Nicholas T. Seyfried

Overview

Best Publications

• Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation.

  Ping Xu;Duc M. Duong;Nicholas T. Seyfried;Dongmei Cheng

  1359
  Citations

• Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

  Erik C.B. Johnson;Eric B. Dammer;Duc M. Duong;Lingyan Ping

  982
  Citations

• TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD

  Ching Chieh Chou;Yi Zhang;Yi Zhang;Mfon E. Umoh;Spencer W. Vaughan

  591
  Citations

• The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.

  Minghui Wang;Noam D. Beckmann;Panos Roussos;Erming Wang

  553
  Citations

• Continuous release of endostatin from microencapsulated engineered cells for tumor therapy.

  Tatsuhiro Joki;Tatsuhiro Joki;Tatsuhiro Joki;Marcelle Machluf;Anthony Atala;Jianhong Zhu;Jianhong Zhu

  478
  Citations

• Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease

  Zhentao Zhang;Mingke Song;Xia Liu;Seong Su Kang

  443
  Citations

• A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

  Nicholas T. Seyfried;Eric B. Dammer;Vivek Swarup;Divya Nandakumar

  430
  Citations

• Evidence for brain glucose dysregulation in Alzheimer's disease

  Yang An;Vijay R. Varma;Sudhir Varma;Ramon Casanova

  411
  Citations

• Expression of Cyclooxygenase 2 (COX-2) in Human Glioma and in Vitro Inhibition by a Specific COX-2 Inhibitor, NS-398

  Tatsuhiro Joki;Oliver Heese;Demetrios C. Nikas;Lorenzo Bello

  368
  Citations

• Glutamate Dehydrogenase 1 Signals through Antioxidant Glutathione Peroxidase 1 to Regulate Redox Homeostasis and Tumor Growth

  Lingtao Jin;Dan Li;Gina N. Alesi;Jun Fan

  340
  Citations

• Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains.

  Tamta Arakhamia;Christina E. Lee;Yari Carlomagno;Duc M. Duong

  332
  Citations

• Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

  Srikant Rangaraju;Eric B. Dammer;Syed Ali Raza;Priyadharshini Rathakrishnan

  327
  Citations

• U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.

  Bing Bai;Chadwick M. Hales;Ping Chung Chen;Yair Gozal

  313
  Citations

• Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

  Zhentao Zhang;Zhentao Zhang;Mingke Song;Xia Liu;Seong Su Kang

  268
  Citations

• Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis

  Aliza P. Wingo;Aliza P. Wingo;Yue Liu;Ekaterina S. Gerasimov;Jake Gockley

  252
  Citations

• Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease

  Lenora Higginbotham;Lingyan Ping;Eric B. Dammer;Duc M. Duong

  251
  Citations

• Polyubiquitin Linkage Profiles in Three Models of Proteolytic Stress Suggest the Etiology of Alzheimer Disease

  Eric B. Dammer;Chan Hyun Na;Ping Xu;Nicholas T. Seyfried

  200
  Citations

• Global quantitative analysis of the human brain proteome in Alzheimer’s and Parkinson’s Disease

  Lingyan Ping;Duc M. Duong;Luming Yin;Marla Gearing

  198
  Citations

• Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

  Erik C. B. Johnson;Eric B. Dammer;Duc M. Duong;Luming Yin

  190
  Citations

• TDP-43 PATHOLOGY DISRUPTS NUCLEAR PORE COMPLEXES AND NUCLEOCYTOPLASMIC TRANSPORT IN ALS/FTD

  Ching-Chieh Chou;Yi Zhang;Mfon Umoh;Nicholas T. Seyfried

  0
  Citations