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Molecular Biology

D-Index
84
Citations
30108
World Ranking
868
National Ranking
457

Overview

Scott W. Hiebert is affiliated with Vanderbilt University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad domains, the scientist has contributed extensively to subfields including Molecular Biology, Hematology, Oncology, Cancer Research, and Immunology.

Their work covers several principal topics in biomedical research, notably Protein Degradation and Inhibitors, Genomics and Chromatin Dynamics, Acute Myeloid Leukemia Research, CRISPR and Genetic Engineering, RNA modifications and cancer, Epigenetics and DNA Methylation, and Immune cells in cancer.

Scott W. Hiebert has authored multiple papers, several of which are recent and highlight their scientific focus. These include:

  • Definition of a small core transcriptional circuit regulated by AML1-ETO, 2020, Molecular Cell
  • Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors, 2020, Science Translational Medicine
  • Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia, 2020, Gene
  • Human SMARCA5 is continuously required to maintain nucleosome spacing, 2023, Molecular Cell
  • PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, and RNA polymerase pause release at select gene targets, 2022, Molecular Cell

The scientist frequently publishes in a set of journals focused on molecular and cancer biology. These publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Clinical Cancer Research
  • Gastroenterology
  • Cancer Research

Scott W. Hiebert often collaborates with a core group of co-authors, who have co-contributed to multiple publications. Notable collaborators include:

  • Kristy R. Stengel
  • Jacob Ellis
  • Monica Bomber
  • Hillary M. Layden
  • Christopher S. Williams

Best Publications

  • AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

    Tsukasa Okuda;Jan van Deursen;Scott W Hiebert;Gerard Grosveld

  • The E2F transcription factor is a cellular target for the RB protein.

    Srikumar P. Chellappan;Srikumar P. Chellappan;Scott Hiebert;Scott Hiebert;Maria Mudryj;Maria Mudryj;Jonathan M. Horowitz

  • Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4.

    Jun-Ya Kato;H. Matsushime;S. W. Hiebert;M. E. Ewen

  • Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

    T R Golub;G F Barker;S K Bohlander;S W Hiebert

  • The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.

    Scott W. Hiebert;Srikumar P. Chellappan;Jonathan M. Horowitz;Joseph R. Nevins

  • Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions.

    S Meyers;J R Downing;S W Hiebert

  • ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors

    Bart Lutterbach;Jennifer J. Westendorf;Bryan Linggi;Andrea Patten

  • Runt Homology Domain Proteins in Osteoblast Differentiation: AML3/CBFA1 Is a Major Component of a Bone-Specific Complex

    Chaitali Banerjee;Laura R. McCabe;Je-Yong Choi;Scott W. Hiebert

  • CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.

    Dong-Er Zhang;C. J. Hetherington;S. Meyers;K. L. Rhoades

  • The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation.

    S Meyers;N Lenny;S W Hiebert

  • Analysis of protein dynamics at active, stalled, and collapsed replication forks

    Bianca M. Sirbu;Frank B. Couch;Jordan T. Feigerle;Srividya Bhaskara

  • ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

    Joseph M. Amann;John Nip;David K. Strom;Bart Lutterbach

  • Deletion of Histone Deacetylase 3 reveals critical roles in S-phase progression and DNA damage control

    Srividya Bhaskara;Brenda J. Chyla;Joseph M. Amann;Sarah K. Knutson

  • PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2 beta/CBF beta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

    Issarang Nuchprayoon;Shari Meyers;Linda M. Scott;Joseph Suzow

  • Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A

    Maria Mudryj;Stephen H. Devoto;Scott W. Hiebert;Tony Hunter

  • Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

    Xuefen Chen;Iros Barozzi;Alberto Termanini;Elena Prosperini

  • Hdac3 is essential for the maintenance of chromatin structure and genome stability.

    Srividya Bhaskara;Sarah K. Knutson;Guochun Jiang;Mahesh B. Chandrasekharan

  • E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor

    Scott W. Hiebert;Martin Lipp;Joseph R. Nevins

  • Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

    Carsten Müller-Tidow;Björn Steffen;Thomas Cauvet;Lara Tickenbrock

  • Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors

    Congmei Zeng;Andre J. Van Wijnen;Janet L. Stein;Shari Meyers

Frequent Co-Authors

Keith T. Wilson
Keith T. Wilson Vanderbilt University Medical Center
Robert A. Lamb
Robert A. Lamb Northwestern University
Jane B. Lian
Jane B. Lian University of Vermont
Gary S. Stein
Gary S. Stein University of Vermont
John L. Cleveland
John L. Cleveland Moffitt Cancer Center
James R. Downing
James R. Downing St. Jude Children's Research Hospital
Janet L. Stein
Janet L. Stein University of Vermont
Xi Chen
Xi Chen University of California, Davis
Joseph R. Nevins
Joseph R. Nevins Duke University
Rupesh Chaturvedi
Rupesh Chaturvedi Jawaharlal Nehru University

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