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Biology and Biochemistry

D-Index
53
Citations
13350
World Ranking
15991
National Ranking
6641

Overview

Albert S.B. Edge is affiliated with the Massachusetts Eye and Ear Infirmary in the United States and specializes in neuroscience, with a focus on auditory research. Their work encompasses core fields such as sensory systems, signal processing, cognitive neuroscience, molecular biology, and neurology.

The scientist's research primarily addresses topics related to hearing, cochlea, tinnitus, and genetics, alongside hearing loss and rehabilitation. Additional areas of focus include vestibular and auditory disorders, speech and audio processing, music and audio processing, ear surgery, otitis media, and marine animal studies.

Albert S.B. Edge has contributed to numerous publications, frequently appearing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Proceedings of the National Academy of Sciences, Laryngo-Rhino-Otologie, and Nature Communications.

Recent papers include:

  • Trk agonist drugs rescue noise-induced hidden hearing loss, 2020, JCI Insight
  • Regeneration of Cochlear Synapses by Systemic Administration of a Bisphosphonate, 2020, Frontiers in Molecular Neuroscience
  • A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss, 2024, Nature Communications
  • Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro, 2023, Development
  • Lin28 reprograms inner ear glia to a neuronal fate, 2020, Stem Cells

Albert S.B. Edge regularly collaborates with several researchers, including Yushi Hayashi, Katharine Fernandez, Lukas D. Landegger, Artur A. Indzhykulian, and Christopher J. Buswinka.

Best Publications

  • A promoter-level mammalian expression atlas

    Alistair R.R. Forrest;Hideya Kawaji;Michael Rehli;J. Kenneth Baillie

  • Deglycosylation of glycoproteins by trifluoromethanesulfonic acid.

    Albert S.B. Edge;Connie R. Faltynek;Liselotte Hof;Leo E. Reichert

  • Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation.

    Francis D Pagani;Harout DerSimonian;Agatha Zawadzka;Kristie Wetzel

  • Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease

    Terrence Deacon;James Schumacher;Jonathan Dinsmore;Christine Thomas

  • Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

    Kunio Mizutari;Masato Fujioka;Masato Fujioka;Masato Fujioka;Makoto Hosoya;Naomi Bramhall;Naomi Bramhall

  • Cell Therapy Attenuates Deleterious Ventricular Remodeling and Improves Cardiac Performance After Myocardial Infarction

    Mohit Jain;Harout DerSimonian;Daniel A. Brenner;Soeun Ngoy

  • Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.

    Holly A. Rees;Holly A. Rees;Holly A. Rees;Alexis C. Komor;Alexis C. Komor;Alexis C. Komor;Wei-Hsi Yeh;Joana Caetano-Lopes;Joana Caetano-Lopes

  • Differential Distribution of Stem Cells in the Auditory and Vestibular Organs of the Inner Ear

    Kazuo Oshima;Kazuo Oshima;Christian M. Grimm;C. Eduardo Corrales;C. Eduardo Corrales;Pascal Senn

  • FANTOM5 CAGE profiles of human and mouse samples

    Shuhei Noguchi;Takahiro Arakawa;Shiro Fukuda;Masaaki Furuno

  • Central Gain Restores Auditory Processing following Near-Complete Cochlear Denervation.

    Anna R. Chambers;Jennifer Resnik;Jennifer Resnik;Yasheng Yuan;Jonathon P. Whitton

  • Wnt Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea

    Fuxin Shi;Judith S. Kempfle;Albert S. B. Edge

  • Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea.

    Naomi F. Bramhall;Naomi F. Bramhall;Fuxin Shi;Fuxin Shi;Katrin Arnold;Konrad Hochedlinger

  • Engraftment and differentiation of embryonic stem cell-derived neural progenitor cells in the cochlear nerve trunk: growth of processes into the organ of Corti.

    C. Eduardo Corrales;Luying Pan;Luying Pan;Huawei Li;Huawei Li;M. Charles Liberman;M. Charles Liberman

  • In vivo base editing of post-mitotic sensory cells.

    Wei-Hsi Yeh;Hao Chiang;Hao Chiang;Holly A. Rees;Holly A. Rees;Holly A. Rees;Albert S. B. Edge

  • Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells

    Will J. McLean;Will J. McLean;Will J. McLean;Xiaolei Yin;Lin Lu;Lin Lu;Danielle R. Lenz;Danielle R. Lenz

  • Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors

    Fuxin Shi;Lingxiang Hu;Lingxiang Hu;Albert S. B. Edge;Albert S. B. Edge;Albert S. B. Edge

  • Presence of an O-glycosidically linked hexasaccharide in fetuin.

    A S Edge;R G Spiro

  • Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation

    Hideo Nagata;Masahiro Ito;Jin Cai;Albert S Edge

  • β-Catenin Up-regulates Atoh1 Expression in Neural Progenitor Cells by Interaction with an Atoh1 3′ Enhancer

    Fuxin Shi;Yen-fu Cheng;Yen-fu Cheng;Xiaohui L. Wang;Albert S.B. Edge;Albert S.B. Edge

  • Deglycosylation of glycoproteins with trifluoromethanesulphonic acid: elucidation of molecular structure and function.

    Albert S B Edge

Frequent Co-Authors

Stefan Heller
Stefan Heller Stanford University
Robert G. Spiro
Robert G. Spiro Harvard University
Daniel J. Lee
Daniel J. Lee Samsung (South Korea)
M. Charles Liberman
M. Charles Liberman Massachusetts Eye and Ear Infirmary
Juha Kere
Juha Kere Karolinska Institute
Hans Clevers
Hans Clevers Hubrecht Institute for Developmental Biology and Stem Cell Research
Frank Brombacher
Frank Brombacher University of Cape Town
Stefano Gustincich
Stefano Gustincich Italian Institute of Technology
Peter Heutink
Peter Heutink German Center for Neurodegenerative Diseases

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