World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
39342
World Ranking
2916
National Ranking
1494

Medicine

D-Index
85
Citations
39159
World Ranking
14392
National Ranking
7278

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Geoffrey L. Greene is affiliated with the University of Chicago in the United States and primarily focuses on research within Biochemistry, Genetics, and Molecular Biology. Their scholarly output includes 78 publications in this main field, with significant contributions to Molecular Biology, Genetics, Oncology, Cancer Research, and Pulmonary and Respiratory Medicine.

The scientist has authored multiple papers on topics related to cancer biology and hormone effects, particularly in the context of breast cancer. Notable recent publications include:

  • Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis, 2021, Cell
  • Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer, 2021, Breast Cancer Research
  • The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor-Positive Breast Cancers, 2020, Molecular Cancer Research
  • Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells, 2022, eLife
  • A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice, 2021, Science Translational Medicine

Their research topics encompass a range of focus areas including:

  • Estrogen and related hormone effects
  • Advanced Breast Cancer Therapies
  • Computational Drug Discovery Methods
  • Atomic and Subatomic Physics Research
  • HER2/EGFR in Cancer Research
  • Nuclear Physics and Applications
  • Cytokine Signaling Pathways and Interactions

Frequent publication venues reflect a consistent presence in journals that span cancer research and biology:

  • Cancer Research (14 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • arXiv (Cornell University) (5 publications)
  • Journal of the Endocrine Society (5 publications)
  • Breast Cancer Research (3 publications)

Collaboration plays a role in their work, with the most frequent coauthors being:

  • Sean W. Fanning
  • Muriel Lainé
  • Rosemary J. Huggins
  • David J. Hosfield
  • N. Fomin

Among awards received, Geoffrey L. Greene was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2016.

Best Publications

  • Molecular basis of agonism and antagonism in the oestrogen receptor.

    Andrzej M. Brzozowski;Ashley C. W. Pike;Zbigniew Dauter;Roderick E. Hubbard

  • The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

    Andrew K. Shiau;Danielle Barstad;Paula M. Loria;Lin Cheng

  • Monoclonal antibodies localize oestrogen receptor in the nuclei of target cells.

    W. J. King;G. L. Greene

  • Sequence and expression of human estrogen receptor complementary DNA

    Geoffrey L. Greene;Paul Gilna;Michael Waterfield;Andrew Baker

  • Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells.

    Mahnaz Razandi;Ali Pedram;Geoffrey L. Greene;Ellis R. Levin;Ellis R. Levin

  • ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

    Weiyi Toy;Yang Shen;Helen Won;Bradley Green

  • Estrogen receptor pathways to AP-1.

    Peter J. Kushner;David A. Agard;Geoffrey L. Greene;Thomas S. Scanlan

  • Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells

    Barry S. Komm;Christopher M. Terpening;David J. Benz;Kimberlie A. Graeme

  • Cloning of the human estrogen receptor cDNA.

    P Walter;S Green;G Greene;A Krust

  • Immunohistochemical Analysis of Human Uterine Estrogen and Progesterone Receptors Throughout the Menstrual Cycle

    Bruce A. Lessey;Allen P. Killam;Deborah A. Metzger;A. F. Haney

  • Monoclonal antibodies to human estrogen receptor.

    G L Greene;C Nolan;J P Engler;E V Jensen

  • Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.

    Greene Me;Blumberg B;McBride Ow;Yi Hf

  • Immunochemical studies of estrogen receptors.

    Geoffrey L. Greene;Nancy B. Sobel;W.J. King;Elwood V. Jensen

  • Androgen receptor localization in different cell types of the adult rat prostate.

    Gail S. Prins;Lynn Birch;Geoffrey L. Greene

  • Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.

    Andrew K. Shiau;Danielle Barstad;James T. Radek;Marvin J. Meyers

  • Plasma membrane estrogen receptors exist and functions as dimers.

    Mahnaz Razandi;Ali Pedram;Istvan Merchenthaler;Geoffrey L. Greene

  • Overcoming mutation-based resistance to antiandrogens with rational drug design

    Minna D Balbas;Michael J Evans;David J Hosfield;John Wongvipat

  • Cloning of the human oestrogen receptor cDNA.

    Stephen Green;Philippe Walter;Geoffrey Greene;Andrée Krust

  • Regulation of estrogen receptor messenger ribonucleic acid and protein levels in human breast cancer cell lines by sex steroid hormones, their antagonists, and growth factors.

    Linnea D. Read;Geoffrey L. Greene;Benita S. Katzenellenbogen

  • Estrogen Receptor (α and β) Expression in the Excurrent Ducts of the Adult Male Rat Reproductive Tract

    Rex A. Hess;Daniel H. Gist;David Bunick;Dennis B. Lubahn

Frequent Co-Authors

John A. Katzenellenbogen
John A. Katzenellenbogen University of Illinois at Urbana-Champaign
Benita S. Katzenellenbogen
Benita S. Katzenellenbogen University of Illinois at Urbana-Champaign
Michael F. Press
Michael F. Press University of Southern California
Sarat Chandarlapaty
Sarat Chandarlapaty Memorial Sloan Kettering Cancer Center
Kathryn E. Carlson
Kathryn E. Carlson University of Illinois at Urbana-Champaign
Emad Tajkhorshid
Emad Tajkhorshid University of Illinois at Urbana-Champaign
Michael F. Clarke
Michael F. Clarke Stanford University
Bert W. O'Malley
Bert W. O'Malley Baylor College of Medicine
Charles M. Perou
Charles M. Perou University of North Carolina at Chapel Hill
Suzanne A. W. Fuqua
Suzanne A. W. Fuqua Baylor College of Medicine

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