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Gregory Stephanopoulos

Gregory Stephanopoulos

D-Index & Metrics

Biology and Biochemistry

D-Index
126
Citations
67434
World Ranking
487
National Ranking
311

Research.com Recognitions

  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2003 - Member of the National Academy of Engineering For pioneering contributions in defining and advancing metabolic engineering and for leadership in incorporating biology into chemical engineering research and education.
  • 1992 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Gregory Stephanopoulos is affiliated with MIT in the United States and has contributed extensively to the field of biochemical and molecular biology research. Their primary research focus lies within Biochemistry, Genetics, and Molecular Biology, with a substantial number of publications in Molecular Biology, Biomedical Engineering, Cancer Research, Pharmacology, and Biotechnology subfields.

Their research topics cover a broad range of areas, including microbial metabolic engineering and bioproduction, plant biochemistry and biosynthesis, enzyme catalysis and immobilization, biofuel production and bioconversion, cancer, hypoxia and metabolism, metabolomics and mass spectrometry studies, and microbial natural products and biosynthesis.

They have contributed to numerous scientific publications, with frequent appearances in journals such as Metabolic Engineering, Trends in Biotechnology, Current Opinion in Biotechnology, bioRxiv (Cold Spring Harbor Laboratory), and Nature Communications.

  • Metabolic Engineering
  • Trends in Biotechnology
  • Current Opinion in Biotechnology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications

Among their recent papers are:

  • "Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica" (2022, Nature Communications)
  • "Enhancing isoprenoid synthesis in Yarrowia lipolytica by expressing the isopentenol utilization pathway and modulating intracellular hydrophobicity" (2020, Metabolic Engineering)
  • "Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica" (2021, Metabolic Engineering)
  • "Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers" (2020, Blood)
  • "Novel Strategies and Platforms for Industrial Isoprenoid Engineering" (2020, Trends in Biotechnology)

Several frequent co-authors have collaborated with this scientist, including Wentao Dong, Nian Liu, Kang Zhou, Matthew J. Pavlovich, and Rolf Van Der Sanden.

  • Wentao Dong
  • Nian Liu
  • Kang Zhou
  • Matthew J. Pavlovich
  • Rolf Van Der Sanden

Gregory Stephanopoulos has received various recognitions during their career. They were elected Fellow of the American Association for the Advancement of Science (AAAS) in 2005 and became a Member of the National Academy of Engineering in 2003 for pioneering contributions in defining and advancing metabolic engineering and for leadership in incorporating biology into chemical engineering research and education. Additionally, they are a Fellow of the Indian National Academy of Engineering (INAE), elected in 1992.

Best Publications

  • Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

    Parayil Kumaran Ajikumar;Wen-Hai Xiao;Keith E. J. Tyo;Yong Wang

  • Metabolic Engineering: Principles and Methodologies

    Gregory N. Stephanopoulos;Aristos A. Aristidou;Jens Nielsen

  • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

    Christian M. Metallo;Paulo A. Gameiro;Eric L. Bell;Katherine R. Mattaini

  • Engineering Cell Shape and Function

    Rahul Singhvi;Amit Kumar;Gabriel P. Lopez;Gregory N. Stephanopoulos

  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  • Tuning genetic control through promoter engineering

    Hal S Alper;Curt Fischer;Elke Nevoigt;Elke Nevoigt;Gregory Stephanopoulos

  • Engineering yeast transcription machinery for improved ethanol tolerance and production.

    Hal Alper;Joel Moxley;Elke Nevoigt;Elke Nevoigt;Gerald R. Fink

  • Challenges in Engineering Microbes for Biofuels Production

    Gregory Stephanopoulos

  • Metabolic fluxes and metabolic engineering.

    Gregory Stephanopoulos

  • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

    Dimitrios Anastasiou;Yimin Yu;William James Israelsen;Jian-Kang Jiang

  • Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

    Rushika M. Perera;Svetlana Stoykova;Brandon N. Nicolay;Kenneth N. Ross

  • Network rigidity and metabolic engineering in metabolite overproduction.

    Gregory Stephanopoulos;Joseph J. Vallino

  • A roadmap for interpreting 13 C metabolite labeling patterns from cells

    Joerg M. Buescher;Maciek R. Antoniewicz;Laszlo G. Boros;Shawn C Burgess

  • Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production.

    Mitchell Tai;Gregory Stephanopoulos

  • Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction.

    Joseph J. Vallino;Gregory Stephanopoulos

  • Distributing a metabolic pathway among a microbial consortium enhances production of natural products

    Kang Zhou;Kangjian Qiao;Steven Edgar;Gregory Stephanopoulos

  • The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

    Alfred Csibi;Sarah-Maria Fendt;Chenggang Li;George Poulogiannis

  • Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions

    Maciek R. Antoniewicz;Joanne K. Kelleher;Gregory Stephanopoulos

  • Device containing cytophilic islands that adhere cells separated by cytophobic regions

    Rahul Singhvi;Amit Kumar;George M. Whitesides;Donald E. Ingber

  • Identifying gene targets for the metabolic engineering of lycopene biosynthesis in Escherichia coli.

    Hal S Alper;Yong Su Jin;J. F. Moxley;G. Stephanopoulos

Frequent Co-Authors

Hal S. Alper
Hal S. Alper The University of Texas at Austin
Christian M. Metallo
Christian M. Metallo University of California, San Diego
Maciek R. Antoniewicz
Maciek R. Antoniewicz University of Delaware
Daniel I. C. Wang
Daniel I. C. Wang Chinese Academy of Tropical Agricultural Sciences
Martin L. Yarmush
Martin L. Yarmush Rutgers, The State University of New Jersey
Ka-Yiu San
Ka-Yiu San Rice University

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