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Neuroscience

D-Index
118
Citations
49985
World Ranking
409
National Ranking
243

Overview

D. James Surmeier is affiliated with Northwestern University in the United States and has contributed extensively to the fields of neuroscience as well as biochemistry, genetics, and molecular biology. Their research primarily focuses on cellular and molecular neuroscience, with significant engagement in molecular biology, pharmacology, cognitive neuroscience, and biomaterials.

Their main research topics include neuroscience and neuropharmacology, mitochondrial function and pathology, genetic neurodegenerative diseases, neurotransmitter receptor influence on behavior, phosphodiesterase function and regulation, cholinesterase and neurodegenerative diseases, and ion channel regulation and function.

Surmeier's recent publications demonstrate a broad scope within these themes. Notable papers include:

  • CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors, 2021, Neurobiology of Disease
  • Ca2+-dependent phosphodiesterase 1 regulates the plasticity of striatal spiny projection neuron glutamatergic synapses, 2024, Cell Reports
  • Cell- and state-specific plasticity of striatal glutamatergic synapses is critical to the expression of levodopa-induced dyskinesia, 2024, bioRxiv (Cold Spring Harbor Laboratory)
  • Presynaptic Mu Opioid Receptors Suppress the Functional Connectivity of Ventral Tegmental Area Dopaminergic Neurons with Aversion-Related Brain Regions, 2025, Journal of Neuroscience
  • CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors, 2021, Zenodo (CERN European Organization for Nuclear Research)

Surmeier has frequently collaborated with several researchers including Shenyu Zhai, Jill R. Crittenden, Magdalena Sauvage, Takashi Kitsukawa, and Eric Burguière. Their work has been published across various specialized venues such as:

  • Neurobiology of Disease
  • Cell Reports
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuroscience
  • Zenodo (CERN European Organization for Nuclear Research)

The combination of Surmeier's focus on neurotransmitter systems, synaptic plasticity, and molecular mechanisms reflects a multidisciplinary approach to understanding neurological function and pathology. Their contributions span experimental neuroscience, molecular biology, and neuropharmacology, emphasizing mechanisms underlying neurodegenerative diseases, synaptic regulation, and cellular signaling pathways.

Best Publications

  • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

    Sonja Kriks;Jae Won Shim;Jinghua Piao;Yosif M. Ganat

  • Modulation of Striatal Projection Systems by Dopamine

    Charles R. Gerfen;D. James Surmeier

  • D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

    D. James Surmeier;Jun Ding;Michelle Day;Zhongfeng Wang

  • Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

    Weixing Shen;Marc Flajolet;Paul Greengard;D. James Surmeier

  • A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

    Myriam Heiman;Anne Schaefer;Shiaoching Gong;Jayms D. Peterson

  • Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumbens.

    Saleem M. Nicola;D. James Surmeier;Robert C. Malenka

  • Selective neuronal vulnerability in Parkinson disease.

    D. James Surmeier;José A. Obeso;José A. Obeso;Glenda M. Halliday;Glenda M. Halliday

  • ‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease

    C. Savio Chan;Jaime N. Guzman;Ema Ilijic;Jeff N. Mercer

  • Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

    Jaime N. Guzman;Javier Sanchez-Padilla;David Wokosin;Jyothisri Kondapalli

  • Negative feedback control of neuronal activity by microglia

    Ana Badimon;Hayley J. Strasburger;Pinar Ayata;Xinhong Chen

  • Coordinated Expression of Dopamine Receptors in Neostriatal Medium Spiny Neurons

    D. James Surmeier;Wen Jie Song;Zhen Yan

  • Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

    J.A. Obeso;M. Stamelou;M. Stamelou;C.G. Goetz;W. Poewe

  • Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

    Lena F. Burbulla;Lena F. Burbulla;Pingping Song;Joseph R. Mazzulli;Joseph R. Mazzulli;Enrico Zampese

  • Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

    Max B. Kelz;Jingshan Chen;William A. Carlezon;William A. Carlezon;Kim Whisler

  • Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease models

    Michelle Day;Zhongfeng Wang;Jun Ding;Xinhai An

  • Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons

    D.James Surmeier;Jose Bargas;Hugh C Hemmings;Hugh C Hemmings;Angus C Nairn

  • DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

    A. A. Fienberg;N. Hiroi;Paul G Mermelstein;W. J. Song

  • D2 Dopamine Receptors in Striatal Medium Spiny Neurons Reduce L-Type Ca2+ Currents and Excitability via a Novel PLCβ1–IP3–Calcineurin-Signaling Cascade

    Salvador Hernández-López;Tatiana Tkatch;Enrique Perez-Garci;Elvira Galarraga

  • D1 Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+ Conductance

    Salvador Hernández-López;José Bargas;D. James Surmeier;Arturo Reyes

  • Dopaminergic Control of Corticostriatal Long-Term Synaptic Depression in Medium Spiny Neurons Is Mediated by Cholinergic Interneurons

    Zhongfeng Wang;Li Kai;Michelle Day;Jennifer Ronesi

Frequent Co-Authors

C. Savio Chan
C. Savio Chan Northwestern University
Tatiana Tkatch
Tatiana Tkatch Northwestern University
Paul Greengard
Paul Greengard Rockefeller University
Mark D. Bevan
Mark D. Bevan Northwestern University
Zhen Yan
Zhen Yan University at Buffalo, State University of New York
Peter Penzes
Peter Penzes Northwestern University
Glenda M. Halliday
Glenda M. Halliday University of Sydney
S.T. Kitai
S.T. Kitai University of Tennessee Health Science Center
M. Angela Cenci
M. Angela Cenci Lund University
Ilya Bezprozvanny
Ilya Bezprozvanny The University of Texas Southwestern Medical Center

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Related Online Degrees & Career Pathways

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