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Molecular Biology

D-Index
52
Citations
10065
World Ranking
2434
National Ranking
1198

Overview

James Hagman is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology, with particular focus on molecular biology, immunology, oncology, pathology and forensic medicine, and cancer research.

Their work covers multiple main topics related to immunotherapy and immune responses, genomics and chromatin dynamics, mast cells and histamine, heat shock proteins research, protease and inhibitor mechanisms, cancer immunotherapy and biomarkers, and epigenetics and DNA methylation.

James Hagman has authored or co-authored several peer-reviewed research papers, contributing to various notable journals. Key publications include:

  • "GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers," 2021, Nature Communications
  • "EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene," 2021, Blood
  • "α1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages," 2022, The Journal of Immunology
  • "Mi-2β promotes immune evasion in melanoma by activating EZH2 methylation," 2024, Nature Communications
  • "Chromodomain helicase DNA-binding 4 (CHD4) regulates early B cell identity and V(D)J recombination*," 2021, Immunological Reviews

Frequent co-authors collaborating with James Hagman include Laura Harmacek, Brian P. O'Connor, Yapeng Li, Jun-Feng Gao, and Mohammad Kamran.

Their research has been published predominantly in the journals Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Blood, The Journal of Immunology, and Immunological Reviews.

Best Publications

  • Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

    Nikhil S. Joshi;Weiguo Cui;Anmol Chandele;Heung Kyu Lee

  • Ets transcription factors: nuclear effectors of the Ras–MAP-kinase signaling pathway

    Bohdan Wasylyk;James Hagman;Arthur Gutierrez-Hartmann

  • A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

    Yin C Lin;Suchit Jhunjhunwala;Christopher Benner;Sven Heinz

  • Structural Insights into Histone Demethylation by JMJD2 Family Members

    Zhongzhou Chen;Jianye Zang;Johnathan Whetstine;Xia Hong

  • Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression.

    J Hagman;C Belanger;A Travis;C W Turck

  • Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.

    Daniel Fitzsimmons;W Hodsdon;W Wheat;S M Maira

  • Structural studies of Ets-1/Pax5 complex formation on DNA.

    Colin W Garvie;James Hagman;Cynthia Wolberger

  • Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription.

    Holly Maier;Rachel Ostraat;Hua Gao;Scott Fields

  • An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene

    James Hagman;Rudolf Grosschedl

  • Opposing Functions of the ETS Factor Family Define Shh Spatial Expression in Limb Buds and Underlie Polydactyly

    Laura A. Lettice;Iain Williamson;John H. Wiltshire;Silvia Peluso

  • A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation.

    J. Hagman;A. Travis;R. Grosschedl

  • EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains.

    J. Hagman;M. J. Gutch;Haishan Lin;R. Grosschedl

  • From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment.

    Julita Ramírez;Kara Lukin;James Hagman

  • Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5.

    Hua Gao;Kara Lukin;Julita Ramírez;Scott Fields

  • Early B-Cell Factor, E2A, and Pax-5 Cooperate To Activate the Early B Cell-Specific mb-1 Promoter

    Mikael Sigvardsson;Dawn R. Clark;Dawn R. Clark;Daniel Fitzsimmons;Daniel Fitzsimmons;Michelle Doyle

  • Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

    Catherine A. Musselman;Julita Ramírez;Jennifer K. Sims;Robyn E. Mansfield

  • A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.

    James Hagman;Charles M. Rudin;Deanna Haasch;David Chaplin

  • Transcription factors drive B cell development.

    James Hagman;Kara Lukin

  • Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes.

    Zhixin Zhang;Celia R Espinoza;Zhihong Yu;Robert Stephan

  • Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage

    Melissa A. Thal;Thiago L. Carvalho;Ti He;Hyung-Gyoon Kim

Frequent Co-Authors

Mikael Sigvardsson
Mikael Sigvardsson Lund University
Rudolf Grosschedl
Rudolf Grosschedl Max Planck Society
Ann J. Feeney
Ann J. Feeney Scripps Research Institute
John W. Kappler
John W. Kappler National Jewish Health
Craig T. Jordan
Craig T. Jordan University of Colorado Anschutz Medical Campus
Philippa Marrack
Philippa Marrack National Jewish Health
Tatiana G. Kutateladze
Tatiana G. Kutateladze University of Colorado Denver
Ralph L. Brinster
Ralph L. Brinster University of Pennsylvania
Cornelis Murre
Cornelis Murre University of California, San Diego
Ursula Storb
Ursula Storb University of Chicago

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