World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
9193
World Ranking
16732
National Ranking
589

Overview

Colin McKerlie is affiliated with the Hospital for Sick Children in Canada and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans various subfields including molecular biology, genetics, radiology, nuclear medicine and imaging, spectroscopy, and physiology.

The scientific topics they have explored cover a range of areas such as:

  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Molecular Biology Techniques and Applications
  • Animal Genetics and Reproduction
  • Advanced Proteomics Techniques and Applications
  • Adipose Tissue and Metabolism
  • Bioinformatics and Genomic Networks

McKerlie's recent publications include:

  • Human and mouse essentiality screens as a resource for disease gene discovery, 2020, Nature Communications
  • A resource of targeted mutant mouse lines for 5,061 genes, 2021, Nature Genetics
  • The Deep Genome Project, 2020, Genome Biology
  • Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density, 2020, PLoS Genetics
  • High-throughput discovery of genetic determinants of circadian misalignment, 2020, PLoS Genetics

The scientist frequently publishes in the following venues:

  • Mammalian Genome
  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Genetics
  • Scientific Reports
  • Investigative Ophthalmology & Visual Science

Collaborations have been a notable element of their research, working often with:

  • Lauryl M. J. Nutter
  • Ann M. Flenniken
  • K. C. Kent Lloyd
  • Martin Hrabě de Angelis
  • Yann Hérault

Best Publications

  • High-throughput discovery of novel developmental phenotypes

    Mary E. Dickinson;Ann M. Flenniken;Xiao Ji;Lydia Teboul

  • Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

    Danielle F. Cano-Gauci;Danielle F. Cano-Gauci;Howard H. Song;Howard H. Song;Huiling Yang;Huiling Yang;Colin McKerlie

  • The mammalian gene function resource: the international knockout mouse consortium

    Allan Bradley;Konstantinos Anastassiadis;Abdelkader Ayadi;James F. Battey

  • Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia.

    Ming Chen;Darrell J. Tomkins;Wojtek Auerbach;Colin McKerlie

  • C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a

    Nien Jung Chen;Christine Mirtsos;Daniel Suh;Yong Chen Lu

  • Prevalence of sexual dimorphism in mammalian phenotypic traits

    Natasha A. Karp;Natasha A. Karp;Jeremy Mason;Arthur L. Beaudet;Yoav Benjamini

  • A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia

    Ann M. Flenniken;Lucy R. Osborne;Lucy R. Osborne;Nicole Anderson;Nadia Ciliberti

  • Atelectasis Causes Alveolar Injury in Nonatelectatic Lung Regions

    Shinya Tsuchida;Doreen Engelberts;Vanya Peltekova;Natalie Hopkins

  • Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia

    Jasmine C.Y. Wong;Noa Alon;Colin Mckerlie;Jun R. Huang

  • Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

    Terrence F Meehan;Nathalie Conte;David B West;Julius O Jacobsen

  • LUNG DISEASE IN MICE WITH CYSTIC FIBROSIS

    G Kent;R Iles;C E Bear;L J Huan

  • Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

    David Ng;Graham M Pitcher;Graham M Pitcher;Rachel K Szilard;Andréa Sertié

  • Early changes in lung gene expression due to high tidal volume

    Ian B. Copland;Brian P. Kavanagh;Doreen Engelberts;Colin McKerlie

  • Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1

    Robert L. Chow;Bela Volgyi;Rachel K. Szilard;David Ng

  • Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

    Martin Hrabě de Angelis;George Nicholson;Mohammed Selloum;Jacqueline K White

  • Lung recruitment and lung volume maintenance: a strategy for improving oxygenation and preventing lung injury during both conventional mechanical ventilation and high-frequency oscillation

    Peter Rimensberger;Jean-Claude Pache;C McKerlie;H Frndova

  • A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.

    Michael R. Bowl;Michelle M. Simon;Neil J. Ingham;Neil J. Ingham;Simon Greenaway

  • High tidal volume ventilation causes different inflammatory responses in newborn versus adult lung.

    Ian B. Copland;Francisco Martinez;Brian P. Kavanagh;Doreen Engelberts

  • Effects of cryopreservation on sperm quality, nuclear DNA integrity, in vitro fertilization, and in vitro embryo development in the mouse

    Cengiz Yildiz;Palma Ottaviani;Napoleon Law;Renise Ayearst

  • N-Glycan Processing Deficiency Promotes Spontaneous Inflammatory Demyelination and Neurodegeneration

    Sung-Uk Lee;Ani Grigorian;Judy Pawling;I-Ju Chen

Frequent Co-Authors

Kevin C K Lloyd
Kevin C K Lloyd University of California, Davis
Yann Herault
Yann Herault Institute of Genetics and Molecular and Cellular Biology
Helen Parkinson
Helen Parkinson European Bioinformatics Institute
Steve D.M. Brown
Steve D.M. Brown Medical Research Council
Damian Smedley
Damian Smedley Queen Mary University of London
Paul Flicek
Paul Flicek The Jackson Laboratory
Je Kyung Seong
Je Kyung Seong Seoul National University
Wolfgang Wurst
Wolfgang Wurst German Center for Neurodegenerative Diseases
Martin Hrabé de Angelis
Martin Hrabé de Angelis Technical University of Munich
Arthur L. Beaudet
Arthur L. Beaudet Baylor College of Medicine

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