A hot spot of binding energy in a hormone-receptor interface
Tim Clackson;James A. Wells.
Science (1995)
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
James A. Wells;Christopher L. McClendon.
Nature (2007)
Additivity of mutational effects in proteins
James A. Wells.
Biochemistry (1990)
High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis.
Brian C. Cunningham;James A. Wells.
Science (1989)
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Michelle R. Arkin;James A. Wells.
Nature Reviews Drug Discovery (2004)
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule
BC Cunningham;M Ultsch;AM De Vos;MG Mulkerrin.
Science (1991)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Jonathan M. Ostrem;Ulf Peters;Martin L. Sos;James A. Wells.
Nature (2013)
Enrichment method for variant proteins with altered binding properties
Henner Dennis J;Wells James A;Lowman Henry B;Matthews David J.
(1991)
Rational design of potent antagonists to the human growth hormone receptor.
Germaine Fuh;Brian C. Cunningham;Rikiro Fukunaga;Shigekazu Nagata.
Science (1992)
Dissecting the catalytic triad of a serine protease
Paul Carter;James A. Wells.
Nature (1988)
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Genentech
Genentech
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University of Toronto
University of California, San Francisco
University of Chicago
University of California, San Francisco
Genentech
University of Castilla-La Mancha
Dalian University of Technology
Brown University
Institut de Recherche pour le Développement
MRC Laboratory of Molecular Biology
University of Sydney
Peking University
Swansea University
University of Clermont Auvergne
University of Melbourne
University of Arizona
National and Kapodistrian University of Athens
University of Alabama
University College London
University of Jyväskylä
University of Amsterdam