Hiroshi Kasai mainly investigates Biochemistry, DNA, DNA damage, 8-Hydroxy-2'-deoxyguanosine and Internal medicine. As part of his studies on Biochemistry, he frequently links adjacent subjects like Molecular biology. His work deals with themes such as Carcinogenesis, Escherichia coli, Stereochemistry and Hydroxylation, which intersect with DNA.
His DNA damage study combines topics from a wide range of disciplines, such as Yield, Mass spectrum, Strain and Nuclear chemistry. His 8-Hydroxy-2'-deoxyguanosine research is multidisciplinary, incorporating perspectives in 8-Oxo-2'-deoxyguanosine, Urine, Lung, Creatinine and Deoxyguanosine. The study incorporates disciplines such as Endocrinology, Depression, Surgery and Center for Epidemiologic Studies Depression Scale in addition to Internal medicine.
His primary areas of investigation include Biochemistry, DNA, Molecular biology, Oxidative stress and DNA damage. His DNA research is multidisciplinary, incorporating elements of Carcinogenesis, Gene, Guanine, Stereochemistry and Radical. His Molecular biology research integrates issues from DNA glycosylase, DNA repair, Mutation, Mutant and DNA polymerase.
His Oxidative stress research includes elements of Urinary system, Urine and Carcinogen. DNA damage is frequently linked to Reactive oxygen species in his study. His biological study spans a wide range of topics, including Surgery and Oxidative dna damage.
Hiroshi Kasai mainly focuses on Oxidative stress, Internal medicine, Biochemistry, Urinary system and Urine. The Oxidative stress study combines topics in areas such as Cancer, DNA damage, Reactive oxygen species and Toxicity, Genotoxicity. His Internal medicine study combines topics in areas such as Endocrinology and Pathology.
Biochemistry is represented through his DNA, Lipid peroxidation, Carcinogenesis, DNA methylation and Carcinogen research. He has researched DNA in several fields, including Molecular biology, Oxidative phosphorylation and Gene. His study in Urine is interdisciplinary in nature, drawing from both 8-Hydroxy-2'-deoxyguanosine, Chromatography, Deoxyguanosine and Food science.
His main research concerns Oxidative stress, Biochemistry, Urine, Urinary system and DNA damage. His research on Oxidative stress is centered around Endocrinology and Internal medicine. In general Biochemistry, his work in DNA, Lipid peroxidation, Genomic library and Real-time polymerase chain reaction is often linked to Genomic organization linking many areas of study.
Hiroshi Kasai interconnects Carcinogenesis, In vitro, Radiochemistry and X ray irradiation in the investigation of issues within DNA. His DNA damage study integrates concerns from other disciplines, such as Molecular biology, Toxicology and Genotoxicity. His Molecular biology study incorporates themes from DNA repair and DNA polymerase.
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8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions.
Keith C. Cheng;David S. Cahill;Hiroshi Kasai;Susumu Nishimura.
Journal of Biological Chemistry (1992)
Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
Mutation Research-reviews in Mutation Research (1997)
Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair
H. Kasai;P.F. Crain;Y. Kuchino;S. Nishimura.
Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents
Hiroshi Kasai;Susumu Nishimura.
Nucleic Acids Research (1984)
Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues
Y Kuchino;F Mori;H Kasai;H Inoue.
Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo.
IB Weinstein;AM Jeffrey;KW Jennette;SH Blobstein.
Increased oxidative deoxyribonucleic acid damage in the spermatozoa of infertile male patients
Hideya Kodama;Raizo Yamaguchi;Jun Fukuda;Hiroshi Kasai.
Fertility and Sterility (1997)
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA
Takashi Kohno;Kazuya Shinmura;Kazuya Shinmura;Masahiko Tosaka;Masachika Tani.
Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA.
Hiroshi Kasai;Susumu Nishimura;Yuji Kurokawa;Yuzo Hayashi.
Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa
Seung-Chul Baik;Hee-Shang Youn;Myung-Hee Chung;Woo-Kon Lee.
Cancer Research (1996)
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