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Biology and Biochemistry

D-Index
62
Citations
12817
World Ranking
10865
National Ranking
4710

Overview

Xingming Deng is a researcher affiliated with Emory University in the United States. Their work spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with significant contributions to molecular biology and oncology. Their research topics include DNA repair mechanisms, epigenetics and DNA methylation, RNA modifications related to cancer, and regulation of cell death mechanisms.

Some of the recent notable publications by Xingming Deng include:

  • TGF-β causes Docetaxel resistance in Prostate Cancer via the induction of Bcl-2 by acetylated KLF5 and Protein Stabilization, 2020, Theranostics
  • EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair, 2020, Oncogene
  • Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both, 2022, Oncogene
  • Discovery of Small Molecule Bak Activator for Lung Cancer Therapy, 2021, Theranostics
  • SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks, 2022, Nature Communications

The researcher has frequently collaborated with several colleagues, including David S. Yu, Dongkyoo Park, Elizabeth V. Minten, Priya Kapoor-Vazirani, and Ramona Haji-Seyed-Javadi. These collaborations have resulted in multi-authored publications contributing to various biomedical and cancer research areas.

Xingming Deng regularly publishes in venues such as Oncogene, Journal of Biological Chemistry, Theranostics, Nature Communications, and Cancer Research. These journals reflect their focus on molecular mechanisms underlying cancer and therapeutic resistance, as well as DNA repair and cellular regulation pathways.

Main fields of study for the researcher include biochemistry, genetics, molecular biology, and medicine, with specific subfields in molecular biology, oncology, pulmonary and respiratory medicine, immunology, and cancer research. The central topics of their work revolve around:

  • DNA Repair Mechanisms
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Cell death mechanisms and regulation
  • PARP inhibition in cancer therapy
  • Cancer Mechanisms and Therapy
  • Immunotherapy and Immune Responses

Best Publications

  • Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

    Marina Konopleva;Rooha Contractor;Twee Tsao;Ismael Samudio

  • Phosphorylation of Bcl2 and regulation of apoptosis.

    Peter Ruvolo;X. Deng;W. S. May

  • Novel role for JNK as a stress-activated Bcl2 kinase.

    Xingming Deng;Lei Xiao;Wenhua Lang;Fengqin Gao

  • Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

    Yukinori Minoshima;Toshiyuki Kawashima;Koichi Hirose;Koichi Hirose;Yukio Tonozuka

  • Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases

    Xingming Deng;Peter Ruvolo;Boyd Carr;W. Stratford May

  • Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.

    Meiguo Xin;Xingming Deng

  • Reversion of multidrug resistance by co-encapsulation of doxorubicin and curcumin in chitosan/poly(butyl cyanoacrylate) nanoparticles

    Jinghua Duan;Heidi M. Mansour;Yangde Zhang;Xingming Deng

  • Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions

    Xingming Deng;Fengqin Gao;Tammy Flagg;W. Stratford May

  • Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles

    Jinghua Duan;Yangde Zhang;Shiwei Han;Yuxiang Chen

  • Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A.

    Xingming Deng;Takahiko Ito;Boyd Carr;Marc Mumby

  • A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis.

    Haiqiang Mai;W. Stratford May;Fengqin Gao;Zhaohui Jin

  • Targeting Epstein–Barr virus oncoprotein LMP1-mediated glycolysis sensitizes nasopharyngeal carcinoma to radiation therapy

    L. Xiao;Z-Y Hu;X. Dong;Z. Tan

  • Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS.

    Xingming Deng;Fengqin Gao;W. Stratford May

  • Protein phosphatase 2A enhances the proapoptotic function of Bax through dephosphorylation.

    Meiguo Xin;Xingming Deng

  • Nicotine Induces Multi-site Phosphorylation of Bad in Association with Suppression of Apoptosis

    Zhaohui Jin;Fengqin Gao;Tammy Flagg;Xingming Deng

  • Disruption of STAT3 by niclosamide reverses radioresistance of human lung cancer

    Shuo You;Rui Li;Dongkyoo Park;Maohua Xie

  • Bcl2's Flexible Loop Domain Regulates p53 Binding and Survival

    Xingming Deng;Fengqin Gao;Tammy Flagg;Jessica Anderson

  • SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination.

    Waaqo Daddacha;Allyson E. Koyen;Amanda J. Bastien;Pamela Sara E. Head

  • Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation.

    Zhaohui Jin;Fengqin Gao;Tammy Flagg;Xingming Deng

  • Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer

    Rui Li;Zhongliang Hu;Shi-Yong Sun;Zhuo G. Chen

Frequent Co-Authors

Fadlo R. Khuri
Fadlo R. Khuri American University of Beirut
Taofeek K. Owonikoko
Taofeek K. Owonikoko Emory University
Walter J. Curran
Walter J. Curran Emory University
Suresh S. Ramalingam
Suresh S. Ramalingam Emory University
Shi-Yong Sun
Shi-Yong Sun Emory University
Paul W. Doetsch
Paul W. Doetsch National Institute of Environmental Health Sciences
Dong M. Shin
Dong M. Shin Emory University
Haian Fu
Haian Fu Emory University
Jia Zhou
Jia Zhou The University of Texas Medical Branch at Galveston
Marina Konopleva
Marina Konopleva The University of Texas MD Anderson Cancer Center

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