World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
52
Citations
14634
World Ranking
13373
National Ranking
3506

Biology and Biochemistry

D-Index
57
Citations
17167
World Ranking
13590
National Ranking
5764

Overview

Michelle R. Arkin is affiliated with the University of California, San Francisco in the United States. Their research spans several areas within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and pharmacology among other subfields.

The primary fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their work delves into multiple subfields with significant contributions in:

  • Molecular Biology
  • Pharmacology
  • Physiology
  • Cell Biology
  • Epidemiology

Research topics covered by Arkin include:

  • Ubiquitin and proteasome pathways
  • 14-3-3 protein interactions
  • Microbial Natural Products and Biosynthesis
  • Alzheimer's disease research and treatments
  • Autophagy in Disease and Therapy
  • Computational Drug Discovery Methods
  • Cholinesterase and Neurodegenerative Diseases

Frequent publication venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell chemical biology
  • Journal of the American Chemical Society
  • Alzheimer s & Dementia
  • Journal of Medicinal Chemistry

Notable recent papers include:

  • High-Throughput Screening: today's biochemical and cell-based approaches, 2020, Drug Discovery Today
  • Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation, 2020, Nature Immunology
  • Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy, 2020, Molecular Neurodegeneration
  • Molecular glues for protein-protein interactions: Progressing toward a new dream, 2024, Cell chemical biology
  • Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH, 2021, ACS Sensors

Collaborations have been established with several frequent co-authors, including:

  • Luc Brunsveld (16 publications)
  • Christian Ottmann (16 publications)
  • Adam R. Renslo (12 publications)
  • Emira J. Visser (10 publications)
  • R. Jeffrey Neitz (10 publications)

Best Publications

  • Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

    Michelle R. Arkin;James A. Wells

  • Long-range photoinduced electron transfer through a DNA helix

    C. J. Murphy;M. R. Arkin;Y. Jenkins;N. D. Ghatlia

  • Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

    Michelle R. Arkin;Yinyan Tang;James A. Wells

  • Pharmacological brake-release of mRNA translation enhances cognitive memory

    Carmela Sidrauski;Diego Acosta-Alvear;Arkady Khoutorsky;Punitha Vedantham

  • Rates of DNA-Mediated Electron Transfer Between Metallointercalators

    M. R. Arkin;E. D. A. Stemp;R. E. Holmlin;J. K. Barton

  • Binding of small molecules to an adaptive protein–protein interface

    Michelle R. Arkin;Mike Randal;Warren L. DeLano;Jennifer Hyde

  • First Observation of the Key Intermediate in the “Light-Switch” Mechanism of [Ru(phen)2dppz]2+

    E. J. C. Olson;D. Hu;A. Hormann;A. M. Jonkman

  • 2.3 A Resolution Cryo-Em Structure of Human P97 and Mechanism of Allosteric Inhibition

    Soojay Banerjee;Alberto Bartesaghi;Alan Merk;Prashant Rao

  • A high throughput drug screen for Entamoeba histolytica identifies a new lead and target

    Anjan Debnath;Derek Parsonage;Rosa M. Andrade;Chen-chen He

  • High-Throughput Screening: today’s biochemical and cell-based approaches

    Vincent Blay;Bhairavi Tolani;Sunita P. Ho;Michelle R. Arkin

  • USP7 small-molecule inhibitors interfere with ubiquitin binding

    Lorna Kategaya;Paola Di Lello;Lionel Rougé;Richard Pastor

  • Discovery of a Potent Small Molecule IL-2 Inhibitor through Fragment Assembly

    Andrew C Braisted;Johan D Oslob;Warren L Delano;Jennifer Hyde

  • OXIDATION OF GUANINE IN DNA BY RU(PHEN)2(DPPZ)3+ USING THE FLASH-QUENCH TECHNIQUE

    E. D. A. Stemp;M. R. Arkin;J. K. Barton

  • Assay Guidance Manual [Internet]

    Sarine Markossian;Abigail Grossman;Kyle Brimacombe;Michelle Arkin

  • Fast photoinduced electron transfer through DNA intercalation

    Catherine J. Murphy;Michelle R. Arkin;Naresh D. Ghatlia;Stefan Bossmann

  • Long-range oxidation of guanine by Ru(III) in duplex DNA

    Michelle R. Arkin;Eric D.A. Stemp;Sabine Coates Pulver;Jacqueline K. Barton

  • Protein-protein interactions and cancer: small molecules going in for the kill.

    Michelle Arkin

  • A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

    Geraldine De Muylder;Kenny K. H. Ang;Steven Chen;Michelle R. Arkin

  • Screening for noise in gene expression identifies drug synergies

    Roy D. Dar;Nina N. Hosmane;Michelle R. Arkin;Robert F. Siliciano;Robert F. Siliciano

  • Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch

    Ciara M Gallagher;Carolina Garri;Erica L Cain;Kenny Kean-Hooi Ang

  • Luminescence Quenching in Supramolecular Systems: A Comparison of DNA- and SDS Micelle-Mediated Photoinduced Electron Transfer between Metal Complexes

    M. R. Arkin;E. D. A. Stemp;C. Turro;N. J. Turro

  • Assay Guidance Manual

    G. Sitta Sittampalam;Nathan P. Coussens;Henrike Nelson;Michelle Arkin

Frequent Co-Authors

James H. McKerrow
James H. McKerrow University of California, San Diego
Jacqueline K. Barton
Jacqueline K. Barton California Institute of Technology
Christopher P. Austin
Christopher P. Austin National Institutes of Health
Haian Fu
Haian Fu Emory University
Lea T. Grinberg
Lea T. Grinberg University of California, San Francisco
Jiri Gut
Jiri Gut University of California, San Francisco
Li Gan
Li Gan Cornell University
James A. Wells
James A. Wells University of California, San Francisco
Katerina Akassoglou
Katerina Akassoglou University of California, San Francisco
Conor R. Caffrey
Conor R. Caffrey University of Montana

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