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James A. Wells

D-Index & Metrics

Biology and Biochemistry

D-Index
129
Citations
75435
World Ranking
415
National Ranking
269

James A. Wells publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where James A. Wells sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 413 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 848 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 949 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 840 scientists 207–216 publications: 733 scientists 217–226 publications: 708 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 417 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 196 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 59 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 642 publications — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

James A. Wells D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where James A. Wells sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 316 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 899 scientists 52–53 D-Index: 1,025 scientists 54–55 D-Index: 1,149 scientists 56–57 D-Index: 1,235 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,162 scientists 62–63 D-Index: 1,130 scientists 64–65 D-Index: 1,031 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 714 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 71 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 129 D-Index — 98th percentile

98% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

James A. Wells is affiliated with the University of California, San Francisco in the United States. Their academic work spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions focused on Molecular Biology, Oncology, Infectious Diseases, Immunology, and Radiology, Nuclear Medicine and Imaging.

The scientist's research topics cover a range of subjects including Monoclonal and Polyclonal Antibodies Research, Peptidase Inhibition and Analysis, CAR-T cell therapy research, SARS-CoV-2 and COVID-19 Research, Immunotherapy and Immune Responses, Click Chemistry and Applications, as well as Protein Degradation and Inhibitors.

James A. Wells has published extensively, with notable recent papers including:

  • Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 (2021, Journal of the American Chemical Society)
  • Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 (2020, Proceedings of the National Academy of Sciences)
  • Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins (2022, Nature Biotechnology)
  • SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay (2021, Science Advances)
  • Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection (2021, Nature Biotechnology)

The scientist frequently collaborates with colleagues such as Kevin K. Leung, Irene Lui, James R. Byrnes, Shion A. Lim, and Lisa L. Kirkemo. Publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Journal of the American Chemical Society
  • Nature Chemical Biology
  • ACS Chemical Biology

Best Publications

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • A hot spot of binding energy in a hormone-receptor interface

    Tim Clackson;James A. Wells

  • Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

    James A. Wells;Christopher L. McClendon

  • K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

    Jonathan M. Ostrem;Ulf Peters;Martin L. Sos;James A. Wells

  • Small-molecule inhibitors of protein–protein interactions: progressing towards the dream

    Michelle R. Arkin;James A. Wells

  • High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.

    Brian C. Cunningham;James A. Wells

  • Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber

    Henner Dennis J;Wells James A;Lowman Henry B;Matthews David J

  • Additivity of mutational effects in proteins

    James A. Wells

  • Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule

    BC Cunningham;M Ultsch;AM De Vos;MG Mulkerrin

  • Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

    Michelle R. Arkin;Yinyan Tang;James A. Wells

  • Rational design of potent antagonists to the human growth hormone receptor.

    Germaine Fuh;Brian C. Cunningham;Rikiro Fukunaga;Shigekazu Nagata

  • Dissecting the catalytic triad of a serine protease

    Paul Carter;James A. Wells

  • Convergent solutions to binding at a protein-protein interface.

    Warren L. DeLano;Mark H. Ultsch;Abraham M. de;Vos

  • Cassette mutagenesis: an efficient method for generation of multiple mutations at defined sites

    James A. Wells;Mark Vasser;David B. Powers

  • Caspases and their substrates

    Olivier Julien;James A Wells

  • Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

    Alban Ordureau;Shireen A. Sarraf;David M. Duda;Jin-Mi Heo

  • Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor

    Christian Wiesmann;Germaine Fuh;Hans W. Christinger;Charles Eigenbrot

  • Comparison of a Structural and a Functional Epitope

    Brian C. Cunningham;James A. Wells

  • Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males.

    Cindy F. Yang;Michael C. Chiang;Daniel C. Gray;Mahalakshmi Prabhakaran

  • Hormone phage: an enrichment method for variant proteins with altered binding properties.

    Steven Bass;Ronald Greene;James A. Wells

Frequent Co-Authors

Henry B. Lowman
Henry B. Lowman Genentech
Germaine Fuh
Germaine Fuh Genentech
Leonard G. Presta
Leonard G. Presta Genentech
Jonathan S. Weissman
Jonathan S. Weissman MIT
Mark Ultsch
Mark Ultsch Genentech
Sachdev S. Sidhu
Sachdev S. Sidhu University of Waterloo
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco
Anthony A. Kossiakoff
Anthony A. Kossiakoff University of Chicago
Paul J. Carter
Paul J. Carter Genentech
Michelle R. Arkin
Michelle R. Arkin University of California, San Francisco

External Links

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Best Scientists Citing James A. Wells

Sachdev S. Sidhu

Sachdev S. Sidhu

University of Waterloo

Publications: 145

David R. Liu

David R. Liu

Broad Institute

Publications: 75

Anthony A. Kossiakoff

Anthony A. Kossiakoff

University of Chicago

Publications: 70

Manfred T. Reetz

Manfred T. Reetz

Max Planck Society

Publications: 67

John J. Kopchick

John J. Kopchick

Ohio University

Publications: 62

Paul A. Kelly

Paul A. Kelly

Queen Mary University of London

Publications: 56

Ruth Nussinov

Ruth Nussinov

National Institutes of Health

Publications: 55

Henry B. Lowman

Henry B. Lowman

Genentech

Publications: 54

Charles S. Craik

Charles S. Craik

University of California, San Francisco

Publications: 53

Stuart J. Frank

Stuart J. Frank

University of Alabama at Birmingham

Publications: 52

Vincent Goffin

Vincent Goffin

Université Paris Cité

Publications: 50

K. Christopher Garcia

K. Christopher Garcia

Stanford University

Publications: 49

Napoleone Ferrara

Napoleone Ferrara

University of California, San Diego

Publications: 48

Lorenzo Galluzzi

Lorenzo Galluzzi

Cornell University

Publications: 48

Leonard G. Presta

Leonard G. Presta

Genentech

Publications: 45

Michael J. Waters

Michael J. Waters

University of Queensland

Publications: 45

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