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Toshiyuki Sakai

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
17904
World Ranking
6991
National Ranking
467

Toshiyuki Sakai publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Toshiyuki Sakai sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 305 publications — 79th percentile

79% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Toshiyuki Sakai D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Toshiyuki Sakai sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 70 D-Index — 65th percentile

65% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Toshiyuki Sakai is affiliated with Kyoto Prefectural University of Medicine in Japan. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Molecular Biology, Oncology, Pathology and Forensic Medicine, Pulmonary and Respiratory Medicine, and Cancer Research.

The main topics of Toshiyuki Sakai's work include:

  • Cancer Mechanisms and Therapy
  • Lung Cancer Treatments and Mutations
  • Phagocytosis and Immune Regulation
  • Cancer, Hypoxia, and Metabolism
  • Histone Deacetylase Inhibitors Research
  • PI3K/AKT/mTOR signaling in cancer
  • Melanoma and MAPK Pathways

Frequent co-authors collaborating with Toshiyuki Sakai are:

  • Mano Horinaka
  • Tadaaki Yamada
  • Koichi Takayama
  • Yuki Katayama
  • Michihiro Mutoh

Their publications often appear in journals such as:

  • Cancers
  • Cancer Letters
  • Cancer Science
  • Molecular Cancer Therapeutics
  • Annals of Oncology

Recent notable papers authored or co-authored by Toshiyuki Sakai include:

  • "ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR -Mutated Non-Small Cell Lung Cancer", 2020, Clinical Cancer Research
  • "Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial", 2021, The Lancet. Gastroenterology & hepatology
  • "xCT Inhibition Increases Sensitivity to Vorinostat in a ROS-Dependent Manner", 2020, Cancers
  • "Citrus limon L.-Derived Nanovesicles Show an Inhibitory Effect on Cell Growth in p53-Inactivated Colorectal Cancer Cells via the Macropinocytosis Pathway", 2022, Biomedicines
  • "Oridonin inhibits SASP by blocking p38 and NF-κB pathways in senescent cells", 2021, Biochemical and Biophysical Research Communications

Best Publications

  • Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

    T Sakai;J Toguchida;N Ohtani;D W Yandell

  • Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals.

    Tiina Matikainen;Gloria I. Perez;Andrea Jurisicova;Andrea Jurisicova;James K. Pru

  • Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

    Masaya Ueno;Hiroshi Masutani;Roberto Jun Arai;Akira Yamauchi

  • Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

    Katsunori Nakano;Takakazu Mizuno;Yoshihiro Sowa;Tetsuro Orita

  • Genistein arrests cell cycle progression at G2-M.

    Yoshizumi Matsukawa;Nobuyuki Marui;Toshiyuki Sakai;Yoshiko Satomi

  • CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene

    N. Ohtani-Fujita;T. Fujita;A. Aoike;N. E. Osifchin

  • The effect of quercetin on cell cycle progression and growth of human gastric cancer cells.

    Mitsumori Yoshida;Toshiyuki Sakai;Nobuko Hosokawa;Nobuyuki Marui

  • Histone Deacetylase Inhibitor Activates the WAF1/Cip1 Gene Promoter through the Sp1 Sites ☆

    Yoshihiro Sowa;Tetsuro Orita;Sachie Minamikawa;Katsunori Nakano

  • Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells

    Susumu Nakata;Tatsushi Yoshida;Mano Horinaka;Mano Horinaka;Takumi Shiraishi

  • Activation of the p21WAF1/CIP1 promoter independent of p53 by the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through the Sp1 sites.

    Lili Huang;Yoshihiro Sowa;Toshiyuki Sakai;Arthur B Pardee

  • Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene

    Toshiyuki Sakai;Naoko Ohtani;Naoko Ohtani;Terri L. McGee;Paul D. Robbins

  • Hes1 Directly Controls Cell Proliferation through the Transcriptional Repression of p27Kip1

    Kaoru Murata;Masakazu Hattori;Norihito Hirai;Yoriko Shinozuka

  • ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle

    Masamitsu Yamamoto;Nobuyuki Marui;Toshiyuki Sakai;Narito Morii

  • Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo.

    Takayuki Yamaguchi;Reina Kakefuda;Nobuyuki Tajima;Yoshihiro Sowa

  • Flavonoids inhibit the expression of heat shock proteins

    Nobuko Hosokawa;Kazunori Hirayoshi;Akira Nakai;Ydhei Hosokawa

  • Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein.

    Tatsushi Yoshida;Takumi Shiraishi;Susumu Nakata;Mano Horinaka

  • Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells.

    Mano Horinaka;Tatsushi Yoshida;Takumi Shiraishi;Susumu Nakata

  • Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1.

    Swadesh K. Das;Takashi Hashimoto;Kazuo Shimizu;Tatsushi Yoshida

  • Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

    Christian Fischer;Hugo Sanchez-Ruderisch;Martina Welzel;Bertram Wiedenmann

  • Sp1 and NF-Y Synergistically Mediate the Effect of Vitamin D3 in the p27Kip1 Gene Promoter That Lacks Vitamin D Response Elements

    Toshiaki Inoue;Jun Kamiyama;Toshiyuki Sakai

Frequent Co-Authors

Hoyoku Nishino
Hoyoku Nishino Kyoto Prefectural University of Medicine
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Masato Kasuga
Masato Kasuga National Center For Global Health and Medicine
Motomasa Kobayashi
Motomasa Kobayashi Osaka University
Thaddeus P. Dryja
Thaddeus P. Dryja Massachusetts Eye and Ear Infirmary
Masami Ishibashi
Masami Ishibashi Chiba University
Shunji Aoki
Shunji Aoki Hyogo University of Health Sciences
Paul D. Robbins
Paul D. Robbins University of Minnesota
Junichiro Yamaguchi
Junichiro Yamaguchi Waseda University
Takayoshi Suzuki
Takayoshi Suzuki Osaka University

External Links

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Best Scientists Citing Toshiyuki Sakai

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Publications: 24

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