The scientist’s investigation covers issues in DNA damage, Molecular biology, DNA, DNA repair and Base excision repair. His DNA damage study combines topics from a wide range of disciplines, such as Oxidative stress and Mitochondrion. His research investigates the connection between Molecular biology and topics such as Superoxide dismutase that intersect with problems in Tumor necrosis factor alpha.
He combines subjects such as DNA binding site, Molecular cloning and RNA polymerase, Transcription with his study of DNA. His research in Base excision repair intersects with topics in Mutation, Nucleotide excision repair, DNA glycosylase and Pyrimidine. His Nucleotide excision repair study integrates concerns from other disciplines, such as Photochemistry, Thymine, Guanine and AP site.
His primary areas of investigation include DNA damage, DNA, DNA repair, Molecular biology and Biochemistry. His DNA damage research includes themes of Carcinogenesis, Oxidative stress and Cell biology. His DNA study frequently draws connections between adjacent fields such as Gene.
His DNA repair study frequently draws parallels with other fields, such as Saccharomyces cerevisiae. He has included themes like RNA polymerase, Transcription, Transcription bubble and Polymerase in his Molecular biology study. His Base excision repair research incorporates themes from Mutation, DNA glycosylase and AP site.
Paul W. Doetsch mainly focuses on DNA repair, Cell biology, DNA, DNA damage and DNA replication. His work on Molecular biology expands to the thematically related DNA repair. His biological study spans a wide range of topics, including Base excision repair, Transcription, Saccharomyces cerevisiae and DNA Replication Fork.
While the research belongs to areas of Base excision repair, Paul W. Doetsch spends his time largely on the problem of Nucleotide excision repair, intersecting his research to questions surrounding Oxidative stress. His DNA study is concerned with the field of Genetics as a whole. His work in the fields of DNA damage, such as Genome instability, intersects with other areas such as Context.
Paul W. Doetsch focuses on Cell biology, DNA repair, DNA replication, Homologous recombination and DNA damage. His Cell biology research integrates issues from Cell cycle checkpoint and Biochemistry. His research on DNA repair concerns the broader DNA.
His DNA research is multidisciplinary, incorporating perspectives in Cancer cell, Molecular biology, Cell and Cancer research. The Homologous recombination study combines topics in areas such as Genome integrity, Cancer and Mutant. In general DNA damage, his work in Base excision repair and AP site is often linked to Crosstalk linking many areas of study.
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Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions.
Rossella Marullo;Erica Werner;Natalya Degtyareva;Bryn Moore.
PLOS ONE (2013)
The enzymology of apurinic/apyrimidinic endonucleases
Paul W. Doetsch;Richard P. Cunningham.
Mutation Research (1990)
Base excision repair of oxidative DNA damage activated by XPG protein.
Arne Klungland;Matthias Höss;Daniela Gunz;Angelos Constantinou.
Molecular Cell (1999)
DNA damage-induced reactive oxygen species (ROS) stress response in Saccharomyces cerevisiae.
Lori A. Rowe;Natalya Degtyareva;Paul W. Doetsch.
Free Radical Biology and Medicine (2008)
Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae.
Rebecca L. Swanson;Natalie J. Morey;Paul W. Doetsch;Sue Jinks-Robertson.
Molecular and Cellular Biology (1999)
Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae
Tiffany B. Salmon;Barbara A. Evert;Binwei Song;Paul W. Doetsch.
Nucleic Acids Research (2004)
The current state of eukaryotic DNA base damage and repair.
Nicholas C. Bauer;Anita H. Corbett;Paul W. Doetsch.
Nucleic Acids Research (2015)
Effects of abasic sites and DNA single-strand breaks on prokaryotic RNA polymerases
Wei Zhou;Paul W. Doetsch.
Proceedings of the National Academy of Sciences of the United States of America (1993)
RNA polymerase encounters with DNA damage: transcription-coupled repair or transcriptional mutagenesis?
Tina T Saxowsky;Paul W Doetsch.
Chemical Reviews (2006)
Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae.
Nicole A. Doudican;Binwei Song;Gerald S. Shadel;Paul W. Doetsch.
Molecular and Cellular Biology (2005)
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