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Neuroscience

D-Index
93
Citations
30221
World Ranking
994
National Ranking
529

Research.com Recognitions

  • 2018 - Kavli Prize, The Kavli Foundation for their scientific discoveries of the molecular and neural mechanisms of hearing
  • 2003 - Ralph W. Gerard Prize in Neuroscience, Society for Neuroscience
  • 2002 - Fellow of the American Academy of Arts and Sciences
  • 1991 - Member of the National Academy of Sciences
  • 1985 - W. Alden Spencer Award, College of Physicians and Surgeons
  • 1976 - Fellow of Alfred P. Sloan Foundation

Overview

A. J. Hudspeth is affiliated with the Howard Hughes Medical Institute in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Neuroscience. Within these broader fields, their work focuses significantly on Molecular Biology, Cell Biology, Sensory Systems, Cellular and Molecular Neuroscience, and Atomic and Molecular Physics, and Optics.

The scientist's research topics include Hearing, Cochlea, Tinnitus, Genetics; Single-cell and spatial transcriptomics; Gene Regulatory Network Analysis; Gene expression and cancer classification; Hippo pathway signaling and YAP/TAZ; Mechanical and Optical Resonators; and Cellular Mechanics and Interactions.

Hudspeth's recent notable papers are:

  • Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues, 2021, Nature Communications
  • Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs, 2022, Proceedings of the National Academy of Sciences
  • Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs, 2020, Nature Physics
  • Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear, 2020, Annual Review of Condensed Matter Physics
  • Modeling Active Non-Markovian Oscillations, 2022, Physical Review Letters

They have frequently collaborated with several co-authors, notably Caleb C. Reagor, Nicolas Velez-Angel, Rodrigo Alonso, Nathaniel R. Kastan, and Ksenia Gnedeva.

The main publication venues where Hudspeth's work appears include bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Proceedings of the National Academy of Sciences, Nature Communications, and Nature Physics.

Throughout their career, Hudspeth has received several awards, including the Kavli Prize from The Kavli Foundation in 2018, recognizing scientific discoveries related to the molecular and neural mechanisms of hearing. Other honors include the Ralph W. Gerard Prize in Neuroscience awarded by the Society for Neuroscience in 2003, fellowship of the American Academy of Arts and Sciences in 2002, membership in the National Academy of Sciences in 1991, the W. Alden Spencer Award from the College of Physicians and Surgeons in 1985, and fellowship of the Alfred P. Sloan Foundation in 1976.

Best Publications

  • Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor

    Wolfgang Liedtke;Yong Choe;Marc A. Martí-Renom;Andrea M. Bell;Andrea M. Bell

  • How the ear's works work

    A. J. Hudspeth

  • Sensitivity, polarity, and conductance change in the response of vertebrate hair cells to controlled mechanical stimuli

    A J Hudspeth;D P Corey

  • Compliance of the hair bundle associated with gating of mechanoelectrical transduction channels in the Bullfrog's saccular hair cell

    J. Howard;A.J. Hudspeth

  • Kinetics of the receptor current in bullfrog saccular hair cells.

    DP Corey;AJ Hudspeth

  • Colocalization of ion channels involved in frequency selectivity and synaptic transmission at presynaptic active zones of hair cells

    Unknown

  • Ionic basis of the receptor potential in a vertebrate hair cell.

    D. P. Corey;A. J. Hudspeth

  • Making an Effort to Listen: Mechanical Amplification in the Ear

    A.J. Hudspeth

  • Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell

    J Howard;A J Hudspeth

  • Voltage- and ion-dependent conductances in solitary vertebrate hair cells.

    R. S. Lewis;R. S. Lewis;A. J. Hudspeth;A. J. Hudspeth

  • Integrating the active process of hair cells with cochlear function

    Hudspeth Aj

  • Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction

    N G Robertson;L Lu;S Heller;S N Merchant

  • Active hair-bundle movements can amplify a hair cell’s response to oscillatory mechanical stimuli

    Pascal Martin;A. J. Hudspeth

  • Mechanoelectrical transduction by hair cells.

    J Howard;W M Roberts;A J Hudspeth

  • Adaptation of mechanoelectrical transduction in hair cells of the bullfrog's sacculus

    RA Eatock;DP Corey;AJ Hudspeth

  • Mechanical amplification of stimuli by hair cells

    AJ Hudspeth

  • RIM Binding Proteins (RBPs) Couple Rab3-Interacting Molecules (RIMs) to Voltage-Gated Ca2+ Channels

    H. Hibino;R. Pironkova;O. Onwumere;M. Vologodskaia

  • Pulling springs to tune transduction: Adaptation by hair cells

    A.J. Hudspeth;Peter G. Gillespie

  • A model for electrical resonance and frequency tuning in saccular hair cells of the bull-frog, Rana catesbeiana.

    A J Hudspeth;R S Lewis

  • Negative hair-bundle stiffness betrays a mechanism for mechanical amplification by the hair cell.

    P. Martin;A. D. Mehta;A. J. Hudspeth

  • Putting ion channels to work: Mechanoelectrical transduction, adaptation, and amplification by hair cells

    A. J. Hudspeth;Y. Choe;A. D. Mehta;P. Martin

  • How Hearing Happens

    A.J Hudspeth

Frequent Co-Authors

Frank Jülicher
Frank Jülicher Max Planck Society
Ulrich Müller
Ulrich Müller Johns Hopkins University School of Medicine
Nicholas D. Schiff
Nicholas D. Schiff Cornell University
Bernd Fritzsch
Bernd Fritzsch University of Nebraska Medical Center
Carole M. Hackney
Carole M. Hackney University of Sheffield
Paul Avan
Paul Avan University of Clermont Auvergne
Barbara Canlon
Barbara Canlon Karolinska Institute
Robert B. Darnell
Robert B. Darnell Rockefeller University
Cynthia C. Morton
Cynthia C. Morton Brigham and Women's Hospital
Robert Fettiplace
Robert Fettiplace University of Wisconsin–Madison

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