What is he best known for?
The fields of study he is best known for:
- Enzyme
- Organic chemistry
- Gene
His scientific interests lie mostly in Stereochemistry, Biochemistry, Pharmacology, Enzyme inhibitor and In vitro.
His research integrates issues of hERG, Potency, Chemical synthesis and Farnesyltransferase in his study of Stereochemistry.
The concepts of his Pharmacology study are interwoven with issues in Receptor and Orexin receptor.
The Enzyme inhibitor study combines topics in areas such as Farnesyl Protein Transferase, Signal transduction, Kinase and Farnesyl-diphosphate farnesyltransferase.
As part of the same scientific family, George D. Hartman usually focuses on In vitro, concentrating on Pharmacokinetics and intersecting with IC50 and Nonanoic acid.
His biological study spans a wide range of topics, including Kinesin, Mitosis and Binding site.
His most cited work include:
- Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. (412 citations)
- Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. (249 citations)
- Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia (248 citations)
What are the main themes of his work throughout his whole career to date?
George D. Hartman mainly focuses on Stereochemistry, Biochemistry, Pharmacology, Chemical synthesis and In vitro.
The study incorporates disciplines such as Potency, Enzyme inhibitor, Aryl, Structure–activity relationship and Allosteric regulation in addition to Stereochemistry.
George D. Hartman combines subjects such as Farnesyl Protein Transferase, Transferase, Farnesyl-diphosphate farnesyltransferase and Kinase with his study of Enzyme inhibitor.
George D. Hartman has included themes like Cancer, Kinesin and Mitosis in his Biochemistry study.
His Pharmacology research includes elements of Receptor, Fibrinogen receptor and Antagonist.
The various areas that George D. Hartman examines in his Chemical synthesis study include Lactam and Carboxamide.
He most often published in these fields:
- Stereochemistry (32.59%)
- Biochemistry (20.25%)
- Pharmacology (17.78%)
What were the highlights of his more recent work (between 2009-2021)?
- Pharmacology (17.78%)
- Stereochemistry (32.59%)
- Allosteric regulation (6.42%)
In recent papers he was focusing on the following fields of study:
George D. Hartman mainly investigates Pharmacology, Stereochemistry, Allosteric regulation, Virology and Antagonist.
George D. Hartman interconnects Receptor, In vitro, Small molecule, Biochemistry and Orexin in the investigation of issues within Pharmacology.
His studies in Biochemistry integrate themes in fields like Platelet aggregation and Sulfonamide.
George D. Hartman has researched Stereochemistry in several fields, including Pyridine, Potency, Amide, Selectivity and Chemical synthesis.
When carried out as part of a general Allosteric regulation research project, his work on Allosteric modulator is frequently linked to work in Cognitive decline, therefore connecting diverse disciplines of study.
His study in Antagonist is interdisciplinary in nature, drawing from both Orexin receptor and Carboxamide.
Between 2009 and 2021, his most popular works were:
- Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia (248 citations)
- Hepatitis b antiviral agents (112 citations)
- Discovery of [(2R,5R)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties (89 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Organic chemistry
- Gene
George D. Hartman mostly deals with Pharmacology, Virology, Allosteric regulation, Receptor and Hepatitis B.
His Pharmacology research incorporates themes from Orexin receptor, Antagonist and Biochemistry.
His Antagonist study combines topics in areas such as Suvorexant, Orexin, Filorexant and Carboxamide.
His Muscarinic acetylcholine receptor study, which is part of a larger body of work in Biochemistry, is frequently linked to Cognitive decline, bridging the gap between disciplines.
His Allosteric regulation research is multidisciplinary, relying on both Penetrant, Carboxylic acid, Metabotropic glutamate receptor 2 and Stereochemistry.
Receptor is often connected to Endocrinology in his work.
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