D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 87 Citations 24,879 300 World Ranking 1827 National Ranking 106

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • DNA
  • Gene

Hiroshi Kasai mainly investigates Biochemistry, DNA, DNA damage, 8-Hydroxy-2'-deoxyguanosine and Internal medicine. As part of his studies on Biochemistry, he frequently links adjacent subjects like Molecular biology. His work deals with themes such as Carcinogenesis, Escherichia coli, Stereochemistry and Hydroxylation, which intersect with DNA.

His DNA damage study combines topics from a wide range of disciplines, such as Yield, Mass spectrum, Strain and Nuclear chemistry. His 8-Hydroxy-2'-deoxyguanosine research is multidisciplinary, incorporating perspectives in 8-Oxo-2'-deoxyguanosine, Urine, Lung, Creatinine and Deoxyguanosine. The study incorporates disciplines such as Endocrinology, Depression, Surgery and Center for Epidemiologic Studies Depression Scale in addition to Internal medicine.

His most cited work include:

  • 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. (1557 citations)
  • Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis (939 citations)
  • Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair (838 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Biochemistry, DNA, Molecular biology, Oxidative stress and DNA damage. His DNA research is multidisciplinary, incorporating elements of Carcinogenesis, Gene, Guanine, Stereochemistry and Radical. His Molecular biology research integrates issues from DNA glycosylase, DNA repair, Mutation, Mutant and DNA polymerase.

His Oxidative stress research includes elements of Urinary system, Urine and Carcinogen. DNA damage is frequently linked to Reactive oxygen species in his study. His biological study spans a wide range of topics, including Surgery and Oxidative dna damage.

He most often published in these fields:

  • Biochemistry (35.80%)
  • DNA (32.10%)
  • Molecular biology (24.38%)

What were the highlights of his more recent work (between 2005-2021)?

  • Oxidative stress (23.77%)
  • Internal medicine (17.90%)
  • Biochemistry (35.80%)

In recent papers he was focusing on the following fields of study:

Hiroshi Kasai mainly focuses on Oxidative stress, Internal medicine, Biochemistry, Urinary system and Urine. The Oxidative stress study combines topics in areas such as Cancer, DNA damage, Reactive oxygen species and Toxicity, Genotoxicity. His Internal medicine study combines topics in areas such as Endocrinology and Pathology.

Biochemistry is represented through his DNA, Lipid peroxidation, Carcinogenesis, DNA methylation and Carcinogen research. He has researched DNA in several fields, including Molecular biology, Oxidative phosphorylation and Gene. His study in Urine is interdisciplinary in nature, drawing from both 8-Hydroxy-2'-deoxyguanosine, Chromatography, Deoxyguanosine and Food science.

Between 2005 and 2021, his most popular works were:

  • Prospective study of 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and the risk of lung cancer. (136 citations)
  • Metal nanoparticle-induced micronuclei and oxidative DNA damage in mice (96 citations)
  • Human and Methodological Sources of Variability in the Measurement of Urinary 8-Oxo-7,8-dihydro-2 '-deoxyguanosine (95 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Gene

His main research concerns Oxidative stress, Biochemistry, Urine, Urinary system and DNA damage. His research on Oxidative stress is centered around Endocrinology and Internal medicine. In general Biochemistry, his work in DNA, Lipid peroxidation, Genomic library and Real-time polymerase chain reaction is often linked to Genomic organization linking many areas of study.

Hiroshi Kasai interconnects Carcinogenesis, In vitro, Radiochemistry and X ray irradiation in the investigation of issues within DNA. His DNA damage study integrates concerns from other disciplines, such as Molecular biology, Toxicology and Genotoxicity. His Molecular biology study incorporates themes from DNA repair and DNA polymerase.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.

Keith C. Cheng;David S. Cahill;Hiroshi Kasai;Susumu Nishimura.
Journal of Biological Chemistry (1992)

2590 Citations

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

Hiroshi Kasai.
Mutation Research-reviews in Mutation Research (1997)

1480 Citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

H. Kasai;P.F. Crain;Y. Kuchino;S. Nishimura.
Carcinogenesis (1986)

1338 Citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

Hiroshi Kasai;Susumu Nishimura.
Nucleic Acids Research (1984)

1306 Citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

Y Kuchino;F Mori;H Kasai;H Inoue.
Nature (1987)

1126 Citations

Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.

IB Weinstein;AM Jeffrey;KW Jennette;SH Blobstein.
Science (1976)

725 Citations

Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients

Hideya Kodama;Raizo Yamaguchi;Jun Fukuda;Hiroshi Kasai.
Fertility and Sterility (1997)

662 Citations

Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

Takashi Kohno;Kazuya Shinmura;Kazuya Shinmura;Masahiko Tosaka;Masachika Tani.
Oncogene (1998)

574 Citations

Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.

Hiroshi Kasai;Susumu Nishimura;Yuji Kurokawa;Yuzo Hayashi.
Carcinogenesis (1987)

488 Citations

Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa

Seung-Chul Baik;Hee-Shang Youn;Myung-Hee Chung;Woo-Kon Lee.
Cancer Research (1996)

477 Citations

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