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Mario R. Capecchi

Mario R. Capecchi

D-Index & Metrics

Genetics

D-Index
118
Citations
55708
World Ranking
409
National Ranking
211

Research.com Recognitions

  • 2015 - Member of the National Academy of Medicine (NAM)
  • 2010 - Fellow of the American Academy of Microbiology Genetics and Molecular Biology
  • 2009 - Fellow of the American Academy of Arts and Sciences
  • 2008 - Distinguished Scientist Award, American Heart Association
  • 2007 - Nobel Prize for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells
  • 2003 - Member of the European Academy of Sciences
  • 2001 - US President's National Medal of Science "For his groundbreaking research which has revolutionized biomedical research and provided a powerful tool for understanding disease mechanisms and gene functions.", Presented by President George W. Bush in a White House East Room ceremony on June 12, 2002.
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 1996 - Kyoto Prize in Life sciences Production of Knockout Mice through the Development of Gene Targeting Technique and Outstanding Contribution to Elucidation of Gene Function
  • 1994 - Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation
  • 1993 - Canada Gairdner International Award
  • 1991 - Member of the National Academy of Sciences

Overview

Mario R. Capecchi is affiliated with the University of Utah in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and neuroscience. The main topics of their work include neurogenesis and neuroplasticity mechanisms, pluripotent stem cells research, CRISPR and genetic engineering, neuroinflammation and neurodegeneration mechanisms, sarcoma diagnosis and treatment, histiocytic disorders and treatments, and zebrafish biomedical research applications.

Capecchi's publications have appeared in several scientific venues, with frequent contributions to Neural Development, Molecular Psychiatry, Journal of Clinical Investigation, bioRxiv (Cold Spring Harbor Laboratory), and Ophthalmology.

  • Neural Development
  • Molecular Psychiatry
  • Journal of Clinical Investigation
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Ophthalmology

They have collaborated often with several coauthors, including Hyung-song Nam, Simon Titen, Jared J. Barrott, Yanliang Wang, and Anne M. Boulet.

  • Hyung-song Nam
  • Simon Titen
  • Jared J. Barrott
  • Yanliang Wang
  • Anne M. Boulet

Recent papers authored by Capecchi or their coauthors include the following:

  • "Lrig1 expression prospectively identifies stem cells in the ventricular-subventricular zone that are neurogenic throughout adult life," 2020, Neural Development
  • "ETV4 and ETV5 drive synovial sarcoma through cell cycle and DUX4 embryonic pathway control," 2021, Journal of Clinical Investigation
  • "The clear cell sarcoma functional genomic landscape," 2021, Journal of Clinical Investigation
  • "Optogenetic stimulation of mouse Hoxb8 microglia in specific regions of the brain induces anxiety, grooming, or both," 2023, Molecular Psychiatry
  • "Comparison in Retreatments between Bevacizumab and Ranibizumab Intravitreal Injections for Retinopathy of Prematurity," 2022, Ophthalmology

Capecchi's subfields of study include molecular biology, biomedical engineering, developmental neuroscience, pulmonary and respiratory medicine, and neurology, reflecting a multidisciplinary approach within life sciences and medicine.

  • Molecular Biology
  • Biomedical Engineering
  • Developmental Neuroscience
  • Pulmonary and Respiratory Medicine
  • Neurology

The scientist has received numerous awards and honors, such as the Nobel Prize in 2007 for discoveries related to gene modifications in mice using embryonic stem cells. Other recognitions include membership in the National Academy of Medicine (2015), fellowships of the American Academy of Microbiology (2010), the American Academy of Arts and Sciences (2009), and the American Association for the Advancement of Science (2001).

  • Member of the National Academy of Medicine (NAM), 2015
  • Fellow of the American Academy of Microbiology, 2010
  • Fellow of the American Academy of Arts and Sciences, 2009
  • Distinguished Scientist Award, American Heart Association, 2008
  • Nobel Prize, 2007
  • Member of the European Academy of Sciences, 2003
  • Fellow of the American Association for the Advancement of Science (AAAS), 2001
  • Albert Lasker Award for Basic Medical Research, 2001
  • US President's National Medal of Science, 2001
  • Kyoto Prize in Life sciences, 1996
  • Alfred P. Sloan Jr. Prize, 1994
  • Canada Gairdner International Award, 1993
  • Member of the National Academy of Sciences, 1991

Best Publications

  • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

    Kirk R. Thomas;Mario R. Capecchi

  • Altering the genome by homologous recombination.

    Mario R. Capecchi

  • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

    Suzanne L. Mansour;Kirk R. Thomas;Mario R. Capecchi

  • Bmi1 is expressed in vivo in intestinal stem cells

    Eugenio Sangiorgi;Mario R Capecchi

  • High efficiency transformation by direct microinjection of DNA into cultured mammalian cells.

    Mario R. Capecchi

  • Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5

    Osamu Chisaka;Mario R. Capecchi

  • Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development.

    Kirk R. Thomas;Mario R. Capecchi

  • The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations

    Kelley S. Yan;Luis A. Chia;Xingnan Li;Akifumi Ootani

  • The new mouse genetics: altering the genome by gene targeting.

    Mario R. Capecchi

  • Gene Targeting in Mice: Functional Analysis of the Mammalian Genome for the Twenty-First Century

    Mario R. Capecchi

  • High frequency targeting of genes to specific sites in the mammalian genome

    Kirk R. Thomas;Kim R. Folger;Mario R. Capecchi

  • Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

    Akifumi Ootani;Xingnan Li;Eugenio Sangiorgi;Quoc T Ho

  • The knockout mouse project

    Christopher P. Austin;James F. Battey;Allan Bradley;Maja Bucan

  • Positive-negative selection methods and vectors

    Mario R. Capecchi;Kirk R. Thomas

  • Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton

    Deneen M. Wellik;Mario R. Capecchi

  • Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6.

    Osamu Chisaka;Teresa S. Musci;Mario R. Capecchi

  • Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and vectors for making same

    Mario R. Capecchi;Kirk R. Thomas

  • Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11.

    Allan Peter Davis;David P. Witte;Hsiu M. Hsieh-Li;S. Steven Potter

  • Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear

    Suzanne L. Mansour;Judy M. Goddard;Mario R. Capecchi

  • Retinopathy induced in mice by targeted disruption of the rhodopsin gene

    Humphries Mm;Rancourt D;Farrar Gj;Kenna P;Kenna P

Frequent Co-Authors

Kenneth E. Bernstein
Kenneth E. Bernstein Cedars-Sinai Medical Center
Rajesh Menon
Rajesh Menon University of Utah
Nancy R. Manley
Nancy R. Manley University of Georgia
Benjamin R. Arenkiel
Benjamin R. Arenkiel Baylor College of Medicine
Ning Li
Ning Li China Agricultural University
Pierre Corvol
Pierre Corvol Collège de France
Geoffrey M. Wahl
Geoffrey M. Wahl Salk Institute for Biological Studies
Anne M. Moon
Anne M. Moon University of Utah
Chu-Xia Deng
Chu-Xia Deng University of Macau
Torsten O. Nielsen
Torsten O. Nielsen University of British Columbia

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