What is he best known for?
The fields of study he is best known for:
- Organic chemistry
- Enzyme
- Catalysis
His primary scientific interests are in Stereochemistry, Biochemistry, Organic chemistry, Receptor and Antagonist.
His studies in Stereochemistry integrate themes in fields like Aliphatic compound, Active site, Dipeptide, Aspergillus clavatus and Tryptoquivaline.
His work in the fields of Biochemistry, such as Phosphatase, Inositol and Inositol monophosphatase, overlaps with other areas such as Metal Binding Site and Proteoglycan.
His research in the fields of Nuclear magnetic resonance spectroscopy and Cyclobutane overlaps with other disciplines such as Moniliformin.
His study in the field of Peptide hormone and GABAA receptor also crosses realms of Arginine.
James P. Springer interconnects Imidazole, Diazepam, Benzodiazepine, Cholecystokinin and Drug discovery in the investigation of issues within Antagonist.
His most cited work include:
- Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. (1298 citations)
- Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists (1114 citations)
- Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution (192 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Stereochemistry, Organic chemistry, Medicinal chemistry, Stereoselectivity and Crystal structure.
Borrowing concepts from X-ray crystallography, James P. Springer weaves in ideas under Stereochemistry.
His work on Organic chemistry deals in particular with Lithium, Aliphatic compound, Lactone, Tetronic acid and Alkylation.
He usually deals with Medicinal chemistry and limits it to topics linked to Iminium and Aldehyde.
James P. Springer works mostly in the field of Crystal structure, limiting it down to topics relating to Molecule and, in certain cases, Crystallography.
His Ketone study integrates concerns from other disciplines, such as Epoxy and Diterpene.
He most often published in these fields:
- Stereochemistry (45.65%)
- Organic chemistry (20.29%)
- Medicinal chemistry (10.14%)
What were the highlights of his more recent work (between 1986-2005)?
- Stereochemistry (45.65%)
- Organic chemistry (20.29%)
- Medicinal chemistry (10.14%)
In recent papers he was focusing on the following fields of study:
James P. Springer spends much of his time researching Stereochemistry, Organic chemistry, Medicinal chemistry, Stereoselectivity and Antagonist.
His work in the fields of Stereochemistry, such as Bicyclic molecule, Diastereomer, Lactam and Nuclear magnetic resonance spectroscopy, intersects with other areas such as X-ray crystallography.
His Medicinal chemistry research includes themes of Iminium, Aryl, Nucleophile and Acid catalysis.
His Stereoselectivity study combines topics from a wide range of disciplines, such as Sigmatropic reaction, Allylic rearrangement, Cycloaddition and Cope rearrangement.
Antagonist is a subfield of Receptor that he investigates.
James P. Springer combines subjects such as Oxytocin Antagonist, Anxiolytic, Drug discovery and GABAA receptor with his study of Peptide hormone.
Between 1986 and 2005, his most popular works were:
- Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists (1114 citations)
- Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution (192 citations)
- Structure of inositol monophosphatase, the putative target of lithium therapy. (115 citations)
In his most recent research, the most cited papers focused on:
- Organic chemistry
- Enzyme
- Catalysis
His primary areas of study are Stereochemistry, Organic chemistry, Antagonist, Biochemistry and Receptor.
In the subject of general Stereochemistry, his work in Diastereomer and Lactam is often linked to Infrared and X-ray crystallography, thereby combining diverse domains of study.
The Antagonist study combines topics in areas such as Cholecystokinin, Imidazole, Benzodiazepine and Substituent.
James P. Springer has researched Cholecystokinin in several fields, including Drug discovery and GABAA receptor.
In his works, James P. Springer performs multidisciplinary study on Biochemistry and Metal Binding Site.
The various areas that he examines in his Receptor study include Endocrinology, Oxadiazole and Diazepam.
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