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Biology and Biochemistry

D-Index
51
Citations
8937
World Ranking
17213
National Ranking
1353

Overview

Georges Lacaud is affiliated with the University of Manchester in the United Kingdom and has contributed extensively to research in Biochemistry, Genetics and Molecular Biology as well as Medicine. Their work spans several subfields including Molecular Biology, Hematology, Immunology, Cell Biology, and Pulmonary and Respiratory Medicine.

Their recent publications cover a variety of topics within these disciplines, including acute myeloid leukemia, hematopoietic stem cells, and molecular regulatory mechanisms. Notable papers include:

  • Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE (2021, Blood)
  • RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development (2020, eLife)
  • CUL2 LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle (2021, EMBO Reports)
  • Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia (2021, Cell Reports)
  • Contributions of Embryonic HSC-Independent Hematopoiesis to Organogenesis and the Adult Hematopoietic System (2021, Frontiers in Cell and Developmental Biology)

Lacaud's frequent coauthors include Michael Lie-A-Ling, Wen Hao Neo, Roshana Thambyrajah, Valérie Kouskoff, and Muhammad Zaki Hidayatullah Fadlullah. These collaborations have appeared across multiple publications.

Their research has been published predominantly in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Reports, SSRN Electronic Journal, and Blood. The distribution indicates a presence in both preprint and peer-reviewed journals relevant to biomedical and molecular sciences.

Main topics explored in their work include:

  • Zebrafish Biomedical Research Applications
  • Acute Myeloid Leukemia Research
  • Epigenetics and DNA Methylation
  • Immune Cell Function and Interaction
  • Prostate Cancer Treatment and Research
  • Hematopoietic Stem Cell Transplantation
  • T-cell and B-cell Immunology

Best Publications

  • The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage.

    Christophe Lancrin;Patrycja Sroczynska;Catherine Stephenson;Terence D Allen

  • Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation

    Hans Jörg Fehling;Georges Lacaud;Atsushi Kubo;Marion Kennedy

  • Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro.

    Georges Lacaud;Lia Gore;Marion Kennedy;Valerie Kouskoff

  • Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development

    John E. Pimanda;Katrin Ottersbach;Kathy Knezevic;Sarah Kinston

  • Leptin Stimulates Fetal and Adult Erythroid and Myeloid Development

    Adel A. Mikhail;Eric X Beck;Alan Shafer;Bruce Barut

  • Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

    Debbie K. Goode;Nadine Obier;M.S. Vijayabaskar;Michael Lie-A-Ling

  • Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation.

    Valerie Kouskoff;Georges Lacaud;Staci Schwantz;Hans Jöerg Fehling

  • The stepwise specification of embryonic stem cells to hematopoietic fate is driven by sequential exposure to Bmp4, activin A, bFGF and VEGF

    Stella Pearson;Patrycja Sroczynska;Georges Lacaud;Valerie Kouskoff

  • GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

    Roshana Thambyrajah;Milena Mazan;Milena Mazan;Rahima Patel;Victoria Moignard

  • Development of the hematopoietic system in the mouse

    Gordon Keller;Georges Lacaud;Scott Robertson

  • RUNX transcription factors: orchestrators of development

    Renaud Mevel;Julia E. Draper;Michael Lie-a-Ling;Valerie Kouskoff

  • RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

    Monika Lichtinger;Richard Ingram;Rebecca Hannah;Dorothee Müller

  • GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

    Christophe Lancrin;Milena Mazan;Monika Stefanska;Rahima Patel

  • Antigens Varying in Affinity for the B Cell Receptor Induce Differential B Lymphocyte Responses

    Valerie Kouskoff;Sara Famiglietti;Georges Lacaud;Paul Lang

  • Direct Reprogramming of Murine Fibroblasts to Hematopoietic Progenitor Cells

    Kiran Batta;Magdalena Florkowska;Valerie Kouskoff;Georges Lacaud

  • The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis

    Patrycja Sroczynska;Christophe Lancrin;Valerie Kouskoff;Georges Lacaud

  • B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.

    Valerie Kouskoff;Georges Lacaud;Georges Lacaud;Kathryn Pape;Marc Retter

  • Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis.

    Georges Lacaud;Valerie Kouskoff

  • Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

    Maarten Hoogenkamp;Monika Lichtinger;Hanna Krysinska;Christophe Lancrin

  • Origin of blood cells and HSC production in the embryo.

    Guilherme Costa;Valerie Kouskoff;Georges Lacaud

Frequent Co-Authors

Valerie Kouskoff
Valerie Kouskoff University of Manchester
Constanze Bonifer
Constanze Bonifer University of Birmingham
Berthold Göttgens
Berthold Göttgens University of Cambridge
Gordon Keller
Gordon Keller University of Toronto
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Karen Blyth
Karen Blyth University of Glasgow
David Nemazee
David Nemazee Scripps Research Institute
Tarik Möröy
Tarik Möröy University of Montreal
David Tannahill
David Tannahill University of Cambridge
Aravind Vijayaraghavan
Aravind Vijayaraghavan University of Manchester

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