World's Best Scientists 2026 revealed!
Award Badge
Best Scientists
2025
Award Badge
Biology and Biochemistry
USA
2023

D-Index & Metrics

Best Scientists

D-Index
187
Citations
184288
World Ranking
463
National Ranking
304

Biology and Biochemistry

D-Index
185
Citations
185414
World Ranking
59
National Ranking
50

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2013 - Fellow of the American Academy of Microbiology Genetics and Molecular Biology
  • 2001 - ASM Lifetime Achievement Award, American Society for Microbiology
  • 1998 - US President's National Medal of Science "For changing the direction of basic and applied research on mutation, cancer and aging by devising a simple, inexpensive test for environmental and natural mutagens, by identifying causes and effects of oxidative DNA damage, and by translating these findings into intelligible public policy recommendations on diet and cancer risk for the American people.", Presented by President William Jefferson Clinton in a White House (East Room) ceremony on Tuesday, April 27, 1999
  • 1997 - Japan Prize for the contribution to establishment of fundamental concept on causes of cancer.
  • 1983 - Canada Gairdner International Award
  • 1983 - Charles S. Mott Prize, General Motors Cancer Research Foundation
  • 1980 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1972 - Member of the National Academy of Sciences
  • 1970 - Fellow of the American Academy of Arts and Sciences

Overview

Bruce N. Ames was affiliated with the University of California, Berkeley in the United States. Their research contributions spanned the fields of immunology, microbiology, and medicine, with a focus on immunology and oncology subfields.

The scientist's recent publications included the paper titled XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies published in 2023 in the journal Molecular Cancer Therapeutics.

Frequent coauthors in their work included:

  • Ekta Patel
  • Natalia V. Malkova
  • David Crowe
  • Magali Pederzoli-Ribeil
  • Damiano Fantini

The primary venues for publication were focused mainly on Molecular Cancer Therapeutics.

The main topics addressed in their scientific work were:

  • Cytokine Signaling Pathways and Interactions
  • Interferon and Immune Responses
  • Immunotherapy and Immune Responses

Their recognized scientific areas of study included:

  • Immunology and Microbiology
  • Medicine

Within immunology and related disciplines, their efforts involved understanding cellular signaling and immune mechanisms relevant to cancer treatment and immune modulation.

Bruce N. Ames received numerous awards acknowledging their scientific contributions, including:

  • Fellow of the American Academy of Microbiology (2013) for work in genetics and molecular biology
  • ASM Lifetime Achievement Award from the American Society for Microbiology (2001)
  • US President's National Medal of Science (1998), presented for developing a simple test for environmental mutagens and for contributions linking oxidative DNA damage to cancer and aging
  • Japan Prize (1997) for establishing fundamental concepts on causes of cancer
  • Charles S. Mott Prize from the General Motors Cancer Research Foundation (1983)
  • Canada Gairdner International Award (1983)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1980)
  • Member of the National Academy of Sciences (1972)
  • Fellow of the American Academy of Arts and Sciences (1970)

Best Publications

  • Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

    Bruce N. Ames;Joyce McCann;Edith Yamasaki

  • Oxidants, antioxidants, and the degenerative diseases of aging

    Bruce N. Ames;Mark K. Shigenaga;Tory M. Hagen

  • A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

    Robert G. Martin;Bruce N. Ames

  • Dietary carcinogens and anticarcinogens Oxygen radicals and degenerative diseases

    Bruce N. Ames

  • ASSAY OF INORGANIC PHOSPHATE, TOTAL PHOSPHATE AND PHOSPHATASE

    Bruce N. Ames

  • Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals

    Joyce McCann;Edmund Choi;Edith Yamasaki;Bruce N. Ames

  • Bilirubin is an antioxidant of possible physiological importance

    Roland Stocker;Yorihiro Yamamoto;Antony F. McDonagh;Alexander N. Glazer

  • Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

    Bruce N. Ames;Richard Cathcart;Elizabeth Schwiers;Paul Hochstein

  • Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

    Bruce N. Ames;William E. Durston;Edith Yamasaki;Frank D. Lee

  • The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid.

    Bruce N. Ames;Donald T. Dubin

  • Oxidative damage and mitochondrial decay in aging

    Mark K. Shigenaga;Tory M. Hagen;Bruce N. Ames

  • Oxygen Radicals and Human Disease

    Carroll E. Cross;Barry Halliwell;Edward T. Borish;William A. Pryor

  • Ascorbate is an outstanding antioxidant in human blood plasma.

    Balz Frei;Laura England;Bruce N. Ames

  • Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

    Christoph Richter;Jeen-Woo Park;Bruce N. Ames

  • An improved bacterial test system for the detection and classification of mutagens and carcinogens

    Bruce N. Ames;Frank D. Lee;William E. Durston

  • The causes and prevention of cancer.

    Bruce Ames;Lois Gold;Walter C.:: ea eef a fc b fa b:: Willett

  • Antioxidant defenses and lipid peroxidation in human blood plasma.

    Balz Frei;Roland Stocker;Bruce N. Ames

  • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage

    Benjamin C. Blount;Matthew M. Mack;Carol M. Wehr;James T. MacGregor

  • Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.

    Joyce McCann;Neil E. Spingarn;Joan Kobori;Bruce N. Ames

  • Positive Control of a Regulon for Defenses against Oxidative Stress and Some Heat-Shock Proteins in Salmonella typhimurium

    Michael F. Christman;Robin W. Morgan;Fredric S. Jacobson;Bruce N. Ames

Frequent Co-Authors

Jiankang Liu
Jiankang Liu Xi'an Jiaotong University
Elliott Vichinsky
Elliott Vichinsky University of California, San Francisco
Frans A. Kuypers
Frans A. Kuypers UCSF Benioff Children's Hospital
Tory M. Hagen
Tory M. Hagen Oregon State University
Gisela Storz
Gisela Storz National Institutes of Health
Balz Frei
Balz Frei Boston University
George Perry
George Perry The University of Texas at San Antonio
Roland Stocker
Roland Stocker The Heart Research Institute
David E. Levin
David E. Levin Boston University
Monica Hollstein
Monica Hollstein University of Leeds

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring online degree options in Biology and Biochemistry can open doors to varied healthcare careers. For those interested in supporting doctors and patients directly, medical assistant courses online are a flexible starting point. These programs can be completed quickly and often include financial aid options.

Many students choose to further their qualifications after becoming a medical assistant. The cma to lpn pathway enables professionals to advance into Licensed Practical Nursing roles without starting over, making career progression both efficient and affordable.

If your goal is to dive deep into biosciences, an accelerated bachelor's degree in biology online is ideal for motivated learners. These condensed programs help you achieve a four-year degree in a shorter time, perfect for those eager to enter research, education, or advanced study fields.

For aspiring nurses, an online asn program provides a direct pathway into registered nursing. These degrees blend scientific knowledge with hands-on skills and are widely respected in the medical community.

Best Scientists Citing Bruce N. Ames