World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
62
Citations
10821
World Ranking
1867
National Ranking
150

Overview

Constanze Bonifer is affiliated with the University of Birmingham in the United Kingdom. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also in Medicine. Within these fields, they have contributed extensively to subfields such as Molecular Biology, Hematology, Cell Biology, Genetics, and Public Health, Environmental and Occupational Health.

Their main research topics include Acute Myeloid Leukemia Research, Protein Degradation and Inhibitors, Epigenetics and DNA Methylation, Genomics and Chromatin Dynamics, Chronic Myeloid Leukemia Treatments, Zebrafish Biomedical Research Applications, and Acute Lymphoblastic Leukemia research.

Constanze Bonifer has collaborated frequently with a group of co-authors, including Peter Keane, Peter N. Cockerill, Sophie G. Kellaway, Salam A. Assi, and Olaf Heidenreich, with each having co-authored multiple papers.

Their research has appeared in several publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Experimental Hematology
  • Nature Communications
  • Blood
  • Cell Reports

Among recent papers, notable titles include:

  • "Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia," published in Blood in 2022
  • "Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells," published in Nature Biotechnology in 2024
  • "RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia," published in Nature Communications in 2021
  • "Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells," published in Cell Reports in 2020
  • "The transcriptional regulation of normal and malignant blood cell development," published in FEBS Journal in 2021

Best Publications

  • Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

    Constanze Bonifer;M. Vidal;Frank Grosveld;A.E. Sippel

  • Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

    Björn Lamprecht;Korden Walter;Stephan Kreher;Stephan Kreher;Raman Kumar

  • Localization of cyclooxygenase-2 in human sporadic colorectal adenomas.

    Keith S. Chapple;Elizabeth J. Cartwright;Gillian Hawcroft;Alison Tisbury

  • Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

    Jason Piper;Markus C. Elze;Pierre Cauchy;Peter N. Cockerill

  • Stepwise Activation of Enhancer and Promoter Regions of the B Cell Commitment Gene Pax5 in Early Lymphopoiesis

    Thorsten Decker;Marina Pasca di Magliano;Shane McManus;Qiong Sun

  • Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.

    Debbie K. Goode;Nadine Obier;M.S. Vijayabaskar;Michael Lie-A-Ling

  • The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken

    Kimberley Bruce;Fiona A. Myers;Evangelia Mantouvalou;Pascal Lefevre

  • Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

    A Ptasinska;S A Assi;D Mannari;S R James

  • PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element

    Alexander K. Ebralidze;Florence C. Guibal;Ulrich Steidl;Pu Zhang

  • RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

    Monika Lichtinger;Richard Ingram;Rebecca Hannah;Dorothee Müller

  • Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice.

    M A Hull;J K Booth;A Tisbury;N Scott

  • GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

    Christophe Lancrin;Milena Mazan;Monika Stefanska;Rahima Patel

  • The LPS-induced transcriptional upregulation of the chicken lysozyme locus involves CTCF eviction and noncoding RNA transcription.

    Pascal Lefevre;James Witham;Claire E. Lacroix;Peter N. Cockerill

  • Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts

    Hartmut Geiger;Stefanie Sick;Constanze Bonifer;Albrecht M Müller

  • Subtype-specific regulatory network rewiring in acute myeloid leukemia

    Salam A. Assi;Maria Rosaria Imperato;Daniel J. L. Coleman;Anna Pickin

  • The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease.

    Leigh O'Connor;Jane Gilmour;Constanze Bonifer

  • Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells

    Hiromi Tagoh;Roy Himes;Deborah Clarke;Pieter J.M. Leenen

  • Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci

    Constanze Bonifer;Andreas Hecht;Harald Saueressig;Diana M. Winter

  • Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

    Mathias Leddin;Chiara Perrod;Maarten Hoogenkamp;Saeed Ghani

  • Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression

    Joanna Kontaraki;Hsiu-Hua Chen;Arthur Riggs;Constanze Bonifer

Frequent Co-Authors

Peter N. Cockerill
Peter N. Cockerill University of Birmingham
Daniel G. Tenen
Daniel G. Tenen National University of Singapore
Georges Lacaud
Georges Lacaud University of Manchester
Albrecht E. Sippel
Albrecht E. Sippel University of Freiburg
Valerie Kouskoff
Valerie Kouskoff University of Manchester
Andrew G. Elefanty
Andrew G. Elefanty University of Melbourne
Berthold Göttgens
Berthold Göttgens University of Cambridge
Arthur D. Riggs
Arthur D. Riggs City Of Hope National Medical Center
Edouard G. Stanley
Edouard G. Stanley University of Melbourne
Ruud Delwel
Ruud Delwel Erasmus MC

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