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Nicholas E. Geacintov

Nicholas E. Geacintov

D-Index & Metrics

Chemistry

D-Index
83
Citations
21845
World Ranking
2988
National Ranking
1002

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2010 - Fellow of the American Chemical Society
  • 1981 - Fellow of American Physical Society (APS)

Overview

Nicholas E. Geacintov is a researcher affiliated with New York University in the United States. Their work primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Molecular Biology. Their studies also extend into related subfields including Cancer Research, Oncology, Infectious Diseases, and Ecology.

The main topics of Geacintov's research include DNA Repair Mechanisms, DNA and Nucleic Acid Chemistry, and Carcinogens and Genotoxicity Assessment. Additional areas of investigation cover RNA modifications and cancer, Genomics and Chromatin Dynamics, advanced biosensing and bioanalysis techniques, and RNA research and splicing.

Geacintov has authored numerous publications, with frequent appearances in journals such as:

  • International Journal of Molecular Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • DNA repair
  • Nucleic Acids Research
  • Biochemistry

Recent papers include:

  • "Molecular dynamics simulations reveal how H3K56 acetylation impacts nucleosome structure to promote DNA exposure for lesion sensing" (2021), published in DNA repair
  • "Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair" (2022), published in Nucleic Acids Research
  • "Excision of Oxidatively Generated Guanine Lesions by Competitive DNA Repair Pathways" (2021), published in International Journal of Molecular Sciences
  • "TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer" (2021), published in International Journal of Molecular Sciences
  • "Remarkable Enhancement of Nucleotide Excision Repair of a Bulky Guanine Lesion in a Covalently Closed Circular DNA Plasmid Relative to the Same Linearized Plasmid" (2020), published in Biochemistry

Frequent co-authors in Geacintov's publications include:

  • Vladimir Shafirovich
  • Ana H. Sales
  • Suse Broyde
  • Zvi Livneh
  • Marina Kolbanovskiy

The contributions of Nicholas E. Geacintov have been recognized by several professional societies. They have been named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012, a Fellow of the American Chemical Society in 2010, and a Fellow of the American Physical Society (APS) since 1981.

Best Publications

  • NMR SOLUTION STRUCTURES OF STEREOISOMERIC COVALENT POLYCYCLIC AROMATIC CARCINOGEN-DNA ADDUCTS : PRINCIPLES, PATTERNS, AND DIVERSITY

    Nicholas E. Geacintov;Monique Cosman;Brian E. Hingerty;Shantu Amin

  • Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro

    Yanbin Zhang;Fenghua Yuan;Xiaohua Wu;Mu Wang;Mu Wang

  • Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals

    Sigal Shachar;Omer Ziv;Sharon Avkin;Sheera Adar

  • Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.

    Monique Cosman;Carlos de los Santos;Radovan Fiala;Brian E. Hingerty

  • Effect of Magnetic Field on the Fluorescence of Tetracene Crystals: Exciton Fission

    N. Geacintov;M. Pope;F. Vogel

  • Error-prone lesion bypass by human DNA polymerase η

    Yanbin Zhang;Fenghua Yuan;Xiaohua Wu;Olga Rechkoblit

  • Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping

    Richard Misiaszek;Conor Crean;Avrum Joffe;Nicholas E. Geacintov

  • The carbonate radical is a site-selective oxidizing agent of guanine in double-stranded oligonucleotides.

    Vladimir Shafirovich;Alexander Dourandin;Weidong Huang;Nicholas E. Geacintov

  • trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases.

    Olga Rechkoblit;Yanbin Zhang;Dongyu Guo;Zhigang Wang

  • Intercalation and binding of carcinogenic hydrocarbon metabolites to nucleic acids

    Ronald G. Harvey;Nicholas E. Geacintov

  • Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells THE ROLE OF DNA POLYMERASE κ

    Sharon Avkin;Moshe Goldsmith;Susana Velasco-Miguel;Susana Velasco-Miguel;Nicholas Geacintov

  • Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes.

    Martin T. Hess;Daniela Gunz;Natalia Luneva;Nicholas E. Geacintov

  • Translesion Synthesis by Human DNA Polymerase κ on a DNA Template Containing a Single Stereoisomer of dG-(+)- or dG-(−)-anti-N2-BPDE (7,8-Dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene)†

    Naomi Suzuki;Eiji Ohashi;Alexander Kolbanovskiy;Nicholas E. Geacintov

  • A sensitive probe for the detection of Zn(II) by time-resolved fluorescence.

    Maksim Royzen;Alexander Durandin;Victor G. Young;Nicholas E. Geacintov

  • Analysis of picosecond laser induced fluorescence phenomena in photosynthetic membranes utilizing a master equation approach

    G. Paillotin;C.E. Swenberg;J. Breton;N.E. Geacintov

  • Influence of benzo[a]pyrene diol epoxide chirality on solution conformations of DNA covalent adducts: the (-)-trans-anti-[BP]G.C adduct structure and comparison with the (+)-trans-anti-[BP]G.C enantiomer.

    Carlos De Los Santos;Monique Cosman;Brian E. Hingerty;Victor Ibanez

  • Solution conformation of the (+)-cis-anti-[BP]dG adduct in a DNA duplex: intercalation of the covalently attached benzo[a]pyrenyl ring into the helix and displacement of the modified deoxyguanosine.

    Monique Cosman;Carlos de los Santos;Radovan Fiala;Brian E. Hingerty

  • One-electron oxidation reactions of purine and pyrimidine bases in cellular DNA.

    Jean Cadet;J. Richard Wagner;Vladimir Shafirovich;Nicholas E. Geacintov

  • Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis

    Jianxin Wu;Liya Gu;Huixian Wang;Nicholas E. Geacintov

  • Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.

    Tonko Buterin;Martin T. Hess;Natalia Luneva;Nicholas E. Geacintov

  • p53 and p21 regulate error-prone DNA repair to yield a lower mutation load.

    Sharon Avkin;Ziv Sevilya;Leanne Toube;Nicholas Geacintov

Frequent Co-Authors

Suse Broyde
Suse Broyde New York University
Dinshaw J. Patel
Dinshaw J. Patel Memorial Sloan Kettering Cancer Center
Shantu Amin
Shantu Amin Pennsylvania State University
Ronald G. Harvey
Ronald G. Harvey University of Chicago
Jacques Breton
Jacques Breton CEA Saclay
Zvi Livneh
Zvi Livneh Weizmann Institute of Science
Yingkai Zhang
Yingkai Zhang New York University
Robert Shapiro
Robert Shapiro New York University
Hanspeter Naegeli
Hanspeter Naegeli University of Zurich

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