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Genetics

D-Index
44
Citations
8418
World Ranking
4259
National Ranking
1837

Overview

Ann J. Feeney is affiliated with the Scripps Research Institute in the United States and works primarily in the fields of immunology and microbiology. Their research spans several subfields, including immunology, molecular biology, radiology, nuclear medicine and imaging, oncology, and parasitology.

The scientist's research focuses on major topics such as T-cell and B-cell immunology, immunotherapy and immune responses, genomics and chromatin dynamics, monoclonal and polyclonal antibodies research, immune cell function and interaction, CAR-T cell therapy research, and parasites and host interactions.

Ann J. Feeney has contributed to multiple publications, with papers appearing in venues such as The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Nature Immunology, and Nature Communications. Some of their recent papers include:

  • Enhancer-instructed epigenetic landscape and chromatin compartmentalization dictate a primary antibody repertoire protective against specific bacterial pathogens, 2023, Nature Immunology
  • An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation, 2023, Nature Communications
  • Enhancers within the Ig V Gene Region Orchestrate Chromatin Topology and Regulate V Gene Rearrangement Frequency to Shape the B Cell Receptor Repertoire Specificities, 2023, The Journal of Immunology
  • An Igh novel enhancer modulates antigen receptor diversity by determining locus conformation, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • VH14-2 mediated nuclear speckles association contributes to radial positioning of the Igh locus and regulates VDJ recombination, 2024, The Journal of Immunology

Frequent collaborators of Ann J. Feeney include Khalid Hussain Bhat, Hammad Farooq, Eden Kleiman, Jie Liang, and Amy Kenter.

Best Publications

  • Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

    Scott R. McKercher;Bruce E. Torbett;Karen L. Anderson;Gregory W. Henkel

  • E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

    Gretchen Bain;Els C.Robanus Maandag;David J. Izon;Derk Amsen

  • Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

    A J Feeney

  • E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells.

    William J Romanow;Anton W Langerak;Peter Goebel;Ingrid L.M Wolvers-Tettero

  • Both E12 and E47 Allow Commitment to the B Cell Lineage

    Gretchen Bain;Els C.Robanus Maandag;Hein P.J.te Riele;Ann J Feeney

  • CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense transcription in pro-B cells

    Stephanie C. Degner;Jiyoti Verma-Gaur;Timothy P. Wong;Claudia Bossen

  • Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

    A J Feeney

  • Cutting Edge: Developmental Stage-Specific Recruitment of Cohesin to CTCF Sites throughout Immunoglobulin Loci during B Lymphocyte Development

    Stephanie C. Degner;Timothy P. Wong;Gytis Jankevicius;Ann J. Feeney

  • Junctional sequences of fetal T cell receptor beta chains have few N regions.

    Ann J. Feeney

  • Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells.

    Peter Goebel;Noel Janney;Joaquín R. Valenzuela;William J. Romanow

  • Transcription factor Pax5 (BSAP) transactivates the RAG-mediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes.

    Zhixin Zhang;Celia R Espinoza;Zhihong Yu;Robert Stephan

  • Repertoire-based selection into the marginal zone compartment during B cell development

    John B. Carey;Chantelle S. Moffatt-Blue;Lisa C. Watson;Amanda L. Gavin

  • Sequence of the spacer in the recombination signal sequence affects V(D)J rearrangement frequency and correlates with nonrandom Vkappa usage in vivo.

    Bertrand Nadel;Alan Tang;Guia Escuro;Geanncarlo Lugo

  • Noncoding transcription within the Igh distal V(H) region at PAIR elements affects the 3D structure of the Igh locus in pro-B cells.

    Jiyoti Verma-Gaur;Ali Torkamani;Lana Schaffer;Stephen R Head

  • A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease.

    A J Feeney;M J Atkinson;M J Cowan;G Escuro

  • Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies.

    Nancy M. Choi;Salvatore Loguercio;Jiyoti Verma-Gaur;Stephanie C. Degner

  • Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location.

    G. S. Williams;A. Martinez;Alina Peraza Montalbano;A. Tang

  • YY1 plays an essential role at all stages of B-cell differentiation

    Eden Kleiman;Haiqun Jia;Salvatore Loguercio;Andrew I. Su

  • Ala-1: A murine alloantigen of activated lymphocytes

    Ann J. Feeney;Ulrich Hämmerling

  • Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.

    Han Yu Shih;Jiyoti Verma-Gaur;Ali Torkamani;Ann J Feeney

Frequent Co-Authors

Cornelis Murre
Cornelis Murre University of California, San Diego
James Hagman
James Hagman University of Colorado Anschutz Medical Campus
Devin Sok
Devin Sok Scripps Research Institute
Ali Torkamani
Ali Torkamani Scripps Health
Donald E. Mosier
Donald E. Mosier Scripps Research Institute
David Nemazee
David Nemazee Scripps Research Institute
Morton J. Cowan
Morton J. Cowan University of California, San Francisco
Andrew I. Su
Andrew I. Su Scripps Research Institute
Maxim N. Artyomov
Maxim N. Artyomov Washington University in St. Louis
Ben Murrell
Ben Murrell Karolinska Institute

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