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Hiroshi Shimizu

Hiroshi Shimizu

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
10677
World Ranking
14484
National Ranking
1022

Overview

Hiroshi Shimizu is affiliated with Osaka University in Japan, where their research focuses on the intersection of biochemistry, genetics, and molecular biology. Their scholarly work covers a breadth of topics primarily centered on microbial metabolic engineering and bioproduction, photosynthetic processes and mechanisms, and viral infectious diseases and gene expression in insects. Additional research areas include algal biology and biofuel production, photoreceptor and optogenetics studies, enzyme structure and function, and metabolomics with mass spectrometry applications.

Shimizu's publication record includes contributions to several well-regarded scientific journals. These frequent publication venues include:

  • Journal of Bioscience and Bioengineering
  • Metabolic Engineering
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Synthetic Biology
  • Metabolic Engineering Communications

Among recent papers are:

  • Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy, 2021, Hepatology
  • Soft-sensor development for monitoring the lysine fermentation process, 2021, Journal of Bioscience and Bioengineering
  • mfapy: An open-source Python package for 13C-based metabolic flux analysis, 2021, Metabolic Engineering Communications
  • Logistic Regression-Guided Identification of Cofactor Specificity-Contributing Residues in Enzyme with Sequence Datasets Partitioned by Catalytic Properties, 2022, ACS Synthetic Biology
  • Flux controlling technology for central carbon metabolism for efficient microbial bio-production, 2020, Current Opinion in Biotechnology

Collaborative efforts form an important part of Shimizu's research activities. Frequent coauthors include Yoshihiro Toya, Fumio Matsuda, Teppei Niide, Nobuyuki Okahashi, and Masakazu Toyoshima. These partnerships have contributed to advancing knowledge in molecular biology and metabolic engineering.

Shimizu's scientific contributions emphasize molecular biology, with 73 of their publications in this subfield alone, complemented by work in renewable energy, sustainability, cellular and molecular neuroscience, oncology, and materials chemistry.

Their exploration of microbial metabolic engineering and bioproduction remains a significant focus, with 46 publications addressing this area. Other noteworthy topics addressed include photosynthetic processes, viral infectious diseases and gene expression in insects, algal biology and biofuel production, photoreceptor and optogenetics research, enzyme structure and function, and metabolomics studies using mass spectrometry.

Best Publications

  • Comprehensive phenotypic analysis for identification of genes affecting growth under ethanol stress in Saccharomyces cerevisiae.

    Katsunori Yoshikawa;Tadamasa Tanaka;Chikara Furusawa;Keisuke Nagahisa

  • Identification of target genes conferring ethanol stress tolerance to Saccharomyces cerevisiae based on DNA microarray data analysis.

    Takashi Hirasawa;Katsunori Yoshikawa;Yuki Nakakura;Keisuke Nagahisa

  • Agarose for a bioartificial pancreas

    Hiroo Iwata;Tatsuya Takagi;Hiroshi Amemiya;Hiroshi Shimizu

  • Solar cell device

    Yukitsugu Akinobu;Oshi Hikosaka;Masao Ikushima;Hiroshi Inoue

  • Comprehensive phenotypic analysis of single-gene deletion and overexpression strains of Saccharomyces cerevisiae.

    Katsunori Yoshikawa;Tadamasa Tanaka;Yoshihiro Ida;Chikara Furusawa

  • Enhanced kefiran production by mixed culture of Lactobacillus kefiranofaciens and Saccharomyces cerevisiae.

    Benjamas Cheirsilp;Hiroshi Shimizu;Suteaki Shioya

  • Transcriptome analysis of parallel-evolved Escherichia coli strains under ethanol stress

    Takaaki Horinouchi;Kuniyasu Tamaoka;Chikara Furusawa;Naoaki Ono

  • Determining the angle of repose of sand under low-gravity conditions using discrete element method

    Hiroshi Nakashima;Yasuyuki Shioji;Taizo Kobayashi;Shigeru Aoki

  • Flux analysis and metabolomics for systematic metabolic engineering of microorganisms.

    Yoshihiro Toya;Hiroshi Shimizu

  • Nisin production by a mixed-culture system consisting of Lactococcus lactis and Kluyveromyces marxianus.

    Hiroshi Shimizu;Taiji Mizuguchi;Eiji Tanaka;Suteaki Shioya

  • Differential importance of trehalose accumulation in Saccharomyces cerevisiae in response to various environmental stresses

    Siraje Arif Mahmud;Takashi Hirasawa;Hiroshi Shimizu

  • Discrete element method analysis of single wheel performance for a small lunar rover on sloped terrain

    H. Nakashima;H. Fujii;A. Oida;M. Momozu

  • Beer Volatile Compounds and Their Application to Low-Malt Beer Fermentation

    Michiko Kobayashi;Hiroshi Shimizu;Suteaki Shioya

  • Development and experimental verification of a genome-scale metabolic model for Corynebacterium glutamicum

    Yohei Shinfuku;Natee Sorpitiporn;Masahiro Sono;Chikara Furusawa

  • Adaptation of Saccharomyces cerevisiae cells to high ethanol concentration and changes in fatty acid composition of membrane and cell size.

    Thai Nho Dinh;Keisuke Nagahisa;Takashi Hirasawa;Chikara Furusawa

  • Optimal production of glutathione by controlling the specific growth rate of yeast in fed-batch culture.

    Hiroshi Shimizu;Katshuiro Araki;Suteaki Shioya;Ken-ichi Suga

  • Day light quality affects the night-break response in the short-day plant chrysanthemum, suggesting differential phytochrome-mediated regulation of flowering.

    Yohei Higuchi;Katsuhiko Sumitomo;Atsushi Oda;Hiroshi Shimizu

  • Interactions between Lactobacillus kefiranofaciens and Saccharomyces cerevisiae in mixed culture for kefiran production

    Benjamas Cheirsilp;Benjamas Cheirsilp;Hirofumi Shoji;Hiroshi Shimizu;Sutekaki Shioya

  • Recent advances in amino acid production by microbial cells.

    Takashi Hirasawa;Hiroshi Shimizu

  • Effect of amino acids on glutathione production by Saccharomyces cerevisiae

    Catalino G. Alfafara;Akihisa Kanda;Toru Shioi;Hiroshi Shimizu

Frequent Co-Authors

Chikara Furusawa
Chikara Furusawa University of Tokyo
Fumio Matsuda
Fumio Matsuda Osaka University
Tetsuya Yomo
Tetsuya Yomo East China Normal University
Royal D. Heins
Royal D. Heins Michigan State University
Akihiko Kondo
Akihiko Kondo Kobe University
Takuya Nihira
Takuya Nihira Osaka University
Silvio Bicciato
Silvio Bicciato University of Modena and Reggio Emilia
Naoki Shinohara
Naoki Shinohara Kyoto University
Masahiro Murakami
Masahiro Murakami Kyoto University

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