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132
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67164
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2309
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Overview

Juan C. Troncoso is affiliated with Johns Hopkins University School of Medicine in the United States. Their research expertise spans several fields within medicine and the biological sciences.

The main fields of study for their work include Medicine and Biochemistry, Genetics and Molecular Biology. More specifically, their subfields cover Neurology, Physiology, Molecular Biology, Cellular and Molecular Neuroscience, and Radiology, Nuclear Medicine and Imaging.

The primary research topics addressed by Juan C. Troncoso focus on neurological diseases and neurodegeneration, including:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Dementia and Cognitive Impairment Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Advanced Neuroimaging Techniques and Applications
  • Neurological diseases and metabolism
  • Amyotrophic Lateral Sclerosis Research

Juan C. Troncoso has published frequently in several notable venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia
  • Journal of Neuropathology & Experimental Neurology
  • Acta Neuropathologica
  • Neuron

The scientist's frequent coauthors include Javier Redding-Ochoa, Olga Pletniková, Ted M. Dawson, Dennis W. Dickson, and Liana S. Rosenthal. These collaborations represent sustained research partnerships across multiple studies.

Some recent papers by Juan C. Troncoso include:

  • Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation, published in 2020 in Nature Medicine
  • Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture, 2021, Nature Genetics
  • Discovery of several thousand highly diverse circular DNA viruses, 2020, eLife
  • STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy, 2022, Proceedings of the National Academy of Sciences
  • Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease, 2021, Acta Neuropathologica Communications

Best Publications

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Primary age-related tauopathy (PART): a common pathology associated with human aging

    John F. Crary;John Q. Trojanowski;Julie A. Schneider;Jose F. Abisambra

  • Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

    M.J West;P.D Coleman;D.G Flood;J.C Troncoso

  • Interference by Huntingtin and Atrophin-1 with CBP-Mediated Transcription Leading to Cellular Toxicity

    Frederick C. Nucifora;Masayuki Sasaki;Matthew F. Peters;Hui Huang

  • Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

    Roy G. Cutler;Jeremiah Kelly;Kristin Storie;Ward A. Pedersen

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • C9orf72 nucleotide repeat structures initiate molecular cascades of disease

    Aaron R. Haeusler;Christopher J. Donnelly;Goran Periz;Eric A.J. Simko

  • Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

    Erik C.B. Johnson;Eric B. Dammer;Duc M. Duong;Lingyan Ping

  • Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations

    Anne M. Cataldo;Corrinne M. Peterhoff;Juan C. Troncoso;Teresa Gomez-Isla

  • Common genetic variants influence human subcortical brain structures.

    Derrek P. Hibar;Jason L. Stein;Jason L. Stein;Miguel E. Renteria;Alejandro Arias-Vasquez

  • S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function

    Kenny K. K. Chung;Bobby Thomas;Xiaojie Li;Olga Pletnikova

  • Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

    J. Raphael Gibbs;J. Raphael Gibbs;Marcel P. van der Brug;Marcel P. van der Brug;Dena G. Hernandez;Dena G. Hernandez;Bryan J. Traynor

  • RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

    Tao Zu;Yuanjing Liu;Monica Bañez-Coronel;Tammy Reid

  • The transcriptional landscape of age in human peripheral blood

    Marjolein J. Peters;Roby Joehanes;Luke C. Pilling;Claudia Schurmann;Claudia Schurmann

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease

    Chun I. Sze;Juan C. Troncoso;Claudia Kawas;Peter Mouton

  • Gene expression changes in the course of normal brain aging are sexually dimorphic.

    Nicole C. Berchtold;David H. Cribbs;Paul D. Coleman;Joseph Rogers

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.

    Simone Engelender;Zachary Kaminsky;Xin Guo;Alan H. Sharp

Frequent Co-Authors

Ted M. Dawson
Ted M. Dawson Johns Hopkins University School of Medicine
Donald L. Price
Donald L. Price Johns Hopkins University
Sonja W. Scholz
Sonja W. Scholz National Institutes of Health
Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
Susan M. Resnick
Susan M. Resnick National Institutes of Health
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
James J. Lah
James J. Lah Emory University
John Hardy
John Hardy University College London
Allan I. Levey
Allan I. Levey Emory University

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