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Anna-Liisa Brownell

Anna-Liisa Brownell

D-Index & Metrics

Neuroscience

D-Index
36
Citations
7509
World Ranking
8921
National Ranking
3774

Overview

Anna-Liisa Brownell is affiliated with Harvard University in the United States. Their research spans multiple areas within the broader fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Neuroscience. They have contributed notably to subfields including Molecular Biology, Radiology, Nuclear Medicine and Imaging, Cellular and Molecular Neuroscience, Genetics, and Cognitive Neuroscience.

Brownell's work covers significant topics such as Neuroscience and Neuropharmacology Research, Chemical Synthesis and Analysis, Receptor Mechanisms and Signaling, Medical Imaging Techniques and Applications, Genetics and Neurodevelopmental Disorders, Radiopharmaceutical Chemistry and Applications, and Epigenetics and DNA Methylation.

Frequent publication venues include the Journal of Medicinal Chemistry, Cancer Gene Therapy, bioRxiv (Cold Spring Harbor Laboratory), Scientific Reports, and RSC Advances. Their publication record demonstrates a focus on both chemical and biological aspects of medical imaging and neuropharmacology.

Recent papers authored or coauthored by Brownell include:

  • In vivo imaging of mGlu5 receptor expression in humans with Fragile X Syndrome towards development of a potential biomarker, 2021, Scientific Reports
  • A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes, 2020, RSC Advances
  • Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2, 2021, Molecular Imaging and Biology
  • Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2, 2020, Journal of Medicinal Chemistry
  • Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain, 2020, Journal of Medicinal Chemistry

Collaborations play a notable role in Brownell's body of work. Frequent co-authors include:

  • Georges El Fakhri (12 collaborations)
  • Gengyang Yuan (11 collaborations)
  • Sepideh Afshar (10 collaborations)
  • Sung-Hyun Moon (9 collaborations)
  • Marc D. Normandin (7 collaborations)

Best Publications

  • Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

    Lars M. Björklund;Rosario Sánchez-Pernaute;Sangmi Chung;Therese Andersson;Therese Andersson

  • Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease.

    Kevin St. P. McNaught;Daniel P. Perl;Anna-Liisa Brownell;C. Warren Olanow

  • Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

    F. Cicchetti;A. L. Brownell;K. Williams;Y. I. Chen

  • Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

    Penelope J. Hallett;Michela Deleidi;Arnar Astradsson;Gaynor A. Smith

  • Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data

    Yin Ching I. Chen;Wendy R. Galpern;Anna‐Liisa Brownell;Russell T. Matthews

  • Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease

    Rosario Sánchez-Pernaute;Rosario Sánchez-Pernaute;Andrew Ferree;Andrew Ferree;Oliver Jamie Cooper;Oliver Jamie Cooper;Meixiang Yu

  • Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites, and positron emission tomography imaging.

    P. C. Meltzer;A. Y. Liang;A. L. Brownell;D. R. Elmaleh

  • Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism

    P Hantraye;A L Brownell;D Elmaleh;R D Spealman

  • Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease

    L.H. Burns;P. Pakzaban;P. Pakzaban;T.W. Deacon;T.W. Deacon;A.-L. Brownell

  • Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET.

    Tuong V. Nguyen;Anna-Liisa Brownell;Yin-Ching Iris Chen;Elijahu Livni

  • Diagnosis of acute herpes simplex encephalitis by brain perfusion single photon emission computed tomography.

    Jyrki Launes;Lena Lindroth;Kristian Liewendahl;Päivi Nikkinen

  • Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease

    Anna-Liisa Brownell;Anna-Liisa Brownell;Bruce G. Jenkins;David R. Elmaleh;Terrence W. Deacon

  • Mapping dopamine function in primates using pharmacologic magnetic resonance imaging.

    Bruce G. Jenkins;Rosario Sanchez-Pernaute;Anna-Liisa Brownell;Yin-Ching Iris Chen

  • Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging

    Y. Iris Chen;Aaron M. Cypess;Aaron M. Cypess;Christina A. Sass;Anna-Liisa Brownell

  • Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5

    Ji-Quan Wang;Werner Tueckmantel;Aijun Zhu;Daniela Pellegrino

  • Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.

    Y I Chen;A L Brownell;W Galpern;O Isacson

  • Cerebral PET imaging and histological evidence of transglutaminase inhibitor cystamine induced neuroprotection in transgenic R6/2 mouse model of Huntington's disease

    Xukui Wang;Aparajita Sarkar;Francesca Cicchetti;Meixiang Max Yu

  • In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants

    Anna-Liisa Brownell;Eli Livni;Wendy R. Galpern;Ole Isacson

  • A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload.

    Michael J. Raher;Helene B. Thibault;Emmanuel S. Buys;Darshini Kuruppu

  • Imaging of Activated Natural Killer Cells in Mice by Positron Emission Tomography: Preferential Uptake in Tumors

    Robert J. Melder;Anna Liisa Brownell;Timothy M. Shoup;Gordon L. Brownell

Frequent Co-Authors

Ole Isacson
Ole Isacson Harvard University
Bruce G. Jenkins
Bruce G. Jenkins Harvard University
Francesca Cicchetti
Francesca Cicchetti Université Laval
Bruce R. Rosen
Bruce R. Rosen Harvard University
Bertha K. Madras
Bertha K. Madras Harvard University
M. Flint Beal
M. Flint Beal Cornell University
Ullrich Wüllner
Ullrich Wüllner University Hospital Bonn
Thomas Witzel
Thomas Witzel Harvard University
Penelope J. Hallett
Penelope J. Hallett Harvard University
Kazue Takahashi
Kazue Takahashi Harvard University

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