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Biology and Biochemistry

D-Index
72
Citations
28380
World Ranking
6146
National Ranking
2886

Overview

Haian Fu is affiliated with Emory University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans a range of subfields including molecular biology, pulmonary and respiratory medicine, immunology, oncology, and cancer research.

The primary focus areas of their scientific investigations include computational drug discovery methods, RNA modifications and cancer, bioinformatics and genomic networks, cancer mechanisms and therapy, ubiquitin and proteasome pathways, cancer genomics and diagnostics, and lung cancer treatments and mutations.

Haian Fu's published work appears frequently in several scientific venues, including bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), Cancer Research, Alzheimer's & Dementia, and Nature Communications. The number of publications in these outlets reflects ongoing research activity in both preprint and peer-reviewed journals.

Some of the recent notable papers include:

  • An expanded universe of cancer targets, 2021, Cell
  • YAP1 Expression in SCLC Defines a Distinct Subtype With T-cell-Inflamed Phenotype, 2020, Journal of Thoracic Oncology
  • A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation, 2021, Cancer Discovery
  • Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening, 2020, Journal of Molecular Cell Biology
  • Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion, 2020, Nature Communications

Collaborations have been established with frequent coauthors including Yuhong Du, Andrei A. Ivanov, Ranjita Betarbet, Allan I. Levey, and Xiulei Mo, indicating a networked research environment that supports interdisciplinary and collaborative studies.

Best Publications

  • Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

    Sandeep Robert Datta;Henryk Dudek;Xu Tao;Shane Masters

  • 14-3-3 Proteins: Structure, Function, and Regulation

    Haian Fu;Romesh R. Subramanian;Shane C. Masters

  • Correction: Corrigendum: The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

    Zenggang Li;Andrei A. Ivanov;Rina Su;Valentina Gonzalez-Pecchi

  • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

    Shi Yong Sun;Laura M. Rosenberg;Xuerong Wang;Zhongmei Zhou

  • Crystal structure of the zeta isoform of the 14-3-3 protein.

    Dong Liu;J. Bienkowska;C. Petosa;R. J. Collier

  • Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins.

    Lixin Zhang;Jing Chen;Haian Fu

  • 14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove

    Carlo Petosa;Shane C. Masters;Laurie A. Bankston;Jan Pohl

  • Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism.

    Jing Chen;Katsunori Fujii;Lixin Zhang;Thomas Roberts

  • An improved Tn7-based system for the single-copy insertion of cloned genes into chromosomes of gram-negative bacteria

    Ying Bao;Douglas P. Lies;Haian Fu;Gary P. Roberts

  • Targeting protein-protein interactions as an anticancer strategy

    Andrey Andreyevich Ivanov;Fadlo Khuri;Haian Fu

  • Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display.

    Bingcheng Wang;Hongzhu Yang;Yun Cai Liu;Tomas Jelinek

  • 14-3-3 Proteins Mediate an Essential Anti-apoptotic Signal

    Shane C. Masters;Haian Fu

  • The eukaryotic host factor that activates exoenzyme S of Pseudomonas aeruginosa is a member of the 14-3-3 protein family.

    Haian Fu;J. Coburn;R. J. Collier

  • Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

    Taro Hitosugi;Jun Fan;Tae Wook Chung;Katherine Lythgoe

  • Interaction of the protein kinase Raf-1 with 14-3-3 proteins

    Haian Fu;Kai Xia;D. C. Pallas;Can Cui

  • Association of the Protein Kinases c-Bcr and Bcr-Abl with Proteins of the 14-3-3 Family

    GW Reuther;H Fu;H Fu;LD Cripe;RJ Collier

  • Activation of apoptosis signal-regulating kinase 1 by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3 dissociation

    Erinn H. Goldman;Lei Chen;Haian Fu

  • 14-3-3 Inhibits Bad-Induced Cell Death through Interaction with Serine-136

    Shane C. Masters;Hongzhu Yang;Sandeep Robert Datta;Michael E. Greenberg

  • How Does Arrestin Assemble MAPKs into a Signaling Complex

    Xiufeng Song;Sergio Coffa;Haian Fu;Vsevolod V. Gurevich

  • Interaction of 14-3-3 with a nonphosphorylated protein ligand, exoenzyme S of Pseudomonas aeruginosa.

    Shane C. Masters;Kristin J. Pederson;Lixin Zhang;Joseph T. Barbieri

Frequent Co-Authors

Fadlo R. Khuri
Fadlo R. Khuri American University of Beirut
Shi-Yong Sun
Shi-Yong Sun Emory University
Suresh S. Ramalingam
Suresh S. Ramalingam Emory University
James P. Snyder
James P. Snyder Emory University
Keqiang Ye
Keqiang Ye Shenzhen Institutes of Advanced Technology
Dong M. Shin
Dong M. Shin Emory University
Lixin Zhang
Lixin Zhang East China University of Science and Technology
Michelle R. Arkin
Michelle R. Arkin University of California, San Francisco
Taofeek K. Owonikoko
Taofeek K. Owonikoko Emory University
John R. Horton
John R. Horton The University of Texas MD Anderson Cancer Center

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