role of p53 family members in apoptosis.

    M. Saeed Sheikh;Albert J. Fornace

  • Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.

    Guillermo Elizondo;Pedro Fernandez-Salguero;M. Saeed Sheikh;Geum-Yi Kim

  • Insulin-like growth factor-binding protein enhancement of insulin-like growth factor-I (IGF-I)-mediated DNA synthesis and IGF-I binding in a human breast carcinoma cell line

    Jian‐Chyi ‐C Chen;Zhi‐Ming ‐M Shao;M. Saeed Sheikh;Arif Hussain

  • The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis.

    Hani Zaher;Pedro M. Fernandez-Salguero;John Letterio;M. Saeed Sheikh

  • The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract

    M Saeed Sheikh;Ying Huang;Ester A Fernandez-Salas;Wafik S El-Deiry

  • N-(4-hydroxyphenyl)retinamide (4-HPR)-mediated biological actions involve retinoid receptor-independent pathways in human breast carcinoma

    M. S. Sheikh;M. S. Sheikh;Zhi Ming Shao;Xiao Su Li;Xiao Su Li;Jose V. Ordonez

  • Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1.

    M Saeed Sheikh;Michael J Antinore;Ying Huang;Albert J Fornace

  • The p53-binding Protein MDM2 Gene Is Differentially Expressed in Human Breast Carcinoma

    M. Saeed Sheikh;Zhi Ming Shao;Arif Hussain;Joseph A. Fontana

  • Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells.

    M Saeed Sheikh;Yong Q Chen;Martin L Smith;Albert J Fornace

  • Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-alpha acquire sensitivity to growth inhibition by retinoids.

    M S Sheikh;Z M Shao;X S Li;M Dawson

  • The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis.

    Raymond D. Meng;E. Robert McDonald;M. Saeed Sheikh;Albert J. Fornace

  • CHCM1/CHCHD6, Novel Mitochondrial Protein Linked to Regulation of Mitofilin and Mitochondrial Cristae Morphology

    Jie An;Jingxue Shi;Qin He;Ki Lui

  • Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells.

    Qin He;Ying Huang;M Saeed Sheikh

  • Melanoma: Molecular Pathogenesis and Therapeutic Management.

    Yuxin Liu;M Saeed Sheikh

  • Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest.

    Rong Rong;Weixin Jin;Jennifer Zhang;M Saeed Sheikh

  • Death receptor activation complexes: it takes two to activate TNF receptor 1.

    M. Saeed Sheikh;Ying Huang

Frequent Co-Authors

Albert J. Fornace
Albert J. Fornace Georgetown University
Charles T. Roberts
Charles T. Roberts Oregon National Primate Research Center
Marcia I. Dawson
Marcia I. Dawson Sanford Burnham Prebys Medical Discovery Institute
Derek LeRoith
Derek LeRoith Icahn School of Medicine at Mount Sinai
Wafik S. El-Deiry
Wafik S. El-Deiry Brown University
David R. Clemmons
David R. Clemmons University of North Carolina at Chapel Hill
Pedro M. Fernandez-Salguero
Pedro M. Fernandez-Salguero University of Extremadura
Frank J. Gonzalez
Frank J. Gonzalez National Institutes of Health
Peter Rehling
Peter Rehling University of Göttingen
Sally A. Amundson
Sally A. Amundson Columbia University

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