World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
92
Citations
31506
World Ranking
2210
National Ranking
131

Overview

Hiroshi Kasai is affiliated with the University of Occupational and Environmental Health Japan in Japan. Their research primarily lies within the field of Medicine, with a focus on Nutrition and Dietetics, Molecular Biology, Biochemistry, Pathology and Forensic Medicine, and Food Science. The body of work spans topics related to DNA Repair Mechanisms, Alcohol Consumption and Health Effects, Biochemical Analysis and Sensing Techniques, Nutritional Studies and Diet, Nutrition, Health and Food Behavior, Antioxidant Activity and Oxidative Stress, and Cytomegalovirus and herpesvirus research.

The scientist has contributed to several publications, including:

  • Diurnal and day-to-day variation of urinary oxidative stress marker 8-hydroxy-2'-deoxyguanosine, 2020, Journal of Clinical Biochemistry and Nutrition
  • The Association between Oxidative Balance Score and Urinary Levels of 8-Hydroxydeoxyguanosine among Japanese Adults, 2023, Nutrients
  • Free radical-mediated acetaldehyde formation by model reactions of dietary components: effects of meat, wine, cooking oil and coffee, 2021, Genes and Environment
  • New Plausible Mechanism for Gastric and Colorectal Carcinogenesis: Free Radical-Mediated Acetaldehyde Generation in a Heme/Myoglobin-Linoleate-Ethanol Mixture, 2021, ACS Omega
  • Formation of the mutagenic DNA lesion 1,N2-ethenoguanine induced by heated cooking oil and identification of causative agents, 2023, Genes and Environment

The frequent co-authors collaborating with Hiroshi Kasai include:

  • Kazuaki Kawai
  • Yun-Shan Li
  • Yuya Kawasaki
  • Yuka Hasebe
  • Kenji Kashiwagi

Their research articles have been published repeatedly in several venues, notably:

  • Genes and Environment
  • Nutrients
  • Journal of Clinical Biochemistry and Nutrition
  • ACS Omega
  • Zenodo (CERN European Organization for Nuclear Research)

The work of Hiroshi Kasai demonstrates a multidisciplinary approach incorporating biochemical and molecular biological techniques. Central to their studies are mechanisms of oxidative stress and DNA damage, especially as they relate to environmental and dietary factors such as alcohol consumption, cooking oil, and meat. This includes investigating molecular pathways leading to carcinogenesis and identifying mutagenic lesions formed under specific conditions.

Key topics addressed in their research include the dynamics of urinary oxidative stress markers, the relationship between antioxidant balance and DNA damage in humans, and the biochemical formation of harmful compounds derived from food processing and consumption. This research contributes to the understanding of health risks associated with diet and environmental exposures, with implications for nutrition and preventive medicine.

Best Publications

  • Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

    Hiroshi Kasai

  • Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

    H. Kasai;P.F. Crain;Y. Kuchino;S. Nishimura

  • Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

    Hiroshi Kasai;Susumu Nishimura

  • Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

    Y Kuchino;F Mori;H Kasai;H Inoue

  • 8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

    J Tchou;H Kasai;S Shibutani;M H Chung

  • Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.

    IB Weinstein;AM Jeffrey;KW Jennette;SH Blobstein

  • Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients

    Hideya Kodama;Raizo Yamaguchi;Jun Fukuda;Hiroshi Kasai

  • Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

    Takashi Kohno;Kazuya Shinmura;Kazuya Shinmura;Masahiko Tosaka;Masachika Tani

  • Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.

    Hiroshi Kasai;Susumu Nishimura;Yuji Kurokawa;Yuzo Hayashi

  • Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa

    Seung-Chul Baik;Hee-Shang Youn;Myung-Hee Chung;Woo-Kon Lee

  • Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction

    Hiroshi Kasai;Ziro Yamaizumi;Maurice Berger;Jean Cadet

  • Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis.

    Ryuya Shimoda;Makoto Nagashima;Michiie Sakamoto;Naohito Yamaguchi

  • Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung

    Shinya Asami;Hideo Manabe;Jun Miyake;Yosuke Tsurudome

  • Increase of a Type of Oxidative DNA Damage, 8-Hydroxyguanine, and Its Repair Activity in Human Leukocytes by Cigarette Smoking

    Shinya Asami;Takeshi Hirano;Raizo Yamaguchi;Yoshiaki Tomioka

  • BENZO(A)PYRENE-NUCLEIC ACID DERIVATIVE FOUND IN VIVO- STRUCTURE OF A BENZO(A)PYRENETETRAHYDRODIOL EPOXIDE-GUANOSINE ADDUCT

    A. M. Jeffrey;K. W. Jennette;S. H. Blobstein;I. B. Weinstein

  • Formation of 8-hydroxydeoxyguanosine in liver DNA of rats following long-term exposure to a peroxisome proliferator.

    H. Kasai;Y. Okada;S. Nishimura;M. S. Rao

  • Action of chlorogenic acid in vegetables and fruits as an inhibitor of 8-hydroxydeoxyguanosine formation in vitro and in a rat carcinogenesis model.

    H Kasai;S Fukada;Z Yamaizumi;S Sugie

  • Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine.

    H Kasai;Z Oashi;F Harada;S Nishimura

  • The Oxidized Forms of dATP Are Substrates for the Human MutT Homologue, the hMTH1 Protein

    Katsuyoshi Fujikawa;Hiroyuki Kamiya;Hiroyuki Yakushiji;Yoshimitsu Fujii

  • Life style and urinary 8-hydroxydeoxyguanosine, a marker of oxidative dna damage: effects of exercise, working conditions, meat intake, body mass index, and smoking.

    Hiroshi Kasai;Naoko Iwamoto-Tanaka;Toshiaki Miyamoto;Kiyoshi Kawanami

Frequent Co-Authors

Susumu Nishimura
Susumu Nishimura University of Tsukuba
Hiroyuki Kamiya
Hiroyuki Kamiya Hiroshima University
Tetsuya Mizoue
Tetsuya Mizoue Kyushu University
Koji Nakanishi
Koji Nakanishi Columbia University
Tatsuo Miyazawa
Tatsuo Miyazawa University of Tokyo
Minako Nagao
Minako Nagao National Cancer Research Institute, UK
Keiji Wakabayashi
Keiji Wakabayashi University of Shizuoka
Hideyoshi Harashima
Hideyoshi Harashima Hokkaido University
Yoshiyuki Kuchino
Yoshiyuki Kuchino National Cancer Research Institute, UK

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