H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 55 Citations 12,912 110 World Ranking 7346 National Ranking 3337

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Alzheimer's disease

James J. Lah spends much of his time researching Alzheimer's disease, Disease, Genetics, Neuroscience and Amyloid precursor protein. His Alzheimer's disease study incorporates themes from Biomarker and Apolipoprotein E. His studies deal with areas such as Transcriptome, Cognition, Microglia, Medical genetics and Pathophysiology as well as Disease.

His study on Genome-wide association study, Locus, Genetic variants and Genetic variation is often connected to Pancreatic disease as part of broader study in Genetics. James J. Lah has included themes like Transmembrane protein, Molecular biology, Alanine and Intracellular, Cell biology in his Amyloid precursor protein study. In his study, which falls under the umbrella issue of Internal medicine, Odds ratio is strongly linked to Oncology.

His most cited work include:

  • Variant of TREM2 associated with the risk of Alzheimer's disease (1465 citations)
  • Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease (1385 citations)
  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis (450 citations)

What are the main themes of his work throughout his whole career to date?

James J. Lah mostly deals with Disease, Alzheimer's disease, Neuroscience, Cell biology and Dementia. His Disease study combines topics in areas such as Genetics, Proteome, Computational biology and Immunology. His Alzheimer's disease study combines topics from a wide range of disciplines, such as Biomarker, Apolipoprotein E and SORL1.

His research in Cell biology intersects with topics in Neuroinflammation, Neurodegeneration, Microglia and Amyloid precursor protein. James J. Lah combines subjects such as Molecular biology and Genetically modified mouse with his study of Amyloid precursor protein. The concepts of his Dementia study are interwoven with issues in Cognition, Oncology and Gerontology.

He most often published in these fields:

  • Disease (26.98%)
  • Alzheimer's disease (20.50%)
  • Neuroscience (17.63%)

What were the highlights of his more recent work (between 2018-2021)?

  • Disease (26.98%)
  • Dementia (15.47%)
  • Human brain (10.43%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Disease, Dementia, Human brain, Neuroscience and Proteome. His Disease research is included under the broader classification of Pathology. The Dementia study combines topics in areas such as Biomarker, Cognition, Oncology and Gerontology.

The various areas that James J. Lah examines in his Human brain study include Genetics and Depression. James J. Lah has researched Neuroscience in several fields, including Cerebral atherosclerosis and Amyloid. His Proteome study integrates concerns from other disciplines, such as Multiplex, Proteomics, Quantitative trait locus, Tandem mass tag and Computational biology.

Between 2018 and 2021, his most popular works were:

  • Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation (113 citations)
  • Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age (52 citations)
  • Tau PET in autosomal dominant Alzheimer's disease: Relationship with cognition, dementia and other biomarkers (43 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Enzyme

James J. Lah focuses on Dementia, Proteomics, Proteome, Disease and Computational biology. James J. Lah interconnects Nursing, Cognition and Neurodegeneration in the investigation of issues within Dementia. His research investigates the connection with Neurodegeneration and areas like Loss function which intersect with concerns in Cell biology.

His work deals with themes such as Quantitative trait locus, Multiplex and Human brain, which intersect with Proteome. His Disease study is concerned with Pathology in general. His work in Cognitive test addresses subjects such as Oncology, which are connected to disciplines such as Internal medicine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

Variant of TREM2 associated with the risk of Alzheimer's disease

Thorlakur Jonsson;Hreinn Stefansson;Stacy Steinberg;Ingileif Jonsdottir.
The New England Journal of Medicine (2013)

1607 Citations

Common variants at MS4A4/MS4A6E , CD2AP , CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang.
Nature Genetics (2011)

1580 Citations

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez.
Nature Communications (2016)

523 Citations

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

Vivianna M. Van Deerlin;Patrick M A Sleiman;Maria Martinez-Lage;Maria Martinez-Lage;Alice Chen-Plotkin.
Nature Genetics (2010)

435 Citations

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez.
Nature Genetics (2017)

382 Citations

Loss of apolipoprotein E receptor LR11 in Alzheimer disease.

Clemens R. Scherzer;Katrin Offe;Marla Gearing;Howard D. Rees.
JAMA Neurology (2004)

338 Citations

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments.

Katrin Offe;Sara E. Dodson;James T. Shoemaker;Jason J. Fritz.
The Journal of Neuroscience (2006)

306 Citations

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

David C. Whitcomb;Jessica LaRusch;Alyssa M. Krasinskas;Lambertus Klei.
Nature Genetics (2012)

297 Citations

Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection

Lujian Liao;Dongmei Cheng;Jian Wang;Duc M. Duong.
Journal of Biological Chemistry (2004)

294 Citations

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

Stacy Steinberg;Hreinn Stefansson;Thorlakur Jonsson;Hrefna Johannsdottir.
Nature Genetics (2015)

260 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

If you think any of the details on this page are incorrect, let us know.

Contact us

Top Scientists Citing James J. Lah

Philip L. De Jager

Philip L. De Jager

Columbia University

Publications: 148

David A. Bennett

David A. Bennett

Rush University Medical Center

Publications: 143

Lan Tan

Lan Tan

Qingdao University

Publications: 133

Henrik Zetterberg

Henrik Zetterberg

University of Gothenburg

Publications: 123

Jin-Tai Yu

Jin-Tai Yu

Fudan University

Publications: 118

John Hardy

John Hardy

University College London

Publications: 118

Kaj Blennow

Kaj Blennow

University of Gothenburg

Publications: 107

Alison Goate

Alison Goate

Icahn School of Medicine at Mount Sinai

Publications: 102

Richard Mayeux

Richard Mayeux

Columbia University

Publications: 97

Christian Haass

Christian Haass

Ludwig Maximilian University of Munich

Publications: 96

Lindsay A. Farrer

Lindsay A. Farrer

Boston University

Publications: 93

Margaret A. Pericak-Vance

Margaret A. Pericak-Vance

University of Miami

Publications: 90

John Q. Trojanowski

John Q. Trojanowski

University of Pennsylvania

Publications: 90

Dennis W. Dickson

Dennis W. Dickson

Mayo Clinic

Publications: 89

Peter St George-Hyslop

Peter St George-Hyslop

University of Cambridge

Publications: 83

Something went wrong. Please try again later.