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Biology and Biochemistry

D-Index
63
Citations
11972
World Ranking
10391
National Ranking
325

Overview

Renjie Chai is affiliated with Southeast University in China. Their research primarily focuses on the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with a substantial number of publications in these areas. Within these fields, their work delves into subfields such as Molecular Biology, Sensory Systems, Cellular and Molecular Neuroscience, Biomedical Engineering, and Cancer Research.

The main topics covered by Renjie Chai's research include:

  • Hearing, Cochlea, Tinnitus, Genetics
  • Neuroscience and Neural Engineering
  • RNA regulation and disease
  • Nerve injury and regeneration
  • Cancer-related molecular mechanisms research
  • Vestibular and auditory disorders
  • Hearing Loss and Rehabilitation

Their recent papers include:

  • AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial (2024), published in The Lancet
  • PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage (2021), published in Autophagy
  • Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease (2021), published in Immunity
  • AAV-Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness (2024), published in Advanced Science
  • 2D Ti3C2TxMXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells (2020), published in Acta Biomaterialia

Renjie Chai has frequently published in journals including:

  • Advanced Science
  • Cell Proliferation
  • Smart Medicine
  • Molecular Therapy
  • Frontiers in Cell and Developmental Biology

Collaborations have been an important aspect of their research, with frequent co-authors being:

  • Jieyu Qi
  • Yangnan Hu
  • Xia Gao
  • Xiaolong Fu
  • Fangzhi Tan

Best Publications

  • Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

    Renjie Chai;Bryan Kuo;Tian Wang;Eric J. Liaw

  • Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

    Brandon C. Cox;Renjie Chai;Renjie Chai;Anne Lenoir;Anne Lenoir;Zhiyong Liu;Zhiyong Liu

  • Mutations in TUBB8 and Human Oocyte Meiotic Arrest

    Ruizhi Feng;Qing Sang;Yanping Kuang;Xiaoxi Sun

  • Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior.

    Ke-qi Fan;Yi-yuan Li;Hao-li Wang;Xin-tao Mao

  • Autophagy protects auditory hair cells against neomycin-induced damage.

    Zuhong He;Lingna Guo;Yilai Shu;Qiaojun Fang

  • Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway

    Wenyan Li;Jingfang Wu;Jianming Yang;Shan Sun

  • AAV-ie enables safe and efficient gene transfer to inner ear cells

    Fangzhi Tan;Cenfeng Chu;Cenfeng Chu;Jieyu Qi;Jieyu Qi;Wenyan Li

  • Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle

    Tian Wang;Renjie Chai;Grace S. Kim;Nicole Pham

  • Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea

    Renjie Chai;Anping Xia;Tian Wang;Taha Adnan Jan

  • Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea

    L Liu;Y Chen;Y Chen;J Qi;Y Zhang;Y Zhang

  • Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea

    Wenwen Liu;Xiaochen Xu;Zhaomin Fan;Gaoying Sun

  • Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials.

    Rongrong Guo;Shasha Zhang;Miao Xiao;Fuping Qian

  • Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice.

    Yanfei Wang;Jie Li;Xuerui Yao;Xuerui Yao;Wei Li;Wei Li

  • PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damage.

    Wenwen Liu;Lei Xu;Xue Wang;Daogong Zhang

  • Critical role of spectrin in hearing development and deafness.

    Yan Liu;Jieyu Qi;Jieyu Qi;Jieyu Qi;Xin Chen;Mingliang Tang;Mingliang Tang

  • The nuclear transcription factor FoxG1 affects the sensitivity of mimetic aging hair cells to inflammation by regulating autophagy pathways.

    Zu-hong He;Sheng-yu Zou;Ming Li;Fu-ling Liao

  • Knockdown of Foxg1 in supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse cochlea

    Shasha Zhang;Yuan Zhang;Ying Dong;Lingna Guo

  • Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease.

    Ling-jie Huang;Xin-tao Mao;Yi-yuan Li;Dan-dan Liu

  • 2D Ti3C2TxMXene couples electrical stimulation to promote proliferation and neural differentiation of neural stem cells.

    Rongrong Guo;Miao Xiao;Wanyu Zhao;Shan Zhou

  • MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro

    Ruizhi Feng;Qing Sang;Yan Zhu;Wei Fu

Frequent Co-Authors

Huawei Li
Huawei Li Fudan University
Dan Li
Dan Li University of Melbourne
Jian Wang
Jian Wang Dalhousie University
Zhongze Gu
Zhongze Gu Southeast University
Hanchuan Peng
Hanchuan Peng Southeast University
Junliang Sun
Junliang Sun Peking University
Nicholas J. Cowan
Nicholas J. Cowan New York University
Eva Nogales
Eva Nogales University of California, Berkeley
Jian Zuo
Jian Zuo Creighton University
Stefan Heller
Stefan Heller Stanford University

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