2022 - Research.com Genetics and Molecular Biology in France Leader Award
2012 - Member of the National Academy of Sciences
2012 - Fellow of the Royal Society, United Kingdom
2010 - Grand prix de l'Inserm - Institut national de la santé et de la recherche médicale
2006 - Fellow of the American Academy of Arts and Sciences
2000 - Royal Netherlands Academy of Arts and Sciences
1996 - Member of Academia Europaea
Member of the European Molecular Biology Organization (EMBO)
Denis Duboule mostly deals with Genetics, Gene, Hox gene, Homeobox and Regulation of gene expression. HOXD13, Transcription, Homeotic gene, Genome and Locus are the core of his Genetics study. His Gene study frequently draws connections to adjacent fields such as Evolutionary biology.
His Hox gene study combines topics from a wide range of disciplines, such as Vertebrate, Gene cluster, Limb development and Cell biology. His work on HNF1B, EMX2 and Iroquois homeobox factor as part of general Homeobox study is frequently connected to Order and Acanthostega, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them. His biological study spans a wide range of topics, including Chromatin, Ectoderm, Subfamily and Hindbrain.
Denis Duboule mainly investigates Hox gene, Genetics, Gene, Enhancer and Regulation of gene expression. His Hox gene research incorporates themes from Evolutionary biology, Homeobox, Vertebrate, Chromatin and Cell biology. His Vertebrate research includes themes of Morphogenesis and Anatomy.
His study in Transcription, Phenotype, Genome, Transgene and Gene cluster is carried out as part of his studies in Genetics. His Gene study is mostly concerned with Locus, Limb development, Gene expression, Regulatory sequence and Transcription factor. His study in Enhancer is interdisciplinary in nature, drawing from both Computational biology and Transcriptional regulation.
His primary areas of investigation include Gene, Enhancer, Chromatin, Hox gene and Cell biology. His Gene research entails a greater understanding of Genetics. His Enhancer research integrates issues from Phenotype, Computational biology and Limb development.
The various areas that he examines in his Chromatin study include Developmental biology, CTCF, Regulatory sequence and Genomics. Within one scientific family, Denis Duboule focuses on topics pertaining to CRISPR under Hox gene, and may sometimes address concerns connected to Long non-coding RNA. His study on Ectoderm, Limb bud and Progenitor cell is often connected to Growth differentiation factor as part of broader study in Cell biology.
Denis Duboule mainly focuses on Enhancer, Gene, Hox gene, Chromatin and CTCF. His work carried out in the field of Enhancer brings together such families of science as Computational biology and Limb development. His Gene study is focused on Genetics in general.
His work on Mutant and Embryonic stem cell as part of general Genetics study is frequently linked to Alternative strategy, bridging the gap between disciplines. His Hox gene research includes elements of Mesoderm and Cell biology. His research investigates the connection between Chromatin and topics such as Developmental biology that intersect with problems in Regulatory sequence, Transcriptional response, Stem cell, Neuroscience and Genomics.
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The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.
Nicolas Preitner;Francesca Damiola;Luis-Lopez-Molina;Joszef Zakany.
The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
D. Duboule;P. Dollé.
The EMBO Journal (1989)
Coordinate expression of the murine Hox-5 complex homoeobox-containing genes during limb pattern formation.
Pascal Dollé;Juan-Carlos Izpisúa-Belmonte;Hildegard Falkenstein;Armand Renucci.
Temporal colinearity and the phylotypic progression: a basis for the stability of a vertebrate Bauplan and the evolution of morphologies through heterochrony
Organizing Axes in Time and Space; 25 Years of Colinear Tinkering
Marie Kmita;Denis Duboule.
Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs
Pascal Dollé;Andrée Dierich;Marianne LeMeur;Thomas Schimmang.
The rise and fall of Hox gene clusters
A Global Control Region Defines a Chromosomal Regulatory Landscape Containing the HoxD Cluster
François Spitz;Federico Gonzalez;Denis Duboule.
Impaired skin wound healing in peroxisome proliferator–activated receptor (PPAR)α and PPARβ mutant mice
Liliane Michalik;Béatrice Desvergne;Nguan Soon Tan;Sharmila Basu-Modak.
Journal of Cell Biology (2001)
Colinearity and functional hierarchy among genes of the homeotic complexes
Denis Duboule;Gines Morata.
Trends in Genetics (1994)
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