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Molecular Biology

D-Index
58
Citations
9715
World Ranking
2112
National Ranking
50

Overview

Tim Thomas is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their work primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a strong focus also in Medicine. They have published extensively across several subfields, including Molecular Biology, Genetics, Cancer Research, Hematology, and Pulmonary and Respiratory Medicine.

The scientist's research topics are concentrated on Genomics and Chromatin Dynamics, Epigenetics and DNA Methylation, Genetics and Neurodevelopmental Disorders, Cancer Genomics and Diagnostics, Hematopoietic Stem Cell Transplantation, Genomic Variations and Chromosomal Abnormalities, and Acute Myeloid Leukemia Research.

Their frequent publishing venues indicate broad engagement with the biomedical research community, including multiple papers in Gastroenterology, Development, Nature Reviews Urology, bioRxiv (Cold Spring Harbor Laboratory), and Nature Communications.

Tim Thomas has collaborated frequently with a core group of co-authors:

  • Anne K. Voss
  • Gordon K. Smyth
  • Alexandra L. Garnham
  • Maria Bergamasco
  • Stephen Wilcox

Representative recent papers authored or co-authored by Tim Thomas showcase a focus on histone acetyltransferases, chromatin modification, and stem cell biology:

  • The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal, 2021, Blood
  • Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer, 2023, Cell Chemical Biology
  • Reference compounds for characterizing cellular injury in high-content cellular morphology assays, 2023, Nature Communications
  • Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest, 2022, Cell Death and Disease
  • Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7, 2023, Cell Reports

Best Publications

  • Purification of a pluripotent neural stem cell from the adult mouse brain

    Rodney L. Rietze;Helen Valcanis;Gordon F. Brooker;Tim Thomas

  • Mice lacking HSP90beta fail to develop a placental labyrinth.

    Anne K. Voss;Tim Thomas;Peter Gruss

  • Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

    Jonathan B. Baell;Jonathan B. Baell;David Leaver;Stefan J. Hermans;Gemma L. Kelly;Gemma L. Kelly

  • IAPs limit activation of RIP kinases by TNF receptor 1 during development

    Maryline Moulin;Holly Anderton;Holly Anderton;Anne K Voss;Anne K Voss;Tim Thomas;Tim Thomas

  • Whole-Exome-Sequencing Identifies Mutations in Histone Acetyltransferase Gene KAT6B in Individuals with the Say-Barber-Biesecker Variant of Ohdo Syndrome

    Jill Clayton-Smith;James O'Sullivan;Sarah Daly;Sanjeev Bhaskar

  • Mof (MYST1 or KAT8) Is Essential for Progression of Embryonic Development Past the Blastocyst Stage and Required for Normal Chromatin Architecture

    Tim Thomas;Mathew P. Dixon;Andrew J. Kueh;Andrew J. Kueh;Anne K. Voss;Anne K. Voss

  • Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells

    Tim Thomas;Lynn M. Corcoran;Raffi Gugasyan;Mathew P. Dixon

  • HBO1 Is Required for H3K14 Acetylation and Normal Transcriptional Activity during Embryonic Development

    Andrew J. Kueh;Mathew P. Dixon;Anne K. Voss;Anne K. Voss;Tim Thomas;Tim Thomas

  • Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.

    Stephen Bek Ngie Ting;Tomasz Wilanowski;Alana Auden;Mark A Hall

  • The Acute Phase Response in the Rodenta

    Gerhard Schreiber;Anna Tsykin;Angela R. Aldred;Timothy Thomas

  • Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity

    Anne K. Voss;Caitlin Collin;Mathew P. Dixon;Tim Thomas;Tim Thomas

  • Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.

    Dörthe M Katschinski;Lu Le;Susann G Schindler;Tim Thomas

  • Gene expression in regenerating and acute-phase rat liver.

    Julie Milland;Anna Tsykin;Tim Thomas;Angela R. Aldred

  • HBO1 is required for the maintenance of leukaemia stem cells.

    Laura MacPherson;Laura MacPherson;Juliana Anokye;Miriam M. Yeung;Enid Y.N. Lam;Enid Y.N. Lam

  • Querkopf, a MYST family histone acetyltransferase, is required for normal cerebral cortex development

    T. Thomas;A. K. Voss;K. Chowdhury;P. Gruss

  • Mutations in a Novel Gene, NHS, Cause the Pleiotropic Effects of Nance-Horan Syndrome, Including Severe Congenital Cataract, Dental Anomalies, and Mental Retardation

    Kathryn P. Burdon;Kathryn P. Burdon;James D. McKay;Michèle M. Sale;Michèle M. Sale;Isabelle M. Russell-Eggitt

  • MYST family histone acetyltransferases take center stage in stem cells and development

    Anne K. Voss;Tim Thomas;Tim Thomas

  • Structure and expression of the rat transthyretin (prealbumin) gene.

    W P Fung;T Thomas;P W Dickson;A R Aldred

  • ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

    Samir Taoudi;Thomas Bee;Adrienne Hilton;Kathy Knezevic

  • The transcriptional coactivator Querkopf controls adult neurogenesis.

    Tobias D. Merson;Mathew P. Dixon;Caitlin Collin;Rodney L. Rietze;Rodney L. Rietze

Frequent Co-Authors

Anne K. Voss
Anne K. Voss Walter and Eliza Hall Institute of Medical Research
Gordon K. Smyth
Gordon K. Smyth Walter and Eliza Hall Institute of Medical Research
Gerhard Schreiber
Gerhard Schreiber University of Melbourne
Peter Gruss
Peter Gruss Okinawa Institute of Science and Technology
Jonathan B. Baell
Jonathan B. Baell Monash University
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Hamish S. Scott
Hamish S. Scott University of Adelaide
Perry F. Bartlett
Perry F. Bartlett University of Queensland
Jozef Gecz
Jozef Gecz University of Adelaide

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