Jean Pierre J. Issa

What is he best known for?

The fields of study he is best known for:

• Gene
• Cancer
• DNA

DNA methylation, Methylation, Cancer research, CpG site and Cancer are his primary areas of study. His studies in DNA methylation integrate themes in fields like Carcinogenesis, Molecular biology and Epigenetics. The Methylation study combines topics in areas such as MLH1, Immunology, Promoter, Internal medicine and DNA repair.

His Internal medicine research is multidisciplinary, incorporating perspectives in Endocrinology, Oncology and Decitabine. His Cancer research research is multidisciplinary, relying on both Pathology, Tumor suppressor gene, Regulation of gene expression, Gene silencing and Colorectal cancer. Jean Pierre J. Issa interconnects CpG Island Methylator Phenotype and Microsatellite instability in the investigation of issues within CpG site.

His most cited work include:

• Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia (2799 citations)
• CpG island methylator phenotype in colorectal cancer. (2103 citations)
• ALTERATIONS IN DNA METHYLATION : A FUNDAMENTAL ASPECT OF NEOPLASIA (1794 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns DNA methylation, Methylation, Cancer research, Epigenetics and CpG site. The various areas that he examines in his DNA methylation study include Carcinogenesis, Cancer and Molecular biology. His Methylation study integrates concerns from other disciplines, such as CpG Island Methylator Phenotype, Promoter, Internal medicine, Leukemia and Colorectal cancer.

His Internal medicine research focuses on Hypomethylating agent and how it relates to Oncology. The concepts of his Cancer research study are interwoven with issues in Tumor suppressor gene, Immunology, Decitabine and Pathology. His Epigenetics research incorporates themes from Chromatin, Epigenomics, Histone and Epigenetic therapy.

He most often published in these fields:

• DNA methylation (69.08%)
• Methylation (45.99%)
• Cancer research (41.60%)

What were the highlights of his more recent work (between 2014-2021)?

• DNA methylation (69.08%)
• Epigenetics (37.98%)
• Cancer research (41.60%)

In recent papers he was focusing on the following fields of study:

Jean Pierre J. Issa spends much of his time researching DNA methylation, Epigenetics, Cancer research, Methylation and Internal medicine. Jean Pierre J. Issa is involved in the study of DNA methylation that focuses on CpG site in particular. Jean Pierre J. Issa combines subjects such as Chromatin, Epigenetic therapy and Epigenome with his study of Epigenetics.

His study on Cancer research also encompasses disciplines like

• Cancer cell which is related to area like Phenotypic screening,
• DNA demethylation that connect with fields like DNA repair. His Methylation study combines topics from a wide range of disciplines, such as Promoter, Gene expression, Computational biology and DNA sequencing. His biological study spans a wide range of topics, including Hypomethylating agent, Oncology and Decitabine.

Between 2014 and 2021, his most popular works were:

• Targeting the cancer epigenome for therapy (503 citations)
• Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer. (362 citations)
• Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study (187 citations)

In his most recent research, the most cited papers focused on:

• Gene
• Cancer
• DNA

Jean Pierre J. Issa mostly deals with DNA methylation, Epigenetics, Cancer research, Cancer and CpG site. His research integrates issues of Molecular biology and Methylation, DNA in his study of DNA methylation. His Methylation study improves the overall literature in Gene.

His Epigenetics study incorporates themes from Epigenomics, Epigenesis, Bioinformatics and Epigenome. His Cancer research research includes elements of DNA Methyltransferase Inhibitor, EZH2, Histone methylation and Decitabine. His Decitabine research includes themes of Internal medicine and Pharmacology.