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D-Index & Metrics

Chemistry

D-Index
45
Citations
6638
World Ranking
16543
National Ranking
4112

Overview

William H. Pearson is affiliated with the University of Michigan-Ann Arbor in the United States. Their research spans several interconnected scientific fields, including Medicine, Immunology and Microbiology, and Agricultural and Biological Sciences. The subfields of study that Pearson focuses on include Immunology, Insect Science, Epidemiology, Molecular Biology, and Infectious Diseases.

The main topics covered in Pearson's research involve Invertebrate Immune Response Mechanisms, Insect symbiosis and bacterial influences, Mycobacterium research and diagnosis, Tuberculosis Research and Epidemiology, Gut microbiota and health, Neurobiology and Insect Physiology Research, and Insect Utilization and Effects.

Pearson has contributed to several recent publications that reflect their research interests and expertise. Notable papers include:

  • Mycobacterium abscessus pathogenesis identified by phenogenomic analyses, 2022, Nature Microbiology
  • Infection increases activity via Toll dependent and independent mechanisms in Drosophila melanogaster, 2022, PLoS Pathogens
  • High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster, 2024, PLoS Pathogens
  • Targeting de novo purine biosynthesis for tuberculosis treatment, 2025, Nature
  • High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster, 2023, bioRxiv (Cold Spring Harbor Laboratory)

Pearson collaborates frequently with several co-authors, indicating a network of research partnerships. The most frequent co-authors include Marc Dionne, Katrin Kierdorf, Lucas Boeck, Sophie Burbaud, and Jasper Sangen. These collaborative efforts often contribute to multidisciplinary studies within Pearson's areas of focus.

The primary venues for Pearson's publications reflect their active engagement in both preprint and peer-reviewed scientific communities. The frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • Nature Microbiology
  • Nature
  • Proceedings of the National Academy of Sciences

Best Publications

  • Synthetic applications of 1,3-dipolar cycloaddition chemistry toward heterocycles and natural products

    Albert Padwa;William H. Pearson

  • Configurational stability of chiral, nonconjugated nitrogen-substituted organolithium compounds generated by tin-lithium exchange of N-[(1-tri-n-butylstannyl)alkyl]imidazolidin-2-ones and -oxazolidin-2-ones

    William H. Pearson;Aline C. Lindbeck;Jeff W. Kampf

  • Pyrrolo-dC and pyrrolo-C: fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides ☆

    David A. Berry;Kee-Yong Jung;Dean S. Wise;Anthony D. Sercel

  • Chelation-controlled facially selective cyclocondensation reactions of chiral alkoxy aldehydes: syntheses of a mouse androgen and of a carbon-linked disaccharide

    Samuel J. Danishefsky;William H. Pearson;Daniel F. Harvey;Clarence J. Maring

  • Total synthesis of the Kopsia lapidilecta alkaloid (+/-)-lapidilectine B.

    William H. Pearson;Ill Young Lee;Yuan Mi;Patrick Stoy

  • Synthesis of benzo-fused 1-azabicyclo[m.n.0]alkanes via the Schmidt reaction: a formal synthesis of gephyrotoxin.

    William H. Pearson;Wen-kui Fang

  • Intramolecular Schmidt reactions of azides with carbocations: synthesis of bridged-bicyclic and fused-bicyclic tertiary amines

    William H. Pearson;Rajesh Walavalkar;Jeffrey M. Schkeryantz;Wen Kui Fang

  • Total synthesis of the Kopsia lapidilecta alkaloid (+/-)-lapidilectine B.

    William H. Pearson;Yuan Mi;Ill Young Lee;Patrick Stoy

  • Stereochemical studies on chiral, nonconjugated nitrogen-substituted carbanions generated by tin-lithium exchange

    William H. Pearson;Aline C. Lindbeck

  • Total synthesis of (.+-.)-3-deoxy-D-manno-2-octulopyranosate

    Samuel J. Danishefsky;William H. Pearson;Brigitte E. Segmuller

  • Cycloadditions of nonstabilized 2-azaallyllithiums (2-azaallyl anions) and azomethine ylides with alkenes: [3+2] Approaches to pyrrolidines and application to alkaloid total synthesis

    William H. Pearson;Patrick Stoy

  • Generation of 2-azaallyl anions by the transmetalation of N-(trialkylstannyl)methanimines. Pyrrolidine synthesis by [3 + 2] cycloadditions with alkenes

    William H. Pearson;Daniel P. Szura;Michael J. Postich

  • The intramolecular cycloaddition of azides with ω-chloroalkenes. A facile route to (-)-swainsonine and other indolizidine alkaloids

    William H. Pearson;Ko-Chung Lin

  • Synthetic Studies on Lepadiformine Using the 2-Azaallyl Anion Method.

    William H. Pearson;Yi Ren

  • Fluorous affinity purification of oligonucleotides.

    William H Pearson;David A Berry;Patrick Stoy;Kee-Yong Jung

  • The synthesis of pyrrolizidines and indolizidines by the intramolecular cycloaddition of azides with electron-rich 1,3-dienes. A synthetic equivalent of a nitrene-diene cycloaddition

    William H. Pearson;Stephen C. Bergmeier;Samir Degan;Ko Chung Lin

  • Synthesis of .beta.-amino-.alpha.-hydroxy acids via aldol condensation of a chiral glycolate enolate. A synthesis of (-)-bestatin

    William H. Pearson;Jennifer V. Hines

  • Synthesis and mannosidase inhibitory activity of 3-benzyloxymethyl analogs of swainsonine

    William H Pearson;Luyi Guo

  • Total synthesis of (+)-cocaine via desymmetrization of a meso-dialdehyde.

    Douglas M Mans;William H Pearson

  • Spiro asymmetric induction. 3. Synthesis of optically pure syn- or anti-.alpha.,.beta.-dihydroxy esters by the aldol condensation of chiral glycolate enolates

    William H. Pearson;Minn Chang Cheng

Frequent Co-Authors

Jeff W. Kampf
Jeff W. Kampf University of Michigan–Ann Arbor
Samuel J. Danishefsky
Samuel J. Danishefsky Columbia University
Barry M. Trost
Barry M. Trost Stanford University
Michael A. Marletta
Michael A. Marletta University of California, Berkeley
James W. Dennis
James W. Dennis Lunenfeld-Tanenbaum Research Institute
Albert Padwa
Albert Padwa Emory University
James P. Springer
James P. Springer MSD (United States)
Herman O. Sintim
Herman O. Sintim Purdue University West Lafayette

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