World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
76
Citations
22649
World Ranking
4205
National Ranking
240

Research.com Recognitions

  • 1995 - Bader Award, Royal Society of Chemistry (UK)

Overview

George W. J. Fleet is affiliated with the University of Oxford in the United Kingdom. Their research spans multiple fields closely related to chemistry and molecular biology, focusing extensively on carbohydrate chemistry and synthesis.

The main fields of study for George W. J. Fleet include:

  • Chemistry
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these fields, the subfields of specialty are:

  • Organic Chemistry
  • Molecular Biology
  • Materials Chemistry
  • Physiology
  • Endocrinology, Diabetes and Metabolism

Their research addresses several key topics such as:

  • Carbohydrate Chemistry and Synthesis
  • Glycosylation and Glycoproteins Research
  • Lysosomal Storage Disorders Research
  • Synthesis of Organic Compounds
  • Diet, Metabolism, and Disease
  • Trypanosoma species research and implications
  • Enzyme Catalysis and Immobilization

George W. J. Fleet's recent publications include articles on the synthesis and biological evaluation of glycosidase inhibitors and pharmacological chaperones. Notable papers are:

  • "Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives" (2021), published in European Journal of Medicinal Chemistry
  • "5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease" (2022), Journal of Medicinal Chemistry
  • "Strategy for Designing Selective Lysosomal Acid α-Glucosidase Inhibitors: Binding Orientation and Influence on Selectivity" (2020), Molecules
  • "Stereocomplementary synthesis of casuarine and its 6-epi-, 7-epi-, and 6,7-di-epi-stereoisomers" (2021), Organic & Biomolecular Chemistry
  • "Diastereoselective Synthesis, Glycosidase Inhibition, and Docking Study of C-7-Fluorinated Casuarine and Australine Derivatives" (2022), The Journal of Organic Chemistry

Frequent collaborators include:

  • Atsushi Kato
  • Yi-Xian Li
  • Chu-Yi Yu
  • Yuna Shimadate
  • Yue-Mei Jia

Their work is often published in a range of scientific journals and databases, with regular contributions to the following venues:

  • Organic & Biomolecular Chemistry
  • European Journal of Medicinal Chemistry
  • SSRN Electronic Journal
  • Molecules
  • The Cambridge Structural Database

In recognition of their contributions to the field, George W. J. Fleet was awarded the Bader Award by the Royal Society of Chemistry (UK) in 1995.

Best Publications

  • Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application

    Naoki Asano;Robert J Nash;Russell J Molyneux;George W.J Fleet

  • Polyhydroxylated alkaloids -- natural occurrence and therapeutic applications.

    Alison A. Watson;George W.J. Fleet;Naoki Asano;Russell J. Molyneux

  • Amino-sugar glycosidase inhibitors: versatile tools for glycobiologists

    Bryan Winchester;George W.J. Fleet

  • Inhibition of HIV replication by amino-sugar derivatives.

    George W.J. Fleet;Abraham Karpas;Raymond A. Dwek;Linda E. Fellows

  • Iminosugars as therapeutic agents: recent advances and promising trends

    Robert J Nash;Atsushi Kato;Chu-Yi Yu;George Wj Fleet

  • Affinity Labelling of Antibodies with Aryl Nitrene as Reactive Group

    G. W. J. Fleet;R. R. Porter;J. R. Knowles

  • Potent competitive inhibition of α-galactosidase and α-glucosidase activity by 1,4-dideoxy-1,4-iminopentitols: syntheses of 1,4-dideoxy-1,4-imino-d-lyxitol and of both enantiomers of 1,4-dideoxy-1,4-iminoarabinitol

    G.W.J. Fleet;S.J. Nicholas;P.W. Smith;S.V. Evans

  • Glycosidase inhibition by plant alkaloids which are structural analogues of monosaccharides

    S.V. Evans;L.E. Fellows;T.K.M. Shing;T.K.M. Shing;G.W.J. Fleet;G.W.J. Fleet

  • New polyhydroxylated pyrrolizidine alkaloids from Muscari armeniacum: structural determination and biological activity

    Naoki Asano;Hiroyo Kuroi;Kyoko Ikeda;Haruhisa Kizu

  • Polyhydroxylated pyrrolidines from sugar lactomes: Synthesis of 1,4-dideoxy-1,4-imino-d-glucitol from d-galactonolactone and syntheses of 1,4-dideoxy-1,4-imino-d-allitol, 1,4-dideoxy-1,4-imino-d-ribitol, and (2s,3r,4s)-3,4-dihydroxyproline from d-gulonolactone

    George W.J. Fleet;Jong Chan Son

  • The antibody binding site. Labelling of a specific antibody against the photo-precursor of an aryl nitrene.

    G. W. J. Fleet;J. R. Knowles;R. R. Porter

  • POTENT INHIBITION OF GLYCOGEN PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE : FIRST PYRANOSE ANALOGUES OF HYDANTOCIDIN

    Claire J.F. Bichard;Edward P. Mitchell;Mark R. Wormald;Kimberley A. Watson

  • Polyhydroxylated pyrrolidine and pyrrolizidine alkaloids from Hyacinthoides non-scripta and Scilla campanulata

    Atsushi Kato;Isao Adachi;Miwa Miyauchi;Kyoko Ikeda

  • Molecular requirements of imino sugars for the selective control of N-linked glycosylation and glycosphingolipid biosynthesis

    T.D Butters;L.A.G.M van den Broek;G.W.J Fleet;T.M Krulle

  • Inhibition of mammalian digestive disaccharidases by polyhydroxy alkaloids

    A.M. Scofield;L.E. Fellows;R.J. Nash;G.W.J. Fleet

  • 10-Helical conformations in oxetane β-amino acid hexamers

    Timothy D.W Claridge;Jonathan M Goodman;Andres Moreno;Donald Angus

  • Isolation from and x-ray crystal structure of alexine, (1r,2r,3r,7s,8s)-3-hydroxymethyl-1,2,7-trihydroxypyrrolizidine [(2r,3r,4r,5s,6s)-2-hydroxymethyl-1-azabicyclo[3.3.0]octan-3,4,6-triol], a unique pyrrolizidine alkaloid

    R.J Nash;L.E Fellows;J.V Dring;G.W.J Fleet

  • Glucose Analog Inhibitors of Glycogen-Phosphorylase - the Design of Potential-Drugs for Diabetes

    Martin Jl;Veluraja K;Ross K;Johnson Ln

  • Design of inhibitors of glycogen phosphorylase: a study of alpha- and beta-C-glucosides and 1-thio-beta-D-glucose compounds.

    K. A. Watson;E. P. Mitchell;L. N. Johnson;Jong Chan Son

  • New polyhydroxylated pyrrolidine, piperidine, and pyrrolizidine alkaloids from Scilla sibirica.

    Toru Yamashita;Kayo Yasuda;Haruhisa Kizu;Yukihiko Kameda

  • Enantiospecific syntheses of deoxymannojirimycin, fagomine and 2r,5r-dihydroxymethyl-3r,4r-dihydroxypyrrolidine from D-glucose

    George W.J. Fleet;Paul W. Smith

Frequent Co-Authors

Robert J. Nash
Robert J. Nash Aberystwyth University
Atsushi Kato
Atsushi Kato University of Toyama
Mark R. Wormald
Mark R. Wormald University of Oxford
Terry D. Butters
Terry D. Butters University of Oxford
Ken Izumori
Ken Izumori Kagawa University
Naoki Asano
Naoki Asano Hokuriku University
Louise N. Johnson
Louise N. Johnson University of Oxford
Raymond A. Dwek
Raymond A. Dwek University of Oxford
Martin D. Smith
Martin D. Smith University of Oxford
Timothy D. W. Claridge
Timothy D. W. Claridge University of Oxford

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Students studying Chemistry in the USA have a range of exciting career pathways, especially in fields related to forensic science and healthcare. For those interested in working behind the scenes, becoming an autopsy technician is a viable option. The autopsy technician salary reflects a stable income with opportunities for growth, making it an appealing career choice.

Many universities offer online degrees to help students enter this growing field. Exploring online colleges for forensic science can provide flexible education options tailored to your schedule and goals.

For those inclined toward psychology within the forensic realm, numerous specialized programs emphasize the intersection of mental health and law. Pursuing forensic psychology graduate programs online offers a pathway to advanced credentials without geographic constraints.

Professionals interested in a broader scientific role within criminal investigations can review the forensic scientist salary data to understand compensation trends and career outlooks. These diverse options highlight how Chemistry majors can leverage their skills in various forensic and scientific careers through accessible online education.

Best Scientists Citing George W. J. Fleet

Trending Scientists

Recently Published Articles