Toshiyuki Sakai

Overview

Best Publications

• Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

  T Sakai;J Toguchida;N Ohtani;D W Yandell

  684
  Citations

• Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals.

  Tiina Matikainen;Gloria I. Perez;Andrea Jurisicova;Andrea Jurisicova;James K. Pru

  572
  Citations

• Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

  Masaya Ueno;Hiroshi Masutani;Roberto Jun Arai;Akira Yamauchi

  539
  Citations

• Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

  Katsunori Nakano;Takakazu Mizuno;Yoshihiro Sowa;Tetsuro Orita

  504
  Citations

• Genistein arrests cell cycle progression at G2-M.

  Yoshizumi Matsukawa;Nobuyuki Marui;Toshiyuki Sakai;Yoshiko Satomi

  501
  Citations

• CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene

  N. Ohtani-Fujita;T. Fujita;A. Aoike;N. E. Osifchin

  438
  Citations

• The effect of quercetin on cell cycle progression and growth of human gastric cancer cells.

  Mitsumori Yoshida;Toshiyuki Sakai;Nobuko Hosokawa;Nobuyuki Marui

  434
  Citations

• Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites ☆

  Yoshihiro Sowa;Tetsuro Orita;Sachie Minamikawa;Katsunori Nakano

  414
  Citations

• Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells

  Susumu Nakata;Tatsushi Yoshida;Mano Horinaka;Mano Horinaka;Takumi Shiraishi

  374
  Citations

• Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites.

  Lili Huang;Yoshihiro Sowa;Toshiyuki Sakai;Arthur B Pardee

  310
  Citations

• Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene

  Toshiyuki Sakai;Naoko Ohtani;Naoko Ohtani;Terri L. McGee;Paul D. Robbins

  297
  Citations

• Hes1 Directly Controls Cell Proliferation through the Transcriptional Repression of p27Kip1

  Kaoru Murata;Masakazu Hattori;Norihito Hirai;Yoriko Shinozuka

  284
  Citations

• ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle

  Masamitsu Yamamoto;Nobuyuki Marui;Toshiyuki Sakai;Narito Morii

  271
  Citations

• Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo.

  Takayuki Yamaguchi;Reina Kakefuda;Nobuyuki Tajima;Yoshihiro Sowa

  268
  Citations

• Flavonoids inhibit the expression of heat shock proteins

  Nobuko Hosokawa;Kazunori Hirayoshi;Akira Nakai;Ydhei Hosokawa

  259
  Citations

• Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein.

  Tatsushi Yoshida;Takumi Shiraishi;Susumu Nakata;Mano Horinaka

  248
  Citations

• Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells.

  Mano Horinaka;Tatsushi Yoshida;Takumi Shiraishi;Susumu Nakata

  240
  Citations

• Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1.

  Swadesh K. Das;Takashi Hashimoto;Kazuo Shimizu;Tatsushi Yoshida

  229
  Citations

• Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

  Christian Fischer;Hugo Sanchez-Ruderisch;Martina Welzel;Bertram Wiedenmann

  228
  Citations

• Sp1 and NF-Y Synergistically Mediate the Effect of Vitamin D3 in the p27Kip1 Gene Promoter That Lacks Vitamin D Response Elements

  Toshiaki Inoue;Jun Kamiyama;Toshiyuki Sakai

  227
  Citations