Francis M. Sirotnak

Overview

Best Publications

• Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase

  Francis M. Sirotnak;Maureen F. Zakowski;Vincent A. Miller;Howard I. Scher

  979
  Citations

• Carrier-mediated membrane transport of folates in mammalian cells

  F. M. Sirotnak;Berend Tolner

  375
  Citations

• Relative Frequency and Kinetic Properties of Transport-defective Phenotypes among Methotrexate-resistant L1210 Clonal Cell Lines Derived in Vivo

  F. M. Sirotnak;D. M. Moccio;L. E. Kelleher;L. J. Goutas

  260
  Citations

• New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

  F. M. Sirotnak;J. I. DeGraw;D. M. Moccio;L. L. Samuels

  207
  Citations

• Expression and Differential Polarization of the Reduced-folate Transporter-1 and the Folate Receptor α in Mammalian Retinal Pigment Epithelium *

  Christy D. Chancy;Ramesh Kekuda;Wei Huang;Puttur D Prasad

  205
  Citations

• New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models

  F. M. Sirotnak;J. I. DeGraw;F. A. Schmid;L. J. Goutas

  202
  Citations

• Correlates of folate analog transport, pharmacokinetics and selective antitumor action

  Francis M. Sirotnak

  192
  Citations

• On the Nature of a Transport Alteration Determining Resistance to Amethopterin in the L1210 Leukemia

  Francis M. Sirotnak;Soji Kurita;Dorris J. Hutchison

  187
  Citations

• Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.

  J R Piper;G S McCaleb;J A Montgomery;R L Kisliuk

  163
  Citations

• Adaptive regulation of intestinal folate uptake: effect of dietary folate deficiency.

  Hamid M. Said;Nabendu Chatterjee;Riaz Ul Haq;Veedamali S. Subramanian

  160
  Citations

• Studies with CWR22 Xenografts in Nude Mice Suggest That ZD1839 May Have a Role in the Treatment of Both Androgen-dependent and Androgen-independent Human Prostate Cancer

  Francis M Sirotnak;Yohung She;Fei Lee;Jing Chen

  145
  Citations

• Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.

  Monica Motwani;Christoph Jung;Francis M. Sirotnak;Yuhong She

  144
  Citations

• Studies with ZD1839 in preclinical models

  Francis M Sirotnak

  135
  Citations

• RFC-1 Gene Expression Regulates Folate Absorption in Mouse Small Intestine

  Judy H. Chiao;Krishnendu Roy;Berend Tolner;Ching-Hsiung Yang

  133
  Citations

• Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics

  Mona D. Lee;Yuhong She;Michael J. Soskis;Christopher P. Borella

  129
  Citations

• Differential Synthesis of Methotrexate Polyglutamates in Normal Proliferative and Neoplastic Mouse Tissues in Vivo

  Richard G. Poser;Francis M. Sirotnak;Paul L. Chello

  121
  Citations

• Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.

  Lawrence L. Samuels;Donna M. Moccio;Francis M. Sirotnak

  119
  Citations

• Stereospecificity at carbon 6 of formyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

  Francis M. Sirotnak;Paul L. Chello;Donna M. Moccio;Roy L. Kisliuk

  117
  Citations

• Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models.

  Francis M. Sirotnak;Donna M. Moccio;Diane M. Dorick

  113
  Citations

• Flavopiridol Enhances the Effect of Docetaxel in Vitro and in Vivo in Human Gastric Cancer Cells1

  Monica Motwani;Carina Rizzo;Francis Sirotnak;Yuhong She

  112
  Citations