Jeffrey R. Holt

Overview

Best Publications

• TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

  David P. Corey;David P. Corey;Jaime Garcia-Añoveros;Jeffrey R. Holt;Kelvin Y. Kwan;Kelvin Y. Kwan

  890
  Citations

• Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

  Xue Gao;Yong Tao;Yong Tao;Yong Tao;Veronica Lamas;Mingqian Huang

  570
  Citations

• Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes

  Yoshiyuki Kawashima;Gwenaëlle S.G. Géléoc;Gwenaëlle S.G. Géléoc;Kiyoto Kurima;Valentina Labay;Valentina Labay

  462
  Citations

• TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear.

  Bifeng Pan;Gwenaelle S. Géléoc;Yukako Asai;Geoffrey C. Horwitz

  435
  Citations

• Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear

  Kazuo Oshima;Kazuo Oshima;Christian M. Grimm;C. Eduardo Corrales;C. Eduardo Corrales;Pascal Senn

  407
  Citations

• A Chemical-Genetic Strategy Implicates Myosin-1c in Adaptation by Hair Cells

  Jeffrey R. Holt;Susan K.H. Gillespie;D.William Provance;Kavita Shah

  382
  Citations

• Continuous evolution of base editors with expanded target compatibility and improved activity

  Benjamin W. Thuronyi;Benjamin W. Thuronyi;Benjamin W. Thuronyi;Luke W. Koblan;Luke W. Koblan;Jonathan M. Levy;Jonathan M. Levy;Wei-Hsi Yeh;Wei-Hsi Yeh

  343
  Citations

• TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.

  Bifeng Pan;Nurunisa Akyuz;Xiao-Ping Liu;Yukako Asai

  340
  Citations

• Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

  Karl R. Koehler;Jing Nie;Emma Longworth-Mills;Xiao Ping Liu

  333
  Citations

• A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

  Lukas D Landegger;Lukas D Landegger;Lukas D Landegger;Bifeng Pan;Bifeng Pan;Charles Askew;Charles Askew;Charles Askew;Sarah J Wassmer;Sarah J Wassmer

  328
  Citations

• Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links

  Winfried Denk;Jeffrey R. Holt;Jeffrey R. Holt;Gordon M.G. Shepherd;David P. Corey;David P. Corey

  315
  Citations

• Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

  Bifeng Pan;Charles Askew;Charles Askew;Alice Galvin;Selena Heman-Ackah;Selena Heman-Ackah

  297
  Citations

• Tmc gene therapy restores auditory function in deaf mice

  Charles Askew;Charles Askew;Cylia Rochat;Bifeng Pan;Yukako Asai

  290
  Citations

• Sound Strategies for Hearing Restoration

  Gwenaëlle S. G. Géléoc;Jeffrey R. Holt

  259
  Citations

• The Very Large G-Protein-Coupled Receptor VLGR1: A Component of the Ankle Link Complex Required for the Normal Development of Auditory Hair Bundles

  JoAnn McGee;Richard J. Goodyear;D. Randy McMillan;Eric A. Stauffer

  251
  Citations

• TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia.

  Kiyoto Kurima;Seham Ebrahim;Bifeng Pan;Miloslav Sedlacek

  219
  Citations

• Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

  Bence György;Carl Nist-Lund;Bifeng Pan;Yukako Asai

  196
  Citations

• Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea.

  Andrea Lelli;Yukako Asai;Andrew Forge;Jeffrey R. Holt

  186
  Citations

• Physical and Functional Interaction between Protocadherin 15 and Myosin VIIa in Mechanosensory Hair Cells

  Mathias Senften;Martin Schwander;Piotr Kazmierczak;Concepcion Lillo

  179
  Citations

• Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.

  Carl A. Nist-Lund;Bifeng Pan;Bifeng Pan;Amy Patterson;Yukako Asai;Yukako Asai

  175
  Citations

• Generation of inner ear organoids with functional hair cells from human pluripotent stem cells

  Karl R. Koehler;Jing Nie;Emma Longworth-Mills;Xiao-Ping Liu

  0
  Citations