James A. Wells

Overview

Best Publications

• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  6452
  Citations

• A hot spot of binding energy in a hormone-receptor interface

  Tim Clackson;James A. Wells

  2580
  Citations

• Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

  James A. Wells;Christopher L. McClendon

  2259
  Citations

• K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

  Jonathan M. Ostrem;Ulf Peters;Martin L. Sos;James A. Wells

  2232
  Citations

• Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

  Michelle R. Arkin;James A. Wells

  2100
  Citations

• High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.

  Brian C. Cunningham;James A. Wells

  2094
  Citations

• Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber

  Henner Dennis J;Wells James A;Lowman Henry B;Matthews David J

  2030
  Citations

• Additivity of mutational effects in proteins

  James A. Wells

  1966
  Citations

• Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

  BC Cunningham;M Ultsch;AM De Vos;MG Mulkerrin

  1269
  Citations

• Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

  Michelle R. Arkin;Yinyan Tang;James A. Wells

  1150
  Citations

• Rational design of potent antagonists to the human growth hormone receptor.

  Germaine Fuh;Brian C. Cunningham;Rikiro Fukunaga;Shigekazu Nagata

  890
  Citations

• Dissecting the catalytic triad of a serine protease

  Paul Carter;James A. Wells

  875
  Citations

• Convergent solutions to binding at a protein-protein interface.

  Warren L. DeLano;Mark H. Ultsch;Abraham M. de;Vos

  852
  Citations

• Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites

  James A. Wells;Mark Vasser;David B. Powers

  732
  Citations

• Caspases and their substrates

  Olivier Julien;James A Wells

  725
  Citations

• Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

  Alban Ordureau;Shireen A. Sarraf;David M. Duda;Jin-Mi Heo

  682
  Citations

• Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

  Christian Wiesmann;Germaine Fuh;Hans W. Christinger;Charles Eigenbrot

  666
  Citations

• Comparison of a Structural and a Functional Epitope

  Brian C. Cunningham;James A. Wells

  657
  Citations

• Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males.

  Cindy F. Yang;Michael C. Chiang;Daniel C. Gray;Mahalakshmi Prabhakaran

  646
  Citations

• Hormone phage: an enrichment method for variant proteins with altered binding properties.

  Steven Bass;Ronald Greene;James A. Wells

  646
  Citations