World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
14359
World Ranking
10214
National Ranking
4459

Overview

Yan Xu is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research spans a variety of topics centered on pulmonary and respiratory medicine, molecular biology, and physiology, with a strong focus on neonatal respiratory health and congenital conditions affecting the lungs.

Their work covers multiple main fields of study, including Medicine and Biochemistry, Genetics and Molecular Biology. More specifically, their subfields of study include Pulmonary and Respiratory Medicine, Molecular Biology, Physiology, Surgery, and Oncology.

Xu's research addresses several key topics, such as:

  • Neonatal Respiratory Health Research
  • Congenital Diaphragmatic Hernia Studies
  • Tuberous Sclerosis Complex Research
  • Single-cell and spatial transcriptomics
  • Renal and related cancers
  • Eosinophilic Disorders and Syndromes
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

The scientist has contributed to numerous publications over the years, including the following recent papers:

  • "An integrated cell atlas of the lung in health and disease," 2023, Nature Medicine
  • "Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes," 2020, eLife
  • "T Cell Metabolism: A New Perspective on Th17/Treg Cell Imbalance in Systemic Lupus Erythematosus," 2020, Frontiers in Immunology
  • "Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis," 2022, Theranostics
  • "A census of the lung: CellCards from LungMAP," 2021, Developmental Cell

Xu's frequent co-authors include:

  • Minzhe Guo
  • Jeffrey A. Whitsett
  • Kathryn A. Wikenheiser-Brokamp
  • Shuyang Zhao
  • Joseph A. Kitzmiller

The scientist has published regularly in several journals with repeat publications in bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, American Journal of Respiratory and Critical Care Medicine, American Journal of Physiology-Lung Cellular and Molecular Physiology, and Thoracic Cancer.

Best Publications

  • Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis

    Yan Xu;Takako Mizuno;Anusha Sridharan;Yina Du

  • SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

    Gang Chen;Thomas R. Korfhagen;Yan Xu;Joseph Kitzmiller

  • Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway.

    Christopher L. Karp;Leah M. Flick;Kiwon W. Park;Samir Softic

  • Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.

    Huajing Wan;Sharon Dingle;Yan Xu;Valérie Besnard

  • SINCERA: A Pipeline for Single-Cell RNA-Seq Profiling Analysis.

    Minzhe Guo;Minzhe Guo;Hui Wang;S. Steven Potter;Jeffrey A. Whitsett

  • β-Catenin regulates differentiation of respiratory epithelial cells in vivo

    Michael L. Mucenski;Michael L. Mucenski;Jennifer M. Nation;Angela R. Thitoff;Valérie Besnard

  • Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

    Alexander W. Lange;Anusha Sridharan;Yan Xu;Barry R. Stripp

  • TTF-1 Phosphorylation Is Required for Peripheral Lung Morphogenesis, Perinatal Survival, and Tissue-specific Gene Expression

    Mario deFelice;Daniel Silberschmidt;Roberto DiLauro;Yan Xu

  • Foxa2 is required for transition to air breathing at birth

    Huajing Wan;Yan Xu;Machiko Ikegami;Mildred T. Stahlman

  • Single Cell RNA Analysis Identifies Cellular Heterogeneity and Adaptive Responses of the Lung at Birth

    Minzhe Guo;Yina Du;Jason J. Gokey;Samriddha Ray

  • Building and Regenerating the Lung Cell by Cell

    Jeffrey A. Whitsett;Tanya V. Kalin;Yan Xu;Vladimir V. Kalinichenko

  • Role of Sonic hedgehog in patterning of tracheal–bronchial cartilage and the peripheral lung

    Leigh-Anne D. Miller;Susan E. Wert;Jean C. Clark;Yan Xu

  • ERdj4 and ERdj5 Are Required for Endoplasmic Reticulum-associated Protein Degradation of Misfolded Surfactant Protein C

    Mei Dong;James P. Bridges;Karen Apsley;Yan Xu

  • SLICE: determining cell differentiation and lineage based on single cell entropy.

    Minzhe Guo;Erik L. Bao;Michael Wagner;Jeffrey A. Whitsett

  • C/EBPα is required for lung maturation at birth

    Prithy C. Martis;Jeffrey A. Whitsett;Yan Xu;Anne-Karina T. Perl

  • Kruppel-like factor 5 is required for perinatal lung morphogenesis and function.

    Huajing Wan;Fengming Luo;Fengming Luo;Susan E. Wert;Liqian Zhang

  • Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes.

    Allen Wang;Joshua Chiou;Olivier B Poirion;Justin Buchanan

  • Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation

    Priya Rajavelu;Gang Chen;Yan Xu;Joseph A. Kitzmiller

  • BAL Cell Gene Expression is Indicative of Outcome and Airway Basal Cell Involvement in Idiopathic Pulmonary Fibrosis

    Antje Prasse;Harald Binder;Jonas C. Schupp;Gian Kayser

  • Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development

    Yina Du;Joseph A Kitzmiller;Anusha Sridharan;Anne K Perl

Frequent Co-Authors

jeffrey a whitsett
jeffrey a whitsett Cincinnati Children's Hospital Medical Center
Susan E. Wert
Susan E. Wert Cincinnati Children's Hospital Medical Center
Jeffrey A. Whitsett
Jeffrey A. Whitsett Cincinnati Children's Hospital Medical Center
Vladimir V. Kalinichenko
Vladimir V. Kalinichenko Cincinnati Children's Hospital Medical Center
Machiko Ikegami
Machiko Ikegami University of Cincinnati
Nathan Salomonis
Nathan Salomonis Cincinnati Children's Hospital Medical Center
Claire A. Chougnet
Claire A. Chougnet Cincinnati Children's Hospital Medical Center
Thomas R. Korfhagen
Thomas R. Korfhagen Cincinnati Children's Hospital Medical Center
S. Steven Potter
S. Steven Potter Cincinnati Children's Hospital Medical Center
Bruce J. Aronow
Bruce J. Aronow Cincinnati Children's Hospital Medical Center

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