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Chemistry

D-Index
46
Citations
5903
World Ranking
16218
National Ranking
4041

Overview

Daniel S. Pilch is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily focuses on biochemical and molecular biological aspects of bacterial pathogens, with particular attention to bacterial genetics, antibiotic resistance, and antimicrobial strategies.

Their body of work spans 17 publications within the field of Biochemistry, Genetics and Molecular Biology, alongside five contributions related to Medicine. More specific subfields of study include Genetics, Molecular Medicine, Molecular Biology, Infectious Diseases, and Microbiology.

Key topics explored in Pilch's research include:

  • Bacterial Genetics and Biotechnology
  • Antibiotic Resistance in Bacteria
  • Antimicrobial Resistance in Staphylococcus
  • Bacterial biofilms and quorum sensing
  • RNA and protein synthesis mechanisms
  • Cancer therapeutics and mechanisms
  • Advanced biosensing and bioanalysis techniques

Daniel S. Pilch has published in several scientific venues, with frequent appearances in:

  • Antibiotics
  • Medicinal Chemistry Research
  • Journal of Bacteriology
  • ACS Chemical Biology
  • ACS Omega

Notable recent papers include:

  • Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus, 2021, Journal of Bacteriology
  • TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens, 2022, Antibiotics
  • Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus, 2023, ACS Chemical Biology
  • Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus, 2022, Medicinal Chemistry Research
  • A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens, 2024, Antibiotics

The researcher has established collaborations with multiple scientists, including frequent co-authors:

  • Eric J. Bryan
  • Edmond J. LaVoie
  • Edgar Ferrer-González
  • Jacques Y. Roberge
  • H.-Y. Sagong

Through these collaborations and publications, Pilch contributes to advancing understanding in bacterial resistance mechanisms and the development of inhibitors targeting bacterial proteins such as FtsZ and MreB. This work has implications for addressing multidrug-resistant bacterial infections, particularly those caused by Staphylococcus aureus and Gram-negative pathogens.

Best Publications

  • Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex.

    Natasa Poklar;Daniel S. Pilch;Stephen J. Lippard;Elizabeth A. Redding

  • Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

    Igor Nudelman;Annie Rebibo-Sabbah;Marina Cherniavsky;Valery Belakhov

  • Structure, stability, and thermodynamics of a short intermolecular purine-purine-pyrimidine triple helix.

    Daniel S. Pilch;Corey Levenson;Richard H. Shafer

  • Thermodynamics of aminoglycoside-rRNA recognition: the binding of neomycin-class aminoglycosides to the A site of 16S rRNA.

    Malvika Kaul;Daniel S. Pilch

  • Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties.

    D. S. Pilch;M. A. Kirolos;Xiaoyan Liu;G. E. Plum

  • Structural analysis of the (dA)10.2(dT)10 triple helix.

    Daniel S. Pilch;Corey Levenson;Richard H. Shafer

  • Nucleic acid hybridization: triplex stability and energetics.

    G E Plum;D S Pilch;S F Singleton;K J Breslauer

  • Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines

    Ajit K. Parhi;Yongzheng Zhang;Kurt W. Saionz;Padmanava Pradhan

  • Coupling of Drug Protonation to the Specific Binding of Aminoglycosides to the A Site of 16 S rRNA: Elucidation of the Number of Drug Amino Groups Involved and their Identities

    Malvika Kaul;Christopher M Barbieri;John E Kerrigan;Daniel S Pilch

  • Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences.

    Malvika Kaul;Christopher M Barbieri;Daniel S Pilch

  • Binding of a hairpin polyamide in the minor groove of DNA: Sequence-specific enthalpic discrimination

    Daniel S. Pilch;Natasa Poklar;Craig A. Gelfand;Scott M. Law

  • Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs

    Daniel S. Pilch;Chiang Yu;Darshan Makhey;Edmond J. LaVoie

  • Thermodynamics of triple helix formation: spectrophotometric studies on the d(A)10.2d(T)10 and d(C+3T4C+3).d(G3A4G3).d(C3T4C3) triple helices.

    Daniel S. Pilch;Roland Brousseau;Richard H. Shafer

  • TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

    Malvika Kaul;Lilly Mark;Yongzheng Zhang;Ajit K. Parhi

  • Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.

    Tsai K. Li;Eleanor Bathory;Edmond J. LaVoie;A. R. Srinivasan

  • Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

    Malvika Kaul;Christopher M. Barbieri;Daniel S. Pilch

  • Characterization of a Triple Helix-specific Ligand: BePI {3-methoxy-7H-8-methyl-11-[(3′-amino)propylamino]-benzo[e]pyrido[4,3-b]indole} Intercalates into Both Double-helical and Triple-helical DNA

    Daniel S. Pilch;Michael J. Waring;Jian-Sheng Sun;Michel Rougée

  • A Structural Model for the Ternary Cleavable Complex Formed between Human Topoisomerase I, DNA, and Camptothecin†

    John E. Kerrigan;Daniel S. Pilch

  • Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

    Gurpreet Singh Minhas;Daniel S. Pilch;John E. Kerrigan;Edmond J. LaVoie

  • The thermodynamics of DNA structures that contain lesions of guanine tetrads

    Daniel S Pilch;G Eric Plum;Kenneth J Breslauer

Frequent Co-Authors

Edmond J. LaVoie
Edmond J. LaVoie Rutgers, The State University of New Jersey
Kenneth J. Breslauer
Kenneth J. Breslauer Rutgers, The State University of New Jersey
Leroy F. Liu
Leroy F. Liu Taipei Medical University
Wilma K. Olson
Wilma K. Olson Rutgers, The State University of New Jersey
Eldon E. Baird
Eldon E. Baird California Institute of Technology
Peter B. Dervan
Peter B. Dervan California Institute of Technology
Nicholas E. Geacintov
Nicholas E. Geacintov New York University
Eric Westhof
Eric Westhof University of Strasbourg
Eddy Arnold
Eddy Arnold Rutgers, The State University of New Jersey

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