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Biology and Biochemistry

D-Index
65
Citations
13289
World Ranking
9271
National Ranking
4096

Overview

Michael W. Epperly is affiliated with the University of Pittsburgh in the United States. Their work spans multiple domains within medicine and biochemistry, genetics, and molecular biology, with a significant emphasis on radiology, nuclear medicine, and imaging.

Their research covers a range of topics including:

  • Effects of Radiation Exposure
  • Cancer Cells and Metastasis
  • Mesenchymal stem cell research
  • Ferroptosis and cancer prognosis
  • Telomeres, Telomerase, and Senescence
  • Cancer Research and Treatments
  • Ultrasound and Hyperthermia Applications

Michael W. Epperly's recent publications illustrate their focus on radiation biology and therapeutic interventions. Selected papers include:

  • Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development (2020), published in EBioMedicine
  • Space Radiation Protection Countermeasures in Microgravity and Planetary Exploration (2021), published in Life
  • Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis (2020), published in Radiation Research
  • Interferon β drives intestinal regeneration after radiation (2021), published in Science Advances
  • P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis (2022), published in JCI Insight

Frequent coauthors of this researcher include:

  • Joel S. Greenberger
  • Renee Fisher
  • Wen-Chi Hou
  • Donna Shields
  • Amitava Mukherjee

Their articles have appeared recurrently in journals such as:

  • In Vivo
  • International Journal of Radiation Oncology*Biology*Physics
  • Radiation Research
  • International Journal of Molecular Sciences
  • Plastic & Reconstructive Surgery Global Open

Michael W. Epperly's main areas of study include medicine, particularly with specialization in radiology, nuclear medicine, and imaging, complemented by related fields within molecular biology and oncology. Their work frequently addresses mechanisms underlying radiation exposure effects and interventions in cancer biology and treatment.

Best Publications

  • Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts

    Shuanhu Zhou;Joel S. Greenberger;Michael W. Epperly;Julie P. Goff

  • Microneedle array delivered recombinant coronavirus vaccines: Immunogenicity and rapid translational development.

    Eun Kim;Geza Erdos;Shaohua Huang;Thomas W. Kenniston

  • Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis.

    Michael W. Epperly;Hongliang Guo;Joan E. Gretton;Joel S. Greenberger

  • Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential.

    Baohong Cao;Bo Zheng;Ron J. Jankowski;Shigemi Kimura

  • Human In vivo Radiation-Induced Biomarkers Gene Expression Changes in Radiotherapy Patients

    Sally A. Amundson;Marcy B. Grace;Christopher B. McLeland;Michael W. Epperly

  • Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes

    Roberto Gomez-Casal;Chitralekha Bhattacharya;Nandita Ganesh;Lisa A. Bailey

  • PUMA Regulates Intestinal Progenitor Cell Radiosensitivity and Gastrointestinal Syndrome

    Wei Qiu;Eleanor B. Carson-Walter;Hongtao Liu;Michael Epperly

  • Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy.

    M. Epperly;J. Bray;S. Kraeger;R. Zwacka

  • Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage.

    Michael W. Epperly;Joan E. Gretton;Christine A. Sikora;Mia Jefferson

  • Effect of Radiation on Interstitial Fluid Pressure and Oxygenation in a Human Tumor Xenograft

    Cynthia A. Znati;Maury Rosenstein;Yves Boucher;Michael W. Epperly

  • Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane.

    Michael W. Epperly;Christine A. Sikora;Stacy J. DeFilippi;Joan A. Gretton

  • Intratracheal injection of adenovirus containing the human MNSOD transgene protects athymic nude mice from irradiation-induced organizing alveolitis

    Michael W Epperly;Jenifer A Bray;Stephen Krager;Luann M Berry

  • A mitochondrial pathway for biosynthesis of lipid mediators.

    Yulia Y. Tyurina;Samuel M. Poloyac;Vladimir A. Tyurin;Alexander A. Kapralov

  • FANCD2 protects against bone marrow injury from ferroptosis.

    Xinxin Song;Yangchun Xie;Rui Kang;Wen Hou

  • Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis.

    Michael W Epperly;Elizabeth L Travis;Christine Sikora;Joel S Greenberger

  • Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

    M W Epperly;S Defilippi;C Sikora;J Gretton

  • Modulation of Radiation-Induced Cytokine Elevation Associated with Esophagitis and Esophageal Stricture by Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Gene Therapy

    Michael W. Epperly;Joan A. Gretton;Stacy J. DeFilippi;Christine A. Sikora

  • Redox Gene Therapy Protects Human IB-3 Lung Epithelial Cells Against Ionizing Radiation-Induced Apoptosis

    Ralf M. Zwacka;Lorita Dudus;Michael W. Epperly;Joel S. Greenberger

  • Prevention of Radiation-Induced Oral Cavity Mucositis by Plasmid/Liposome Delivery of the Human Manganese Superoxide Dismutase (SOD2) Transgene

    Hongliang Guo;Jose A. Seixas-Silva;Michael W. Epperly;Joan E. Gretton

  • Ex vivo gene transfer using adenovirus-mediated full-length dystrophin delivery to dystrophic muscles.

    S. S. Floyd;P. R. Clemens;M. R. Ontell;S. Kochanek

Frequent Co-Authors

Joel S. Greenberger
Joel S. Greenberger University of Pittsburgh
Peter Wipf
Peter Wipf University of Pittsburgh
Valerian E. Kagan
Valerian E. Kagan University of Pittsburgh
Song Li
Song Li University of Pittsburgh
Hülya Bayır
Hülya Bayır University of Pittsburgh
Yulia Y. Tyurina
Yulia Y. Tyurina University of Pittsburgh
Vladimir A. Tyurin
Vladimir A. Tyurin University of Pittsburgh
Andrew A. Amoscato
Andrew A. Amoscato University of Pittsburgh
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
James D. Luketich
James D. Luketich University of Pittsburgh

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