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Penelope J. Hallett

Penelope J. Hallett

D-Index & Metrics

Neuroscience

D-Index
37
Citations
6171
World Ranking
8760
National Ranking
3713

Overview

Penelope J. Hallett is affiliated with Harvard University in the United States and has focused their research primarily on medicine, biochemistry, genetics, molecular biology, and neuroscience. Their work extensively covers subfields such as neurology, physiology, molecular biology, cellular and molecular neuroscience, and cell biology.

The main topics Penelope J. Hallett has contributed to include:

  • Lysosomal Storage Disorders Research
  • Parkinson's Disease Mechanisms and Treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cellular transport and secretion
  • Alzheimer's disease research and treatments
  • Cholesterol and Lipid Metabolism
  • Nuclear Receptors and Signaling

Among recent publications are:

  • Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance, 2020, Proceedings of the National Academy of Sciences
  • Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients, 2020, Frontiers in Cellular Neuroscience
  • Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice, 2020, Molecular Therapy - Nucleic Acids
  • Glycosphingolipid metabolism and its role in ageing and Parkinson's disease, 2021, Glycoconjugate Journal
  • Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2, 2021, Molecular Brain

Penelope J. Hallett collaborates frequently with several researchers, most notably Ole Isacson, with whom they have coauthored sixteen papers. Other frequent coauthors include Ria Thomas and Kyle J. Connolly, each with four shared publications, as well as Oeystein Roed Brekk and David A. Priestman, each with three joint works.

Their work has appeared in various scientific venues, with multiple publications in Scientific Reports and bioRxiv (Cold Spring Harbor Laboratory), and additional papers published in Proceedings of the National Academy of Sciences, Frontiers in Cellular Neuroscience, and Glycoconjugate Journal.

Best Publications

  • Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

    Gunnar Hargus;Oliver Cooper;Michela Deleidi;Adam Levy

  • Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years

    Ivar Mendez;Angel Viñuela;Arnar Astradsson;Karim Mukhida

  • Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

    Penelope J. Hallett;Michela Deleidi;Arnar Astradsson;Gaynor A. Smith

  • Rationale for and use of NMDA receptor antagonists in Parkinson's disease.

    Penelope J Hallett;David G Standaert

  • Dopamine D1 Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking

    Penelope J. Hallett;Robert Spoelgen;Bradley T. Hyman;David G. Standaert

  • Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons†

    Maria Sundberg;Helle Bogetofte;Tristan Lawson;Johan Jansson

  • Progressive decline of glucocerebrosidase in aging and Parkinson's disease

    Emily M. Rocha;Gaynor A. Smith;Eric Park;Hongmei Cao

  • Alterations of striatal NMDA receptor subunits associated with the development of dyskinesia in the MPTP-lesioned primate model of Parkinson's disease.

    Penelope J. Hallett;A.W. Dunah;Paula Ravenscroft;Shaobo Zhou

  • Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients

    Penelope J. Hallett;Oliver Cooper;Damaso Sadi;Harold Robertson

  • Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

    Mylene Huebecker;Elizabeth B. Moloney;Aarnoud C. van der Spoel;David A. Priestman

  • Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

    Emily M. Rocha;Gaynor A. Smith;Eric Park;Hongmei Cao

  • Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.

    Emily M. Rocha;Gaynor A. Smith;Eric Park;Hongmei Cao

  • Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

    Penelope J. Hallett;Jesse R. McLean;Andrew Kartunen;J. William Langston

  • Biochemical fractionation of brain tissue for studies of receptor distribution and trafficking.

    Penelope J. Hallett;Tiffany L. Collins;David G. Standaert;Anthone W. Dunah

  • The Toll-Like Receptor-3 Agonist Polyinosinic:Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration

    Michela Deleidi;Penelope J. Hallett;James B. Koprich;Chee-Yeun Chung

  • Striatal histone modifications in models of levodopa-induced dyskinesia

    Anthony P. Nicholas;Anthony P. Nicholas;Farah D. Lubin;Penelope J. Hallett;Padmapriya Vattem

  • The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.

    Elizabeth B. Moloney;Alyssa Moskites;Eliza J. Ferrari;Ole Isacson

  • Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection

    Jesse R. McLean;Gaynor A. Smith;Emily M. Rocha;Melissa A. Hayes

  • Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease

    Gaynor A. Smith;Emily M. Rocha;Jesse R. McLean;Melissa A. Hayes

  • Inhibition of the Dopamine D1 Receptor Signaling by PSD-95

    Jingping Zhang;Angel Vinuela;Mark H. Neely;Penelope J. Hallett

Frequent Co-Authors

Ole Isacson
Ole Isacson Harvard University
Anna-Liisa Brownell
Anna-Liisa Brownell Harvard University
Seth G. N. Grant
Seth G. N. Grant University of Edinburgh
James B. Koprich
James B. Koprich Fudan University
Bradley T. Hyman
Bradley T. Hyman Harvard University
Tatyana D. Sotnikova
Tatyana D. Sotnikova Italian Institute of Technology
J. David Sweatt
J. David Sweatt University of Alabama at Birmingham
Alain Dagher
Alain Dagher Montreal Neurological Institute and Hospital
Bruce G. Jenkins
Bruce G. Jenkins Harvard University
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania

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