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Genetics

D-Index
57
Citations
13736
World Ranking
3395
National Ranking
171

Overview

Yann Herault is affiliated with the Institute of Genetics and Molecular and Cellular Biology in France. Their research primarily focuses on areas within Biochemistry, Genetics and Molecular Biology, and Medicine. These fields encompass significant work in Molecular Biology, Genetics, Public Health, Environmental and Occupational Health, Physiology, and Cognitive Neuroscience.

The main topics of Yann Herault's research include:

  • Genetics and Neurodevelopmental Disorders
  • Down syndrome and intellectual disability research
  • Congenital heart defects research
  • CRISPR and Genetic Engineering
  • Genomic variations and chromosomal abnormalities
  • Autism Spectrum Disorder Research
  • Genomics and Rare Diseases

Yann Herault has published extensively, particularly in peer-reviewed journals and preprint servers. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Mammalian Genome
  • Scientific Reports
  • PLoS Genetics
  • Biomedicines

Notable recent papers authored or co-authored by Yann Herault are:

  • "Human and mouse essentiality screens as a resource for disease gene discovery" (2020, Nature Communications)
  • "A resource of targeted mutant mouse lines for 5,061 genes" (2021, Nature Genetics)
  • "Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome" (2021, Genes)
  • "Overproduction of hydrogen sulfide, generated by cystathionine β-synthase, disrupts brain wave patterns and contributes to neurobehavioral dysfunction in a rat model of down syndrome" (2022, Redox Biology)
  • "Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models" (2021, Molecular Autism)

Yann Herault has collaborated frequently with colleagues in the field. Some of the most frequent co-authors include:

  • Marie-Christine Birling
  • Tania Sorg
  • Martin Hrabě de Angelis
  • Véronique Brault
  • Mohammed Selloum

Best Publications

  • High-throughput discovery of novel developmental phenotypes

    Mary E. Dickinson;Ann M. Flenniken;Xiao Ji;Lydia Teboul

  • Distinct fibroblast lineages determine dermal architecture in skin development and repair

    Ryan R. Driskell;Ryan R. Driskell;Beate M. Lichtenberger;Beate M. Lichtenberger;Esther Hoste;Kai Kretzschmar;Kai Kretzschmar

  • A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

    Michelle M Simon;Simon Greenaway;Jacqueline K White;Helmut Fuchs

  • The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

    Joan Barau;Aurélie Teissandier;Aurélie Teissandier;Natasha Zamudio;Stéphanie Roy

  • Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

    Rafael De la Torre;Susana De Sola;Meritxell Pons;Arnaud Duchon

  • The mammalian gene function resource: the international knockout mouse consortium

    Allan Bradley;Konstantinos Anastassiadis;Abdelkader Ayadi;James F. Battey

  • Domains of genome-wide gene expression dysregulation in Down/'s syndrome

    Audrey Letourneau;Federico A. Santoni;Ximena Bonilla;M. Reza Sailani

  • Prevalence of sexual dimorphism in mammalian phenotypic traits

    Natasha A. Karp;Natasha A. Karp;Jeremy Mason;Arthur L. Beaudet;Yoav Benjamini

  • Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs

    Marie Kmita;Nadine Fraudeau;Yann Hérault;Yann Hérault;Denis Duboule

  • Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

    Arnaud Duchon;Matthieu Raveau;Claire Chevalier;Valérie Nalesso

  • Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

    Terrence F Meehan;Nathalie Conte;David B West;Julius O Jacobsen

  • Rodent models in Down syndrome research: impact and future opportunities.

    Yann Herault;Jean M. Delabar;Elizabeth M. C. Fisher;Elizabeth M. C. Fisher;Victor L. J. Tybulewicz

  • Engineering chromosomes in mice through targeted meiotic recombination (TAMERE).

    Yann Hérault;Minoo Rassoulzadegan;François Cuzin;Denis Duboule.

  • Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice:

    J. Braudeau;J. Braudeau;B. Delatour;B. Delatour;A. Duchon;P. Lopes Pereira

  • DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome

    Arnaud Duchon;Yann Herault

  • DYRK1A: a master regulatory protein controlling brain growth.

    Fayçal Guedj;Patricia Lopes Pereira;Sonia Najas;Maria-Jose Barallobre

  • Down Syndrome: From Understanding the Neurobiology to Therapy

    Katheleen Gardiner;Yann Herault;Ira T. Lott;Stylianos E. Antonarakis

  • Genetics of dark skin in mice

    Karen R. Fitch;Kelly A. McGowan;Catherine D. van Raamsdonk;Helmut Fuchs

  • Aneuploidy: From a Physiological Mechanism of Variance to Down Syndrome

    Mara Dierssen;Yann Herault;Xavier Estivill

  • Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes

    Y. Herault;N. Fraudeau;J. Zakany;D. Duboule

Frequent Co-Authors

Colin McKerlie
Colin McKerlie Hospital for Sick Children
Denis Duboule
Denis Duboule Collège de France
Kevin C K Lloyd
Kevin C K Lloyd University of California, Davis
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Helen Parkinson
Helen Parkinson European Bioinformatics Institute
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Damian Smedley
Damian Smedley Queen Mary University of London
Steve D.M. Brown
Steve D.M. Brown Medical Research Council
David J. Adams
David J. Adams Wellcome Sanger Institute
Arthur L. Beaudet
Arthur L. Beaudet Baylor College of Medicine

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