A hot spot of binding energy in a hormone-receptor interface
Tim Clackson;James A. Wells.
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
James A. Wells;Christopher L. McClendon.
Additivity of mutational effects in proteins
James A. Wells.
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.
Brian C. Cunningham;James A. Wells.
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Michelle R. Arkin;James A. Wells.
Nature Reviews Drug Discovery (2004)
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
BC Cunningham;M Ultsch;AM De Vos;MG Mulkerrin.
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Jonathan M. Ostrem;Ulf Peters;Martin L. Sos;James A. Wells.
Enrichment method for variant proteins with altered binding properties
Henner Dennis J;Wells James A;Lowman Henry B;Matthews David J.
Rational design of potent antagonists to the human growth hormone receptor.
Germaine Fuh;Brian C. Cunningham;Rikiro Fukunaga;Shigekazu Nagata.
Dissecting the catalytic triad of a serine protease
Paul Carter;James A. Wells.
If you think any of the details on this page are incorrect, let us know.
We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below: