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George D. Hartman

George D. Hartman

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Chemistry
Belgium
2025

D-Index & Metrics

Chemistry

D-Index
66
Citations
13121
World Ranking
7429
National Ranking
92

Biology and Biochemistry

D-Index
66
Citations
12831
World Ranking
8836
National Ranking
155

Research.com Recognitions

  • 2025 - Research.com Chemistry in Belgium Leader Award
  • 2022 - Research.com Chemistry in Belgium Leader Award

Overview

George D. Hartman is affiliated with Janssen (Belgium) in Belgium and has contributed to research primarily within the field of Medicine. Their work spans several subfields including Epidemiology, Molecular Biology, Hepatology, Immunology, and Infectious Diseases. The scientist's research focuses on areas related to viral infections, immune responses, and liver diseases.

The main research topics covered by George D. Hartman include:

  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Inflammasome and immune disorders
  • Interferon and immune responses
  • Tryptophan and brain disorders
  • Viral Infections and Outbreaks Research
  • Pneumocystis jirovecii pneumonia detection and treatment

Recent publications featuring George D. Hartman as an author demonstrate their active involvement in antiviral and immunology research. Selected papers include:

  • The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening, 2024, Bioorganic & Medicinal Chemistry Letters
  • P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals, 2020, ACS Medicinal Chemistry Letters

Other notable recent papers in related fields, though authored by colleagues, appear in venues where George D. Hartman is a frequent contributor:

  • Identification of a new class of HBV capsid assembly modulator, 2021, Bioorganic & Medicinal Chemistry Letters
  • Oxadiazepinone HBV capsid assembly modulators, 2021, Bioorganic & Medicinal Chemistry Letters
  • Diazepinone HBV capsid assembly modulators, 2022, Bioorganic & Medicinal Chemistry Letters

George D. Hartman collaborates with several frequent co-authors, including:

  • Rusty L. Montgomery
  • Sarah U. Tronnes
  • Rebecca C. Coll
  • Michael Marleaux
  • Inga V. Hochheiser

The scientist generally publishes in the following venues, reflecting their research focus in medicinal chemistry and experimental medicine:

  • Bioorganic & Medicinal Chemistry Letters
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Experimental Medicine
  • ACS Medicinal Chemistry Letters

Best Publications

  • Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.

    Craig W. Lindsley;Zhijian Zhao;William H. Leister;Ronald G. Robinson

  • Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

    Christopher D. Cox;Michael J. Breslin;David B. Whitman;John D. Schreier

  • Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors.

    Hartman Gd;Egbertson Ms;Halczenko W;Laswell Wl

  • Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

    Robert B. Lobell;Charles A. Omer;Marc T. Abrams;Hema G. Bhimnathwala

  • Non-peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp

    Egbertson Ms;Chang Ct;Duggan Me;Gould Rj

  • Inhibition of a mitotic motor protein: where, how, and conformational consequences

    Youwei Yan;Vinod Sardana;Bei Xu;Carl Homnick

  • Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

    Craig W. Lindsley;David D. Wisnoski;William H. Leister;Julie A. O'brien

  • Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors.

    Zhijian Zhao;William H. Leister;Ronald G. Robinson;Stanley F. Barnett

  • Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

    Christopher D Cox;Paul J Coleman;Michael J Breslin;David B Whitman

  • Hepatitis b antiviral agents

    George D. Hartman;Osvaldo A. Flores

  • Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP

    Christopher D. Cox;Michael J. Breslin;Brenda J. Mariano;Paul J. Coleman

  • Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

    Paul J. Coleman;John D. Schreier;Christopher D. Cox;Michael J. Breslin

  • Sulfonamide fibrinogen receptor antagonists

    Melissa S. Egbertson;William L. Laswell;George D. Hartman;Mark E. Duggan

  • High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

    Klaus Klumpp;Angela M. Lam;Christine Lukacs;Robert Vogel

  • New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.

    Prugh Jd;Hartman Gd;Mallorga Pj;McKeever Bm

  • Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.

    William D. Shipe;James C. Barrow;Zhi Qiang Yang;Craig W. Lindsley;Craig W. Lindsley

  • Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection

    Man Fung Yuen;Edward J. Gane;Dong Joon Kim;Frank Weilert

  • Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis.

    John H Hutchinson;Wasyl Halczenko;Karen M Brashear;Michael J Breslin

  • Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.

    B. Wesley Trotter;Kausik K. Nanda;Nathan R. Kett;Christopher P. Regan

  • Farnesyltransferase inhibitors versus Ras inhibitors

    Jackson B Gibbs;Samuel L Graham;George D Hartman;Kenneth S Koblan

Frequent Co-Authors

Nancy E. Kohl
Nancy E. Kohl Unnatural Products
Craig W. Lindsley
Craig W. Lindsley Vanderbilt University
John J. Renger
John J. Renger MSD (United States)
Jackson B. Gibbs
Jackson B. Gibbs George Washington University
Gideon A. Rodan
Gideon A. Rodan MSD (United States)
Le T. Duong
Le T. Duong MSD (United States)
Allen Oliff
Allen Oliff GlaxoSmithKline (United States)
Klaus Klumpp
Klaus Klumpp Janssen (Belgium)
Samuel Graham
Samuel Graham Georgia Institute of Technology
Christopher Cox
Christopher Cox Johns Hopkins University

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