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Biology and Biochemistry

D-Index
59
Citations
13184
World Ranking
12481
National Ranking
5342

Overview

Srikumar Chellappan is affiliated with the University of South Florida in the United States. Their research broadly spans Biochemistry, Genetics and Molecular Biology, with additional focus in Medicine. Key subfields of their work include Molecular Biology, Cell Biology, Oncology, Cancer Research, and Pulmonary and Respiratory Medicine.

The scientist has contributed to a significant number of publications, concentrating on topics such as:

  • Ubiquitin and proteasome pathways
  • Microtubule and mitosis dynamics
  • Epigenetics and DNA Methylation
  • Cancer-related Molecular Pathways
  • Hippo pathway signaling and YAP/TAZ
  • Cancer Genomics and Diagnostics
  • Histone Deacetylase Inhibitors Research

Frequent publication venues for their work include:

  • Scientific Reports
  • Neuro-Oncology
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • Cancers
  • Cancer Gene Therapy

Collaborations have been marked by repeated co-authorship with several researchers, including:

  • Jaya Padmanabhan
  • Harold I. Saavedra
  • Biswarup Saha
  • Yainyrette Rivera-Rivera
  • Neha Jaiswal

Selected recent publications are as follows:

  • Novel HDAC11 inhibitors suppress lung adenocarcinoma stem cell self-renewal and overcome drug resistance by suppressing Sox2, 2020, Scientific Reports
  • The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells, 2021, Scientific Reports
  • Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells, 2020, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells, 2021, Cancers
  • HDAC11 activity contributes to MEK inhibitor escape in uveal melanoma, 2022, Cancer Gene Therapy

Best Publications

  • The E2F transcription factor is a cellular target for the RB protein.

    Srikumar P. Chellappan;Srikumar P. Chellappan;Scott Hiebert;Scott Hiebert;Maria Mudryj;Maria Mudryj;Jonathan M. Horowitz

  • Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

    S Chellappan;V B Kraus;B Kroger;K Munger

  • Prohibitin Induces the Transcriptional Activity of p53 and Is Exported from the Nucleus upon Apoptotic Signaling

    Gina Fusaro;Gina Fusaro;Piyali Dasgupta;Shipra Rastogi;Bharat Joshi

  • Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines

    Piyali Dasgupta;Wasia Rizwani;Smitha Pillai;Rebecca Kinkade

  • Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin

    Piyali Dasgupta;Rebecca Kinkade;Bharat Joshi;Christina DeCook

  • Nicotine induces cell proliferation by β-arrestin–mediated activation of Src and Rb–Raf-1 pathways

    Piyali Dasgupta;Shipra Rastogi;Smitha Pillai;Dalia Ordonez-Ercan

  • Nicotine-Mediated Cell Proliferation and Tumor Progression in Smoking-Related Cancers

    Courtney Schaal;Srikumar P. Chellappan

  • Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.

    James K Schwarz;Stephen H. Devoto;Eric J. Smith;Srikumar P. Chellappan

  • Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression

    Sheng Wang;Gina Fusaro;Jaya Padmanabhan;Srikumar P Chellappan

  • Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function.

    Sheng Wang;Niharika Nath;Matthew Adlam;Srikumar Chellappan

  • EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

    Sandeep Singh;Jose Trevino;Namrata Bora-Singhal;Domenico Coppola

  • Nicotine Promotes Tumor Growth and Metastasis in Mouse Models of Lung Cancer

    Rebecca Davis;Wasia Rizwani;Sarmistha Banerjee;Michelle Kovacs

  • Rb and Prohibitin Target Distinct Regions of E2F1 for Repression and Respond to Different Upstream Signals

    Sheng Wang;Niharika Nath;Gina Fusaro;Srikumar Chellappan

  • Nicotine-mediated cell proliferation and angiogenesis: new twists to an old story.

    Piyali Dasgupta;Srikumar P. Chellappan

  • YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells

    Namrata Bora-Singhal;Jonathan Nguyen;Courtney Schaal;Deepak Perumal

  • Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases.

    Sheng Wang;Niharika Nath;Audrey Minden;Srikumar Chellappan

  • Raf-1 Physically Interacts with Rb and Regulates Its Function: a Link between Mitogenic Signaling and Cell Cycle Regulation

    Sheng Wang;Richik N. Ghosh;Srikumar P. Chellappan

  • Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.

    Sandeep Singh;Smitha Pillai;Srikumar Chellappan

  • Cloning and characterization of human DP2, a novel dimerization partner of E2F.

    Yonghui Zhang;S. P. Chellappan

  • Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis.

    Gina Fusaro;Sheng Wang;Srikumar Chellappan

Frequent Co-Authors

Eric B. Haura
Eric B. Haura University of South Florida
Domenico Coppola
Domenico Coppola Moffitt Cancer Center
Said M. Sebti
Said M. Sebti Virginia Commonwealth University
Joseph R. Nevins
Joseph R. Nevins Duke University
Scott W. Hiebert
Scott W. Hiebert Vanderbilt University
Surinder K. Batra
Surinder K. Batra University of Nebraska Medical Center
John M. Koomen
John M. Koomen University of South Florida
Steven Grant
Steven Grant Virginia Commonwealth University
Michael J. Schell
Michael J. Schell University of South Florida
Kathryn Calame
Kathryn Calame Columbia University

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