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Biology and Biochemistry

D-Index
132
Citations
79176
World Ranking
378
National Ranking
249

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Valerian E. Kagan is affiliated with the University of Pittsburgh in the United States and has a substantial body of research in biochemistry, genetics, and molecular biology, with a focus on medicine. Their work spans various subfields including molecular biology, pulmonary and respiratory medicine, immunology, cancer research, and nutrition and dietetics.

The scientist has contributed extensively to several research topics, notably:

  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Mitochondrial function and pathology
  • Immune cells in cancer
  • Cancer, lipids, and metabolism
  • Trace elements in health
  • ATP synthase and ATPases research

Kagan's recent published papers include:

  • "Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo," 2022, Nature Metabolism
  • "Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death," 2020, Nature Chemical Biology
  • "Ferroptosis of tumour neutrophils causes immune suppression in cancer," 2022, Nature
  • "Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal," 2021, Nature Chemical Biology
  • "Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis," 2020, Cell Chemical Biology

The scientist's frequent co-authors include:

  • Yulia Y. Tyurina
  • Hülya Bayır
  • Vladimir A. Tyurin
  • Alexandr A. Kapralov
  • Tamil S. Anthonymuthu

Kagan has published frequently in notable scientific venues such as:

  • Redox Biology
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • JCI Insight
  • Free Radical Biology and Medicine

Awards include being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2012.

Best Publications

  • Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

    Brent R. Stockwell;José Pedro Friedmann Angeli;Hülya Bayir;Ashley I. Bush

  • Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

    Jose Pedro Friedmann Angeli;Manuela Schneider;Bettina Proneth;Yulia Y. Tyurina

  • ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

    Sebastian Doll;Bettina Proneth;Yulia Y Tyurina;Elena Panzilius

  • Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

    Valerian E Kagan;Gaowei Mao;Feng Qu;Jose Pedro Friedmann Angeli

  • Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

    Anna A. Shvedova;Elena R. Kisin;Robert Mercer;Ashley R. Murray

  • Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

    Valerian E Kagan;Vladimir A Tyurin;Jianfei Jiang;Yulia Y Tyurina

  • Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

    Charleen T. Chu;Jing Ji;Ruben K. Dagda;Jian Fei Jiang

  • PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

    Sally E. Wenzel;Yulia Y. Tyurina;Jinming Zhao;Claudette M. St. Croix

  • Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation

    Valerian E. Kagan;Nagarjun V. Konduru;Weihong Feng;Brett L. Allen

  • Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol.

    Elena Serbinova;Valerian Kagan;Derick Han;Lester Packer

  • The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart.

    Meerson Fz;Meerson Fz;Kagan Ve;Kagan Ve;Kozlov YuP;Kozlov YuP;Belkina Lm;Belkina Lm

  • Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

    Anna A. Shvedova;Elena R. Kisin;Ashley R. Murray;Victor J Johnson

  • Lipid accumulation and dendritic cell dysfunction in cancer

    Donna L. Herber;Wei Cao;Yulia Nefedova;Sergey V. Novitskiy

  • FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.

    Michael M. Gaschler;Alexander A. Andia;Hengrui Liu;Joleen M. Csuka

  • Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron.

    V.E. Kagan;Y.Y. Tyurina;V.A. Tyurin;N.V. Konduru

  • The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis.

    Maik Hüttemann;Petr Pecina;Matthew Rainbolt;Thomas H. Sanderson

  • Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals.

    Valerian E. Kagan;Anna Shvedova;Elena Serbinova;Shabi Khan

  • Fatty acid transport protein 2 reprograms neutrophils in cancer

    Filippo Veglia;Vladimir A. Tyurin;Maria Blasi;Alessandra De Leo

  • Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

    Anna A. Shvedova;Antonio Pietroiusti;Bengt Fadeel;Bengt Fadeel;Valerian E. Kagan

  • Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling.

    Valerian Kagan;Elena Serbinova;Elena Serbinova;Lester Packer;Lester Packer

Frequent Co-Authors

Yulia Y. Tyurina
Yulia Y. Tyurina University of Pittsburgh
Vladimir A. Tyurin
Vladimir A. Tyurin University of Pittsburgh
Hülya Bayır
Hülya Bayır University of Pittsburgh
Anna A. Shvedova
Anna A. Shvedova National Institute for Occupational Safety and Health
Joel S. Greenberger
Joel S. Greenberger University of Pittsburgh
Andrew A. Amoscato
Andrew A. Amoscato University of Pittsburgh
Patrick M. Kochanek
Patrick M. Kochanek University of Pittsburgh
Michael W. Epperly
Michael W. Epperly University of Pittsburgh
Peter Wipf
Peter Wipf University of Pittsburgh
Judith Klein-Seetharaman
Judith Klein-Seetharaman Arizona State University

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