World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
110
Citations
50041
World Ranking
5516
National Ranking
2974

Research.com Recognitions

  • 2012 - Fellow, National Academy of Inventors
  • 2008 - Distinguished Scientist Award, American Heart Association
  • 2007 - Nobel Prize for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells
  • 2003 - Member of the National Academy of Medicine (NAM)
  • 2001 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 1994 - Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation
  • 1993 - Canada Gairdner International Award
  • 1990 - Canada Gairdner International Award
  • 1986 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1984 - Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB)
  • 1971 - Member of the National Academy of Sciences

Overview

Oliver Smithies was affiliated with the University of North Carolina at Chapel Hill in the United States. Their research primarily focused on the field of Medicine, with a significant emphasis on Molecular Biology, Genetics, Cardiology and Cardiovascular Medicine, Physiology, and Endocrinology, Diabetes and Metabolism as subfields.

The scientist's work covered a range of main topics, including:

  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Estrogen and related hormone effects
  • Hormonal Regulation and Hypertension
  • Inflammatory mediators and NSAID effects
  • Birth, Development, and Health
  • Nitric Oxide and Endothelin Effects
  • Signaling Pathways in Disease

Oliver Smithies contributed to numerous publications, with key recent papers such as:

  • "Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling" (2021), published in Communications Biology
  • "The kallikrein-kinin system in diabetic nephropathy" (2020), published by UNC Libraries
  • "Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia" (2020), published by UNC Libraries
  • "Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)" (2021), published by UNC Libraries
  • "A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy" (2020), published by UNC Libraries

The majority of their publications appeared in UNC Libraries, followed by venues such as Communications Biology, OPAL (Open@LaTrobe) (La Trobe University), and The Journal of Physiological Sciences.

Frequent collaborators included:

  • Masao Kakoki
  • Hyungsuk Kim
  • Nobuyo Maeda
  • Ruriko Grant
  • Nobuyuki Takahashi

Oliver Smithies received multiple awards throughout their career, including:

  • Fellow, National Academy of Inventors (2012)
  • Distinguished Scientist Award, American Heart Association (2008)
  • Nobel Prize (2007) for discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells
  • Member of the National Academy of Medicine (NAM) (2003)
  • Albert Lasker Award for Basic Medical Research, Lasker Foundation (2001)
  • Alfred P. Sloan Jr. Prize, General Motors Cancer Research Foundation (1994)
  • Canada Gairdner International Award (1993 and 1990)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1986)
  • Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB) (1984)
  • Member of the National Academy of Sciences (1971)

Best Publications

  • Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene

    Dennis B. Lubahn;Jeffrey S. Moyer;Thomas S. Golding;John F. Couse

  • Generation and reproductive phenotypes of mice lacking estrogen receptor β

    John H. Krege;Jeffrey B. Hodgin;John F. Couse;Eva Enmark

  • An improved procedure for starch-gel electrophoresis: further variations in the serum proteins of normal individuals

    Oliver Smithies

  • Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

    Robert Langenbach;Scott G. Morham;Howard F. Tiano;Charles D. Loftin

  • Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse

    Scott G. Morham;Robert Langenbach;Charles D. Loftin;Howard F. Tiano

  • Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells

    Beverly H. Koller;Philippa Marrack;John W. Kappler;Oliver Smithies

  • An Animal Model for Cystic Fibrosis Made by Gene Targeting

    John N. Snouwaert;Kristen K. Brigman;Anne M. Latour;Nadia N. Malouf

  • Elevated blood pressures in mice lacking endothelial nitric oxide synthase

    Edward G. Shesely;Nobuyo Maeda;H.-S. Kim;Kaushik M. Desai

  • Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling.

    Radu Daniel Rudic;Edward G. Shesely;Nobuyo Maeda;Oliver Smithies

  • TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice

    Noreen C. Luetteke;Ting Hu Qiu;Robert L. Peiffer;Paula Oliver

  • Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2

    William A. Kuziel;Sharon J. Morgan;Tracey C. Dawson;Stephanie Griffin

  • Regulation of blood pressure by the type 1A angiotensin II receptor gene.

    Masaki Ito;Michael I. Oliverio;Peter J. Mannon;Christopher F. Best

  • Mouse Models of Diabetic Nephropathy

    Frank C. Brosius;Charles E. Alpers;Erwin P. Bottinger;Matthew D. Breyer

  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.

    Steven D. Crowley;Susan B. Gurley;Maria J. Herrera;Phillip Ruiz

  • Requirement of Mip-1α for an Inflammatory Response to Viral Infection

    Donald N. Cook;Melinda A. Beck;Thomas M. Coffman;Suzanne L. Kirby

  • Male–female differences in fertility and blood pressure in ACE-deficient mice

    J. H. Krege;S. W. M. John;L. L. Langenbach;J. B. Hodgin

  • Genetic control of blood pressure and the angiotensinogen locus.

    Hyung S Kim;John H. Krege;Kimberly D. Kluckman;John R. Hagaman

  • Homologous recombination for universal donor cells and chimeric mammalian hosts

    Raju S. Kucherlapati;Beverly H. Koller;Oliver Smithies

  • Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension

    Simon W. M. John;John H. Krege;Paula M. Oliver;John R. Hagaman

  • Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A

    Paula M. Oliver;Jennifer E. Fox;Ron Kim;Howard A. Rockman

Frequent Co-Authors

Nobuyo Maeda
Nobuyo Maeda University of North Carolina at Chapel Hill
Thomas M. Coffman
Thomas M. Coffman Duke University
Beverly H. Koller
Beverly H. Koller University of North Carolina at Chapel Hill
J. Charles Jennette
J. Charles Jennette University of North Carolina at Chapel Hill
Robert Langenbach
Robert Langenbach National Institutes of Health
Howard A. Rockman
Howard A. Rockman Duke University
Kenneth S. Korach
Kenneth S. Korach National Institutes of Health
Donald N. Cook
Donald N. Cook National Institutes of Health
Simon W. M. John
Simon W. M. John Columbia University
Raju Kucherlapati
Raju Kucherlapati Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For those interested in healthcare but not ready to commit to medical school, several flexible online pathways are available. Many students begin with specialized programs like financial aid for medical billing and coding, providing a quicker entry into administrative roles in health services.

Aspiring nurses can also get started without the traditional roadblocks. For example, some choose an lpn school without teas test, which allows them to bypass common pre-admission exams and start their nursing journey sooner.

Those interested in the business side of healthcare may consider a degree in healthcare administration to prepare for management roles in hospitals and clinics.

Additionally, registered nurses can take advantage of adn to np bridge programs, enabling a faster transition from an associate degree to a nurse practitioner role. These alternative paths allow for progress in healthcare careers with flexible schedules and varying educational commitments.

Best Scientists Citing Oliver Smithies

Recently Published Articles