World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
14983
World Ranking
6441
National Ranking
3006

Overview

Frans A. Kuypers is affiliated with UCSF Benioff Children's Hospital in the United States. Their research spans multiple fields, focusing primarily on medicine and biochemistry, genetics, and molecular biology. Kuypers has contributed to understanding the molecular and physiological aspects of hematology and related disorders, often intersecting with pediatric health.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Kuypers has substantial work in several subfields such as:

  • Genetics
  • Molecular Biology
  • Hematology
  • Physiology
  • Pediatrics, Perinatology and Child Health

The principal topics covered in Kuypers' research are diverse, with a strong focus on blood and cellular function. These topics include:

  • Hemoglobinopathies and Related Disorders
  • Erythrocyte Function and Pathophysiology
  • Peroxisome Proliferator-Activated Receptors
  • Iron Metabolism and Disorders
  • Blood groups and transfusion
  • Metabolism and Genetic Disorders
  • Malaria Research and Control

Frequently collaborating with other researchers, Kuypers has coauthored multiple papers with the following individuals:

  • Sandra Larkin
  • Eric Soupène
  • Elliott Vichinsky
  • Maria Ribadeneira
  • Santosh L. Saraf

Kuypers' publications have appeared in several scientific venues, indicative of a broad engagement in research dissemination. The most common journals include:

  • Blood
  • PLoS ONE
  • Experimental Biology and Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Complementary Therapies in Medicine

Significant recent papers authored or coauthored by Kuypers comprise:

  • The diversity of ACBD proteins - From lipid binding to protein modulators and organelle tethers, 2020, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • Hyperinflammation, apoptosis, and organ damage, 2022, Experimental Biology and Medicine
  • Common host variation drives malaria parasite fitness in healthy human red cells, 2021, eLife
  • Secretory phospholipase A2 in SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C), 2021, Experimental Biology and Medicine
  • Blood draw site and analytic device influence hemoglobin measurements, 2022, PLoS ONE

Best Publications

  • Mammalian long-chain acyl-CoA synthetases.

    Eric Soupene;Frans A. Kuypers

  • Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly Asian descent

    Sylvia T. Singer;Vivian Wu;Robert Mignacca;Frans A. Kuypers

  • Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).

    S. R. Meshnick;Ying-Zi Yang;V. Lima;F. Kuypers

  • Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?

    Claudia R. Morris;Sidney M. Morris;Ward Hagar;Jane Van Warmerdam

  • Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V

    Frans A. Kuypers;Rachel A. Lewis;Mandy Hua;Mary Ann Schott

  • Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid.

    Christine C. Winterbourn;Jeroen J.M. van den Berg;Esther Roitman;Frans A. Kuypers

  • Decreased arginine bioavailability and increased serum arginase activity in asthma.

    Claudia R. Morris;Mirjana Poljakovic;Lisa Lavrisha;Lorenzo Machado

  • Erythrocyte defense against hydrogen peroxide: preeminent importance of catalase.

    Mark D. Scott;Bertram H. Lubin;Lin Zuo;Frans A. Kuypers

  • Whole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease

    Nigel S. Key;Arne Slungaard;Luke Dandelet;Stephen C. Nelson

  • Membrane Phospholipid Asymmetry in Human Thalassemia

    Frans A. Kuypers;Jie Yuan;Rachel A. Lewis;L. Michael Snyder

  • Kinetics and site specificity of hydroperoxide-induced oxidative damage in red blood cells.

    Jeroen J.M. van den Berg;Jos A.F. Op den Kamp;Bertram H. Lubin;Ben Roelofsen

  • Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome

    Claudia R. Morris;Frans A. Kuypers;Sandra Larkin;Elliott P. Vichinsky

  • Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease

    Claudia R. Morris;Jung H. Suh;Ward Hagar;Sandra Larkin

  • Parinaric acid as a sensitive fluorescent probe for the determination of lipid peroxidation

    F.A. Kuypers;J.J.M. van den Berg;C. Schalkwijk;B. Roelofsen

  • Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.

    Douglas G. Mashek;Karin E. Bornfeldt;Rosalind A. Coleman;Johannes Berger

  • Atherosclerosis and plasma and liver lipids in nine inbred strains of mice.

    Patsy M. Nishina;Jiajin Wang;Wendy Toyofuku;Frans A. Kuypers

  • STRUCTURAL AND FUNCTIONAL CONSEQUENCES OF ANTIGENIC MODULATION OF RED BLOOD CELLS WITH METHOXYPOLY (ETHYLENE GLYCOL)

    Kari L. Murad;Kathleen L. Mahany;Carlo Brugnara;Frans A. Kuypers

  • VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis

    Betty Y Y Tam;Kevin Wei;John S Rudge;Jana Hoffman

  • Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia.

    Kitty de Jong;Renee K. Emerson;James Butler;Jacob Bastacky

  • Pulmonary hypertension in thalassemia: association with platelet activation and hypercoagulable state.

    Sylvia T. Singer;Frans A. Kuypers;Lori Styles;Elliott P. Vichinsky

Frequent Co-Authors

Elliott Vichinsky
Elliott Vichinsky University of California, San Francisco
Bruce N. Ames
Bruce N. Ames University of California, Berkeley
Ben Roelofsen
Ben Roelofsen Utrecht University
Philippe Leboulch
Philippe Leboulch Brigham and Women's Hospital
Nancy F. Olivieri
Nancy F. Olivieri University of Toronto
Albert P. Pisano
Albert P. Pisano University of California, San Diego
Carlo Brugnara
Carlo Brugnara Boston Children's Hospital
Young-Ho Cho
Young-Ho Cho Korea Advanced Institute of Science and Technology
Patrick G. Gallagher
Patrick G. Gallagher Yale University
Ellis J. Neufeld
Ellis J. Neufeld Boston Children's Hospital

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