World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
103
Citations
32727
World Ranking
1327
National Ranking
777

Research.com Recognitions

  • 2014 - Fellow, National Academy of Inventors

Overview

Said M. Sebti is affiliated with Virginia Commonwealth University in the United States. Their research spans multiple fields including Medicine, Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology. The scientist's work focuses on several subfields such as Molecular Biology, Immunology, Oncology, Radiology, Nuclear Medicine and Imaging, and Cancer Research.

Their main research topics include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Mast cells and histamine
  • Monoclonal and Polyclonal Antibodies Research
  • Cancer-related Molecular Pathways
  • Immunotherapy and Immune Responses
  • PI3K/AKT/mTOR signaling in cancer

Sebti has authored various papers published in noted journals. Recent publications include:

  • "CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function" (2020), Cancer Immunology Research
  • "Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer" (2021), Clinical Cancer Research
  • "The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells" (2020), Journal of Biological Chemistry
  • "Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results" (2021), Clinical Cancer Research
  • "Porphyrin overdrive rewires cancer cell metabolism" (2024), Life Science Alliance

Frequent co-authors collaborating with Said M. Sebti include:

  • Aslamuzzaman Kazi
  • Elizabeth M. Sagatys
  • Kelly Walton
  • Jongphil Kim
  • Nicholas J. Lawrence

The scientist publishes regularly in prominent venues such as:

  • The Journal of Immunology
  • Blood
  • Cancer Immunology Research
  • Clinical Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)

Said M. Sebti was recognized as a Fellow of the National Academy of Inventors in 2014.

Best Publications

  • Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

    Khandaker Siddiquee;Shumin Zhang;Wayne C. Guida;Michelle A. Blaskovich

  • Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

    Michelle A. Blaskovich;Jiazhi Sun;Alan Cantor;James Turkson

  • Targeting protein prenylation for cancer therapy

    Norbert Berndt;Andrew D. Hamilton;Saïd M. Sebti

  • Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

    Lin Yang;Han C. Dan;Mei Sun;Qiyuan Liu

  • Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.

    James Turkson;Declan Ryan;Joon S. Kim;Yi Zhang

  • Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

    Edwina C. Lerner;Yimin Qian;Michelle A. Blaskovich;Renae D. Fossum

  • Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

    Fraser P. Coxon;Miep H. Helfrich;Robert Van't Hof;Saïd Sebti

  • Regulation of Dendritic Cell Differentiation and Antitumor Immune Response in Cancer by Pharmacologic-Selective Inhibition of the Janus-Activated Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway

    Yulia Nefedova;Srinivas Nagaraj;Amsler Rosenbauer;Carlos Muro-Cacho

  • Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.

    Saïd M Sebti;Andrew D Hamilton

  • The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

    Kun Jiang;Domenico Coppola;Nichole C. Crespo;Santo V. Nicosia

  • Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.

    James Turkson;Tammy Bowman;Jalila Adnane;Yi Zhang

  • Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.

    Jiazhi Sun;Michelle A Blaskovich;Richard Jove;Sandra K Livingston

  • Discovery of a novel shp2 protein tyrosine phosphatase inhibitor.

    Liwei Chen;Shen Shu Sung;M. L Richard Yip;Harshani R. Lawrence

  • Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.

    Jiazhi Sun;Yimin Qian;Andrew D Hamilton;Saïd M Sebti

  • Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity

    James Turkson;Joon S. Kim;Shumin Zhang;Jing Yuan

  • Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine

    Jiazhi Sun;Michelle A. Blaskovich;David Knowles;Yimin Qian

  • Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.

    Hang Yin;Gui‐in Lee;Hyung Soon Park;Gregory A. Payne

  • MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin

    Baoli Hu;Daniele M. Gilkes;Bilal Farooqi;Said M. Sebti

  • Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion

    Jiazhi Sun;Yimin Qian;Andrew D. Hamilton;Saïd M. Sebti

  • Terphenyl-Based Bak BH3 α-Helical Proteomimetics as Low-Molecular-Weight Antagonists of Bcl-xL

    Hang Yin;Gui In Lee;Kristine A. Sedey;Olaf Kutzki

Frequent Co-Authors

Andrew D. Hamilton
Andrew D. Hamilton New York University
Jin Q. Cheng
Jin Q. Cheng University of South Florida
Jie Wu
Jie Wu Temple University
Domenico Coppola
Domenico Coppola Moffitt Cancer Center
Richard Jove
Richard Jove Nova Southeastern University
Michael H. Gelb
Michael H. Gelb University of Washington
Wesley C. Van Voorhis
Wesley C. Van Voorhis University of Washington
Frederick S. Buckner
Frederick S. Buckner University of Washington
Srikumar Chellappan
Srikumar Chellappan University of South Florida
Hong-Gang Wang
Hong-Gang Wang Pennsylvania State University

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